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Immunoglobulin Heavy Chain
The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin). In human genome, the IgH gene loci are on chromosome 14. A typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. Several different types of heavy chain exist that define the class or isotype of an antibody. These heavy chain types vary between different animals. All heavy chains contain a series of immunoglobulin domains, usually with one variable domain (VH) that is important for binding antigen and several constant domains (CH1, CH2, etc.). Production of a viable heavy chain is a key step in B cell maturation. If the heavy chain is able to bind to a surrogate light chain and move to the plasma membrane, then the developing B cell can begin producing its light chain. The heavy chain doesn't always have to bind to a light chain. Pre-B lymphocytes can synthesize heavy chain in the absence of light chain, which then can allow the heavy ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ruminant
Ruminants (suborder Ruminantia) are ungulate, hoofed herbivorous grazing or browsing mammals that are able to acquire nutrients from plant-based food by Enteric fermentation, fermenting it in a specialized stomach prior to digestion, principally through microbial actions. The process, which takes place in the front part of the digestive system and therefore is called foregut fermentation, typically requires the fermented ingesta (known as cud) to be regurgitated and chewed again. The process of rechewing the cud to further break down plant matter and stimulate digestion is called rumination. The word "ruminant" comes from the Latin ''ruminare'', which means "to chew over again". The roughly 200 species of ruminants include both domestic and wild species. Ruminating mammals include cattle, all domesticated and wild bovines, goats, sheep, giraffes, deer, gazelles, and antelopes.Fowler, M.E. (2010).Medicine and Surgery of Camelids, Ames, Iowa: Wiley-Blackwell. Chapter 1 General Biolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single-domain Antibodies
A single-domain antibody (sdAb), also known as a nanobody, is an antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind selectively to a specific antigen. With a molecular weight of only 12–15 kDa, single-domain antibodies are much smaller than common antibodies (150–160 kDa) which are composed of two heavy protein chains and two light chains, and even smaller than Fab fragments (~50 kDa, one light chain and half a heavy chain) and single-chain variable fragments (~25 kDa, two variable domains, one from a light and one from a heavy chain). The first single-domain antibodies were engineered from heavy-chain antibodies found in camelids; these are called VHH fragments. Cartilaginous fishes also have heavy-chain antibodies (IgNAR, 'immunoglobulin new antigen receptor'), from which single-domain antibodies called VNAR fragments can be obtained. An alternative approach is to split the dimeric variable domains from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heavy-chain Antibody
A heavy-chain antibody is an antibody which consists only of two heavy chains and lacks the two light chains usually found in antibodies. In common antibodies, the antigen binding region consists of the variable domains of the heavy and light chains (VH and VL). Heavy-chain antibodies can bind antigens despite having only VH domains. This observation has led to the development of a new type of antibody fragments with potential use as drugs, so-called single-domain antibodies. Discovery In 1989 a group of biologists led by Raymond Hamers at the Free University Brussels investigated the immune system of dromedaries. In addition to the expected four-chain antibodies, they identified simpler antibodies consisting only of two heavy chains. This discovery was published in ''Nature'' in 1993. In 1995 a research team at the University of Miami found a different type of heavy-chain antibodies in sharks. In cartilaginous fishes The immunoglobulin new antigen receptor (IgNAR) of carti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cartilaginous Fish
Chondrichthyes (; ) is a class that contains the cartilaginous fishes that have skeletons primarily composed of cartilage. They can be contrasted with the Osteichthyes or ''bony fishes'', which have skeletons primarily composed of bone tissue. Chondrichthyes are jawed vertebrates with paired fins, paired nares, scales, and a heart with its chambers in series. Extant chondrichthyes range in size from the 10 cm (3.9 in) finless sleeper ray to the 10 m (32 ft) whale shark. The class is divided into two subclasses: Elasmobranchii (sharks, rays, skates, and sawfish) and Holocephali ( chimaeras, sometimes called ghost sharks, which are sometimes separated into their own class). Within the infraphylum Gnathostomata, cartilaginous fishes are distinct from all other jawed vertebrates. Anatomy Skeleton The skeleton is cartilaginous. The notochord is gradually replaced by a vertebral column during development, except in Holocephali, where the notochord stays intact. In some deepw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isotype (immunology)
In immunology, antibodies ( immunoglobulins (Ig)) are classified into several types called isotypes or classes. The variable (V) regions near the tip of the antibody can differ from molecule to molecule in countless ways, allowing it to specifically target an antigen (or more exactly, an epitope). In contrast, the constant (C) regions only occur in a few variants, which define the antibody's class. Antibodies of different classes activate distinct effector mechanisms in response to an antigen (triggering different elements of the innate immune system). They appear at different stages of an immune response, differ in structural features, and in their location around the body. Isotype expression reflects the maturation stage of a B cell. Naive B cells express IgM and IgD isotypes with unmutated variable genes, which are produced from the same initial transcript following alternative splicing. Expression of other antibody isotypes (in humans: IgG, IgA, and IgE) occurs via a process ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zebrafish
The zebrafish (''Danio rerio'') is a freshwater fish belonging to the minnow family ( Cyprinidae) of the order Cypriniformes. Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (and thus often called a "tropical fish" although both tropical and subtropical). It is also found in private ponds. The zebrafish is an important and widely used vertebrate model organism in scientific research, for example in drug development, in particular pre-clinical development. It is also notable for its regenerative abilities, and has been modified by researchers to produce many transgenic strains. Taxonomy The zebrafish is a derived member of the genus '' Brachydanio'', of the family Cyprinidae. It has a sister-group relationship with ''Danio aesculapii''. Zebrafish are also closely related to the genus ''Devario'', as demonstrated by a phylogenetic tree of close species. Distribution Range The zebrafish is native to fresh water h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rainbow Trout
The rainbow trout (''Oncorhynchus mykiss'') is a species of trout native to cold-water tributaries of the Pacific Ocean in Asia and North America. The steelhead (sometimes called "steelhead trout") is an anadromous (sea-run) form of the coastal rainbow trout or Columbia River redband trout that usually returns to freshwater to spawn after living two to three years in the ocean. Freshwater forms that have been introduced into the Great Lakes and migrate into tributaries to spawn are also called steelhead. Adult freshwater stream rainbow trout average between , while lake-dwelling and anadromous forms may reach . Coloration varies widely based on subspecies, forms, and habitat. Adult fish are distinguished by a broad reddish stripe along the lateral line, from gills to the tail, which is most vivid in breeding males. Wild-caught and hatchery-reared forms of the species have been transplanted and introduced for food or sport in at least 45 countries and every continent except ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atlantic Salmon
The Atlantic salmon (''Salmo salar'') is a species of ray-finned fish in the family Salmonidae. It is the third largest of the Salmonidae, behind Siberian taimen and Pacific Chinook salmon, growing up to a meter in length. Atlantic salmon are found in the northern Atlantic Ocean and in rivers that flow into it. Most populations are anadromous, hatching in streams and rivers but moving out to sea as they grow where they mature, after which the adults seasonally move upstream again to spawn. When the mature fish re-enter rivers to spawn, they change in colour and appearance. Some populations of this fish only migrate to large lakes, and are "landlocked", spending their entire lives in freshwater. Such populations are found throughout the range of the species. Unlike Pacific species of salmon, ''S. salar'' is iteroparous, which means it can survive spawning and return to sea to repeat the process again in another year. Such individuals can grow to extremely large sizes, althoug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Channel Catfish
The channel catfish (''Ictalurus punctatus'') is North America's most numerous catfish species. It is the official fish of Kansas, Missouri, Iowa, Nebraska, and Tennessee, and is informally referred to as a "channel cat". In the United States, they are the most fished catfish species with around 8 million anglers targeting them per year. The popularity of channel catfish for food has contributed to the rapid expansion of aquaculture of this species in the United States. It has also been widely introduced in Europe, Asia and South America, and it is legally considered an invasive species in many countries. Distribution and habitat Channel catfish are native to the Nearctic, being well distributed in lower Canada and the eastern and northern United States, as well as parts of northern Mexico. They have also been introduced into some waters of landlocked Europe (Czech Republic and Romania) and parts of Malaysia and almost as many parts of Indonesia. They thrive in small and large ri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pentamer
A pentamer is an entity composed of five sub-units. In chemistry, it applies to molecules made of five monomers. In biochemistry, it applies to macromolecules, in particular to pentameric proteins, made of five proteic sub-units. In microbiology, a pentamer is one of the proteins composing the polyhedral protein shell that encloses the bacterial micro-compartments known as carboxysomes. In immunology, an MHC pentamer is a reagent used to detect antigen-specific CD8+ T cells. See also * penta prefix * -mer suffix * ''Pentamerous Metamorphosis'', an album by Global Communication * Pentamery (botany), having five parts in a distinct whorl of a plant structure * Pentamerous can also refer to animals, such as crinoids Crinoids are marine animals that make up the class Crinoidea. Crinoids that are attached to the sea bottom by a stalk in their adult form are commonly called sea lilies, while the unstalked forms are called feather stars or comatulids, which are ... Oligomer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teleost
Teleostei (; Greek ''teleios'' "complete" + ''osteon'' "bone"), members of which are known as teleosts ), is, by far, the largest infraclass in the class Actinopterygii, the ray-finned fishes, containing 96% of all extant species of fish. Teleosts are arranged into about 40 orders and 448 family (biology), families. Over 26,000 species have been described. Teleosts range from giant oarfish measuring or more, and ocean sunfish weighing over , to the minute male anglerfish ''Photocorynus spiniceps'', just long. Including not only torpedo-shaped fish built for speed, teleosts can be flattened vertically or horizontally, be elongated cylinders or take specialised shapes as in anglerfish and seahorses. The difference between teleosts and other bony fish lies mainly in their jaw bones; teleosts have a movable premaxilla and corresponding modifications in the jaw musculature which make it possible for them to cranial kinesis, protrude their jaws outwards from the mouth. This is of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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