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Kaliseptine
Kaliseptine (AsKS) is a neurotoxin which can be found in the snakelocks anemone ''Anemonia viridis''. It belongs to a class of sea anemone neurotoxins that inhibits voltage-gated potassium channels. Etymology “Kali” is derived from the Latin word alium which means potassium. The suffix “septine” is derived from the Greek word “sepsis” ῆψις which means “decay” or “putrefaction”. This suffix was added to distinguish it from the related toxin kalicludine. Kaliseptine was first isolated from the snakelocks anemone, which at the time was called ''Anemonia sulcata''. Kaliseptine is abbreviated as AsKS, which stands for Anemonia sulcata KaliSeptine. The rational nomenclature of kaliseptine is kappa-actitoxin-Avd6a. The first letter Kappa indicates its molecular target, namely a voltage-gated potassium channel. Actitoxin is a neurotoxin derived from the Actiniidae. Avd denotes that it is extracted from '' Anemonia viridis''. Finally, 6a specifies that this was t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotoxin
Neurotoxins are toxins that are destructive to nerve tissue (causing neurotoxicity). Neurotoxins are an extensive class of exogenous chemical neurological insultsSpencer 2000 that can adversely affect function in both developing and mature nervous tissue.Olney 2002 The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove neurologically toxic. Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems. Common examples of neurotoxins include lead, ethanol (drinking alcohol), glutamate,Choi 1987 nitric oxide, botulinum toxin (e.g. Botox), tetanus toxin,Simpson 1986 and tetrodotoxin. Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations. Neurotoxins inhibit neuron control over ion concentrations across the cell membrane, or com ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actinia Equina Toxin
''Actinia'' is a genus of sea anemones in the family Actiniidae. Actinia display a rare form of heteromorphosis in which a cut inflicted on a specimen can develop into a second mouth. Species The following species are listed in the World Register of Marine Species (WoRMS): *''Actinia alba'' Risso, 1826 *'' Actinia annulata'' Gay, 1854 *'' Actinia aster'' Ellis, 1768 *'' Actinia australiensis'' Carlgren, 1950 *'' Actinia bermudensis'' (McMurrich, 1889) *''Actinia bicornis'' Müller, 1776 *''Actinia capillata'' Gay, 1854 *''Actinia cari'' Delle Chiaje, 1822 *''Actinia chlorodactyla'' Brandt, 1835 *'' Actinia cinerea'' Gay, 1854 *''Actinia cleopatrae'' Hemprich & Ehrenberg, 1834 *'' Actinia curta'' Drayton in Dana, 1846 *'' Actinia delicatula'' (Hertwig, 1888) *'' Actinia dubia'' Lesson, 1830 *'' Actinia ebhayiensis'' Schama, Mitchell & Solé-Cava, 2011 * Beadlet anemone (''Actinia equina'' ( Linnaeus, 1758)) *'' Actinia erythrospilota'' Brandt, 1835 *'' Actinia fiscella'' Müller, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotoxins
Neurotoxins are toxins that are destructive to nerve tissue (causing neurotoxicity). Neurotoxins are an extensive class of exogenous chemical neurological insultsSpencer 2000 that can adversely affect function in both developing and mature nervous tissue.Olney 2002 The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove neurologically toxic. Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems. Common examples of neurotoxins include lead, ethanol (drinking alcohol), glutamate,Choi 1987 nitric oxide, botulinum toxin (e.g. Botox), tetanus toxin,Simpson 1986 and tetrodotoxin. Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive concentrations. Neurotoxins inhibit neuron control over ion concentrations across the cell membrane, or c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nematocyst
A cnidocyte (also known as a cnidoblast or nematocyte) is an explosive cell containing one large secretory organelle called a cnidocyst (also known as a cnida () or nematocyst) that can deliver a sting to other organisms. The presence of this cell defines the phylum Cnidaria (corals, sea anemones, hydrae, jellyfish, etc.). Cnidae are used to capture prey and as a defense against predators. A cnidocyte fires a structure that contains a toxin within the cnidocyst; this is responsible for the stings delivered by a cnidarian. Structure and function Each cnidocyte contains an organelle called a cnida, cnidocyst, nematocyst, ptychocyst or spirocyst. This organelle consists of a bulb-shaped capsule containing a coiled hollow tubule structure attached to it. An immature cnidocyte is referred to as a cnidoblast or nematoblast. The externally oriented side of the cell has a hair-like trigger called a cnidocil, which is a mechano- and chemo-receptor. When the trigger is activated, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mammalian
Mammals () are a group of vertebrate animals constituting the class (biology), class Mammalia (), characterized by the presence of mammary glands which in Female#Mammalian female, females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or hair, and three ossicles, middle ear bones. These characteristics distinguish them from reptiles (including birds) from which they Genetic divergence, diverged in the Carboniferous, over 300 million years ago. Around 6,400 extant taxon, extant species of mammals have been described divided into 29 Order (biology), orders. The largest Order (biology), orders, in terms of number of species, are the rodents, bats, and Eulipotyphla (hedgehogs, Mole (animal), moles, shrews, and others). The next three are the Primates (including humans, apes, monkeys, and others), the Artiodactyla (cetaceans and even-toed ungulates), and the Carnivora (cats, dogs, pinniped, seals, and others). In terms of cladistic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter plates. Studies conducted using components of an organism that have been isolated from their usual biological surroundings permit a more detailed or more convenient analysis than can be done with whole organisms; however, results obtained from ''in vitro'' experiments may not fully or accurately predict the effects on a whole organism. In contrast to ''in vitro'' experiments, ''in vivo'' studies are those conducted in living organisms, including humans, and whole plants. Definition ''In vitro'' ( la, in glass; often not italicized in English usage) studies are conducted using components of an organism that have been isolated fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Action Potential
An action potential occurs when the membrane potential of a specific cell location rapidly rises and falls. This depolarization then causes adjacent locations to similarly depolarize. Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, and in some plant cells. Certain endocrine cells such as pancreatic beta cells, and certain cells of the anterior pituitary gland are also excitable cells. In neurons, action potentials play a central role in cell-cell communication by providing for—or with regard to saltatory conduction, assisting—the propagation of signals along the neuron's axon toward synaptic boutons situated at the ends of an axon; these signals can then connect with other neurons at synapses, or to motor cells or glands. In other types of cells, their main function is to activate intracellular processes. In muscle cells, for example, an action potential is the first step in the chain of events l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
KCNA2
Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the ''KCNA2'' gene. Function Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of thi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dendrotoxin
Dendrotoxins are a class of presynaptic neurotoxins produced by mamba snakes (''Dendroaspis'') that block particular subtypes of voltage-gated potassium channels in neurons, thereby enhancing the release of acetylcholine at neuromuscular junctions. Because of their high potency and selectivity for potassium channels, dendrotoxins have proven to be extremely useful as pharmacological tools for studying the structure and function of these ion channel proteins. Functional effects in the nervous system Dendrotoxins have been shown to block particular subtypes of voltage-gated potassium (K+) channels in neuronal tissue. In the nervous system, voltage-gated K+ channels control the excitability of nerves and muscles by controlling the resting membrane potential and by repolarizing the membrane during action potentials. Dendrotoxin has been shown to bind the nodes of Ranvier of motor neurons and to block the activity of these potassium channels. In this way, dendrotoxins prolong the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orthologs
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene transfer event (xenologs). Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity. Significant similarity is strong evidence that two sequences are related by evolutionary changes from a common ancestral sequence. Alignments of multiple sequences are used to indicate which regions of each sequence are homologous. Identity, similarity, and conservation The term "percent homology" is often used to mean "sequence similarity”, that is the percentage of identical residues (''percent identity''), or the percentage of residues conserved with similar physicochemical properties ('' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Potassium Channel
Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Function Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly (up to the diffusion rate of K+ ions in bulk water) and selectively (excluding, most notably, sodium despite the sub-angstrom difference in ionic radius). Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such as neurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the cardiac action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone. They also regulate ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stichodactyla Toxin
Stichodactyla toxin (ShK, ShkT) is a 35-residue Base (chemistry), basic peptide from the sea anemone ''Stichodactyla helianthus'' that blocks a number of potassium channels. Related peptides form a conserved protein family, family of protein domains known as the ShkT domain. Another well-studied toxin of the family is BgK from ''Bunodosoma granulifera''. An analogue of ShK called ShK-186 or Dalazatide is in human trials as a therapeutic for autoimmune diseases. History ''Stichodactyla helianthus'' is a species of sea anemone (Phylum: Cnidaria) belonging to the family ''Stichodactylidae''. ''Helianthus'' comes from the ancient Greek, Greek words helios meaning sun, and anthos meaning flower, which corresponds to the species' common name "sun anemone". It is sessile and uses potent neurotoxins for defense against its primary predator, the spiny lobster. The venom contains, among other components, numerous Channel blocker, ion channel-blocking peptides. In 1995, a group led by Ol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
