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Knemometry
Knemometry ( gr, η κνημη, i knimi, the lower leg) is the medical term for measuring the distance between knee and heel of a sitting child or adolescent using a technical device, the knemometer. Knemometric measurements show a measurement error of less than 160 μm (0.16 mm) and enable illustrating growth at intervals of few weeks (short-term growth). The device Ignaz Maria Valk developed this technique in 1983 in Nijmegen/ Netherlands. It is being practiced since and used for basic research in growth and the treatment of growth disorders. Hermanussen introduced the mini-knemometer for accurate growth measurements of prematures and newborn infants. Mini-knemometry determines the lower leg length with an accuracy of less than 100 μm (0.1 mm). This enables substantiating growth within 24 hours. In an animal model, the technique was used to investigate the effects of steroids and growth hormone on short-term growth. These studies were an important prerequisit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Hermanussen
Michael Hermanussen (born 26 April 1955 in Hamburg) is a German pediatrician and professor at the University of Kiel. He is known for his work on growth and nutrition. Life Hermanussen studied medicine and worked as a pediatrician at the University of Kiel from 1982 until 1989. He investigated growth and child development (auxology) and first described mini growth spurts. Since 1990 he cooperates in international joint projects with scientists and also works in a general pediatric office. He organizes national and international meetings on growth and nutrition. From 2003 to 2011 he was a member of the scientific board of the German society for Anthropology and chief editor of ”Anthropologischer Anzeiger”. He is the founder and head of the German society for auxology. Scientific Work Hermanussen developed new mathematical methods for improved diagnostics of growth disorders and a new technique for estimating final adult height. He developed mini- knemometry, a new and accurate t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lower Leg
The human leg, in the general word sense, is the entire lower limb of the human body, including the foot, thigh or sometimes even the hip or gluteal region. However, the definition in human anatomy refers only to the section of the lower limb extending from the knee to the ankle, also known as the crus or, especially in non-technical use, the shank. Legs are used for standing, and all forms of locomotion including recreational such as dancing, and constitute a significant portion of a person's mass. Female legs generally have greater hip anteversion and tibiofemoral angles, but shorter femur and tibial lengths than those in males. Structure In human anatomy, the lower leg is the part of the lower limb that lies between the knee and the ankle. Anatomists restrict the term ''leg'' to this use, rather than to the entire lower limb. The thigh is between the hip and knee and makes up the rest of the lower limb. The term ''lower limb'' or ''lower extremity'' is commonly used to descri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Growth Disorders
Growth hormone therapy refers to the use of growth hormone (GH) as a prescription medication—it is one form of hormone therapy. Growth hormone is a peptide hormone secreted by the pituitary gland that stimulates growth and cell reproduction. In the past, growth hormone was extracted from human pituitary glands. Growth hormone is now produced by recombinant DNA technology and is prescribed for a variety of reasons. GH therapy has been a focus of social and ethical controversies for 50 years. This article describes the history of GH treatment and the current uses and risks arising from GH use. Other articles describe GH physiology, diseases of GH excess ( acromegaly and pituitary gigantism), deficiency, the recent phenomenon of HGH controversies, growth hormone in sports, and growth hormone for cows. Medical uses HGH deficiency in children Growth hormone deficiency is treated by replacing growth hormone. Lonapegsomatropin was approved for medical use in the United States in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catch-up Growth
Compensatory growth, known as catch-up growth and compensatory gain, is an accelerated growth of an organism following a period of slowed development, particularly as a result of nutrient deprivation. The growth may be with respect to weight or length (or height in humans). For example, oftentimes the body weights of animals who experience nutritional restriction will over time become similar to those of animals who did not experience such stress. It is possible for high compensatory growth rates to result in overcompensation, where the organism exceeds normal weight and often has excessive fat deposition. An organism can recover to normal weight without additional time. Sometimes when the nutrient restriction is severe, the growth period is extended to reach the normal weight. If the nutrient restriction is severe enough, the organism may have permanent stunted growth where it does not ever reach normal weight. Usually in animals, complete recovery from carbohydrate and protei ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Auxology
Auxology,(from Greek , ''auxō'', or , ''auxanō'', "grow"; and , ''-logia''), is a meta-term covering the study of all aspects of human physical growth. (Although, it is also fundamental of biology.) Auxology is a multi-disciplinary science involving health sciences/medicine (pediatrics, general practice, endocrinology, neuroendocrinology, physiology, epidemiology), and to a lesser extent: nutrition science, genetics, anthropology, anthropometry, ergonomics, history, economic history, economics, socio-economics, sociology, public health, and psychology, among others. History of auxology ''""Ancient Babylonians and Egyptians left some writings on child growth and variation in height between ethnic groups. In the late 18th century, scattered documents of child growth started to appear in the scientific literature, the studies of Jamberts in 1754 and the annual measurements of the son of Montbeillard published by Buffon in 1777 being the most cited ones Louis René Villermé (1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Growth Hormone
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. GH also stimulates production of IGF-1 and increases the concentration of glucose and free fatty acids. It is a type of mitogen which is specific only to the receptors on certain types of cells. GH is a 191-amino acid, single-chain polypeptide that is synthesized, stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. A recombinant form of hGH called somatropin (INN) is used as a prescription drug to treat children's growth disorders and adult growth hormone deficiency. In the United States, it is only available legally from pharmacies by prescription from a licensed health care provider. In recent years in the United States, some health care providers are prescribing growth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroids
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signaling molecules. Hundreds of steroids are found in plants, animals and fungi. All steroids are manufactured in cells from the sterols lanosterol (opisthokonts) or cycloartenol (plants). Lanosterol and cycloartenol are derived from the cyclization of the triterpene squalene. The steroid core structure is typically composed of seventeen carbon atoms, bonded in four " fused" rings: three six-member cyclohexane rings (rings A, B and C in the first illustration) and one five-member cyclopentane ring (the D ring). Steroids vary by the functional groups attached to this four-ring core and by the oxidation state of the rings. Sterols are forms of steroids with a hydroxy group at position three and a skeleton derived from cholestane. '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infants
An infant or baby is the very young offspring of human beings. ''Infant'' (from the Latin word ''infans'', meaning 'unable to speak' or 'speechless') is a formal or specialised synonym for the common term ''baby''. The terms may also be used to refer to juveniles of other organisms. A newborn is, in colloquial use, an infant who is only hours, days, or up to one month old. In medical contexts, a newborn or neonate (from Latin, ''neonatus'', newborn) is an infant in the first 28 days after birth; the term applies to premature, full term, and postmature infants. Before birth, the offspring is called a fetus. The term ''infant'' is typically applied to very young children under one year of age; however, definitions may vary and may include children up to two years of age. When a human child learns to walk, they are called a toddler instead. Other uses In British English, an ''infant school'' is for children aged between four and seven. As a legal term, ''infancy'' is more lik ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basic Research
Basic research, also called pure research or fundamental research, is a type of scientific research with the aim of improving scientific theories for better understanding and prediction of natural or other phenomena. In contrast, applied research uses scientific theories to develop technology or techniques which can be used to intervene and ''alter'' natural or other phenomena. Though often driven simply by curiosity,"Curiosity creates cures: The value and impact of basic research , , |
Distance
Distance is a numerical or occasionally qualitative measurement of how far apart objects or points are. In physics or everyday usage, distance may refer to a physical length or an estimation based on other criteria (e.g. "two counties over"). Since spatial cognition is a rich source of conceptual metaphors in human thought, the term is also frequently used metaphorically to mean a measurement of the amount of difference between two similar objects (such as statistical distance between probability distributions or edit distance between strings of text) or a degree of separation (as exemplified by distance between people in a social network). Most such notions of distance, both physical and metaphorical, are formalized in mathematics using the notion of a metric space. In the social sciences, distance can refer to a qualitative measurement of separation, such as social distance or psychological distance. Distances in physics and geometry The distance between physical loca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Netherlands
) , anthem = ( en, "William of Nassau") , image_map = , map_caption = , subdivision_type = Sovereign state , subdivision_name = Kingdom of the Netherlands , established_title = Before independence , established_date = Spanish Netherlands , established_title2 = Act of Abjuration , established_date2 = 26 July 1581 , established_title3 = Peace of Münster , established_date3 = 30 January 1648 , established_title4 = Kingdom established , established_date4 = 16 March 1815 , established_title5 = Liberation Day (Netherlands), Liberation Day , established_date5 = 5 May 1945 , established_title6 = Charter for the Kingdom of the Netherlands, Kingdom Charter , established_date6 = 15 December 1954 , established_title7 = Dissolution of the Netherlands Antilles, Caribbean reorganisation , established_date7 = 10 October 2010 , official_languages = Dutch language, Dutch , languages_type = Regional languages , languages_sub = yes , languages = , languages2_type = Reco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nijmegen
Nijmegen (;; Spanish and it, Nimega. Nijmeegs: ''Nimwèège'' ) is the largest city in the Dutch province of Gelderland and tenth largest of the Netherlands as a whole, located on the Waal river close to the German border. It is about 60 km south east of Utrecht and 50 km north east of Eindhoven. Nijmegen is the oldest city in the Netherlands, the second to be recognized as such in Roman times, and in 2005 celebrated 2,000 years of existence. Nijmegen became a free imperial city in 1230 and in 1402 a Hanseatic city. Since 1923 it has been a university city with the opening of a Catholic institution now known as the Radboud University Nijmegen. The city is well known for the International Four Days Marches Nijmegen event. Its population in 2022 was 179,000; the municipality is part of the Arnhem–Nijmegen metropolitan area, with 736,107 inhabitants in 2011. Population centres The municipality is formed by the city of Nijmegen, incorporating the former villages of Ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
