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Lactonase
Lactonase (EC 3.1.1.81, acyl-homoserine lactonase; systematic name ''N''-acyl-L-homoserine-lactone lactonohydrolase) is a metalloenzyme, produced by certain species of bacteria, which targets and inactivates acylated homoserine lactones (AHLs). It catalyzes the reaction : an ''N''-acyl-L-homoserine lactone + H2O \rightleftharpoons an ''N''-acyl-L-homoserine Many species of α-, β-, and γ-proteobacteria produce acylated homoserine lactones, small hormone-like molecules commonly used as communication signals between bacterial cells in a population to regulate certain gene expression and phenotypic behaviours. This type of gene regulation is known as quorum sensing. Other names for these types of enzymes are Quorum-quenching ''N''-acyl-homoserine lactonase, acyl homoserine degrading enzyme, acyl-homoserine lactone acylase, AHL lactonase, AHL-degrading enzyme, AHL-inactivating enzyme, AHLase, AhlD, AhlK, AiiA, AiiA lactonase, AiiA-like protein, AiiB, AiiC, AttM, delactonase, lac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lactonase Dinuclear Zinc
Lactonase (EC 3.1.1.81, acyl-homoserine lactonase; systematic name ''N''-acyl-L-homoserine-lactone lactonohydrolase) is a metalloenzyme, produced by certain species of bacteria, which targets and inactivates acylated homoserine lactones (AHLs). It catalyzes the reaction : an ''N''-acyl-L-homoserine lactone + H2O \rightleftharpoons an ''N''-acyl-L-homoserine Many species of α-, β-, and γ-proteobacteria produce acylated homoserine lactones, small hormone-like molecules commonly used as communication signals between bacterial cells in a population to regulate certain gene expression and phenotypic behaviours. This type of gene regulation is known as quorum sensing. Other names for these types of enzymes are Quorum-quenching ''N''-acyl-homoserine lactonase, acyl homoserine degrading enzyme, acyl-homoserine lactone acylase, AHL lactonase, AHL-degrading enzyme, AHL-inactivating enzyme, AHLase, AhlD, AhlK, AiiA, AiiA lactonase, AiiA-like protein, AiiB, AiiC, AttM, delactonase, lac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lactonase Active Site
Lactonase (EC 3.1.1.81, acyl-homoserine lactonase; systematic name ''N''-acyl-L-homoserine-lactone lactonohydrolase) is a metalloenzyme, produced by certain species of bacteria, which targets and inactivates acylated homoserine lactones (AHLs). It catalyzes the reaction : an ''N''-acyl-L-homoserine lactone + H2O \rightleftharpoons an ''N''-acyl-L-homoserine Many species of α-, β-, and γ-proteobacteria produce acylated homoserine lactones, small hormone-like molecules commonly used as communication signals between bacterial cells in a population to regulate certain gene expression and phenotypic behaviours. This type of gene regulation is known as quorum sensing. Other names for these types of enzymes are Quorum-quenching ''N''-acyl-homoserine lactonase, acyl homoserine degrading enzyme, acyl-homoserine lactone acylase, AHL lactonase, AHL-degrading enzyme, AHL-inactivating enzyme, AHLase, AhlD, AhlK, AiiA, AiiA lactonase, AiiA-like protein, AiiB, AiiC, AttM, delactonase, lac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lactonase Mechanism
Lactonase (EC 3.1.1.81, acyl-homoserine lactonase; systematic name ''N''-acyl-L-homoserine-lactone lactonohydrolase) is a metalloenzyme, produced by certain species of bacteria, which targets and inactivates acylated homoserine lactones (AHLs). It catalyzes the reaction : an ''N''-acyl-L-homoserine lactone + H2O \rightleftharpoons an ''N''-acyl-L-homoserine Many species of α-, β-, and γ-proteobacteria produce acylated homoserine lactones, small hormone-like molecules commonly used as communication signals between bacterial cells in a population to regulate certain gene expression and phenotypic behaviours. This type of gene regulation is known as quorum sensing. Other names for these types of enzymes are Quorum-quenching ''N''-acyl-homoserine lactonase, acyl homoserine degrading enzyme, acyl-homoserine lactone acylase, AHL lactonase, AHL-degrading enzyme, AHL-inactivating enzyme, AHLase, AhlD, AhlK, AiiA, AiiA lactonase, AiiA-like protein, AiiB, AiiC, AttM, delactonase, lac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gluconolactonase
The enzyme gluconolactonase (EC 3.1.1.17) catalyzes the reaction :D-glucono-1,5-lactone + H2O \rightleftharpoons D-gluconate This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is D-glucono-1,5-lactone lactonohydrolase. Other names in common use include lactonase, aldonolactonase, glucono-δ-lactonase, and gulonolactonase. This enzyme participates in three metabolic pathways: pentose phosphate pathway, ascorbate and aldarate metabolism, and caprolactam degradation Caprolactam (CPL) is an organic compound with the formula (CH2)5C(O)NH. This colourless solid is a lactam (a cyclic amide) of caproic acid. Global demand for this compound is approximately five million tons per year, and the vast majority is used .... References * * * EC 3.1.1 Enzymes of unknown structure {{3.1-enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paraoxonase
Paraoxonases are a family of mammalian enzymes with aryldialkylphosphatase activity. There are three paraoxonase isozymes, which were originally discovered for their involvement in the hydrolysis of organophosphates. Research has indicated the enzymatic activity of paraoxonases is more diversified than its activity as an organophosphatase. Esterase and lactonase activity has also been observed from these enzymes and though the physiologically relevant substrates for these enzymes are unknown, it is likely that lactones are the main substrate (although there is a relatively high level of variation in substrate specificity among these enzymes). Most of the studies on the paraoxonase family have specifically looked at the paraoxonase 1 type, leaving much to be learned about the remaining two. The study of this enzyme family has many potential consequences in preventative medicine and toxicology as well as in certain societal contexts. The genes that encode for these enzymes have a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-oxoadipate Enol-lactonase
In enzymology, a 3-oxoadipate enol-lactonase () is an enzyme that catalyzes the chemical reaction :3-oxoadipate enol-lactone + H2O \rightleftharpoons 3-oxoadipate Thus, the two substrates of this enzyme are 3-oxoadipate enol-lactone and H2O, whereas its product is 3-oxoadipate. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase. Other names in common use include carboxymethylbutenolide lactonase, beta-ketoadipic enol-lactone hydrolase, 3-ketoadipate enol-lactonase, 3-oxoadipic enol-lactone hydrolase, and beta-ketoadipate enol-lactone hydrolase. This enzyme participates in benzoate degradation via hydroxylation Benzoate degradation via hydroxylation is an enzyme-catalyzed, bacterial chemical reaction. Benzoate is degraded aerobically and anaerobically. Aerobic degradation forms catechol. Anaerobic degradation forms cyclohex-1,5- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1,4-lactonase
In enzymology, a 1,4-lactonase () is an enzyme that catalyzes the generic chemical reaction: :a 1,4-lactone + HO \rightleftharpoons a 4-hydroxyacid Thus, the two substrates of this enzyme are 1,4-lactone and HO, whereas its product is 4-hydroxyacid. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1,4-lactone . This enzyme is also called gamma-lactonase. This enzyme participates in galactose metabolism and ascorbate and aldarate metabolism. It employs one cofactor, calcium. Structural studies As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes , , and . Applications In a study by Chen et al. a 1,4-lactonase was expressed in E. coli and used as a highly efficient biocatalyst for asymmetric synthesis Enantioselective synthesis, also called asymmetric synthesis, is a form of chemical synthesis. It is defined by IUPAC as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
L-rhamnono-1,4-lactonase
The enzyme L-rhamnono-1,4-lactonase (EC 3.1.1.65) catalyzes the reaction :L-rhamnono-1,4-lactone + H2O \rightleftharpoons Lrhamnonate This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is L-rhamnono-1,4-lactone lactonohydrolase. Other names in common use include Lrhamno-γ-lactonase, L-rhamnono-γ-lactonase, and L-rhamnonate dehydratase. This enzyme participates in fructose and mannose metabolism Mannose is a sugar monomer of the aldohexose series of carbohydrates. It is a C-2 epimer of glucose. Mannose is important in human metabolism, especially in the glycosylation of certain proteins. Several congenital disorders of glycosylation .... References * EC 3.1.1 Enzymes of unknown structure {{3.1-enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actinomycin Lactonase
The enzyme actinomycin lactonase (EC 3.1.1.39) catalyzes the reaction :actinomycin + H2O \rightleftharpoons actinomycinic monolactone This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... is actinomycin lactonohydrolase. References * EC 3.1.1 Enzymes of unknown structure {{3.1-enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deoxylimonate A-ring-lactonase
The enzyme deoxylimonate A-ring-lactonase (EC 3.1.1.46) catalyzes the reaction :deoxylimonate + H2O \rightleftharpoons deoxylimononic acid D-ring-lactone The reaction opens the A-ring-lactone of the triterpenoid deoxylimonic acid, leaving the D-ring-lactone intact. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... is deoxylimonate A-ring-lactonohydrolase. References * {{3.1-enzyme-stub EC 3.1.1 Enzymes of unknown structure ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2-pyrone-4,6-dicarboxylate Lactonase
The enzyme 2-pyrone-4,6-dicarboxylate lactonase (EC 3.1.1.57, LigI) catalyzes the reversible hydrolytic reaction :2-oxo-2''H''-pyran-4,6-dicarboxylate + H2O = (1''E'')-4-oxobut-1-ene-1,2,4-tricarboxylate This enzyme belongs to the Amidohydrolase superfamily of enzymes and is a member of Cluster of Orthologous Groups (COG) 3618. The systematic name of this enzyme is 2-oxo-2''H''-pyran-4,6-dicarboxylate lactonohydrolase. This enzyme is found to play an important role in the metabolism of lignin-derived aromatic compounds in both the syringate degradation pathway and the protocatechuate 4,5-cleavage pathway. LigI from ''Sphingomonas'' is of particular interest as it has been shown to be the first member of the amidohydrolase Amidohydrolases (or amidases) are a type of hydrolase that acts upon amide bonds. They are categorized under EC number EC 3.5.1 and 3.5.2. Examples include: * Beta-lactamase * Histone deacetylase * Urease Ureases (), functionally, belong to t ... superfa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lactone
Lactones are cyclic carboxylic esters, containing a 1-oxacycloalkan-2-one structure (), or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. Lactones are formed by intramolecular esterification of the corresponding hydroxycarboxylic acids, which takes place spontaneously when the ring that is formed is five- or six-membered. Lactones with three- or four-membered rings (α-lactones and β-lactones) are very reactive, making their isolation difficult. Special methods are normally required for the laboratory synthesis of small-ring lactones as well as those that contain rings larger than six-membered. Nomenclature Lactones are usually named according to the precursor acid molecule (''aceto'' = 2 carbon atoms, ''propio'' = 3, ''butyro'' = 4, ''valero'' = 5, ''capro'' = 6, etc.), with a ''-lactone'' suffix and a Greek letter prefix that specifies the number of carbon atoms in the heterocycle — that is, the distance between the relevant -OH ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
