|
Idiotype
In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T-cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The variable region of antigen receptors of T cells (TCRs) and B cells (immunoglobulins) contain complementarity-determining regions (CDRs) with unique amino acid sequences. They define the surface and properties of the variable region, determining the antigen specificity and therefore the idiotope of the molecule. Immunoglobulins or TCRs with a shared idiotope are the same idiotype. Antibody idiotype is determined by: *Gene rearrangement *Junctional diversity *P-nucleotides (palindromic nucleotides at sites of single-strand breaks) *N-nucleotides *Somatic hypermutations Etymology and usage The word idiotype comes from two Greek roots, ''idio'' meaning 'private, distinctive, peculiar' and ''typos'' meaning 'mark.' Thus, idiotype describes the distinctive sequence and re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Network Theory
The immune network theory is a theory of how the adaptive immune system works, that has been developed since 1974 mainly by Niels Jerne and Geoffrey W. Hoffmann. The theory states that the immune system is an interacting network of lymphocytes and molecules that have variable (V) regions. These V regions bind not only to things that are foreign to the vertebrate, but also to other V regions within the system. The immune system is therefore seen as a network, with the components connected to each other by V-V interactions. It has been suggested that the phenomena that the theory describes in terms of networks are also explained by clonal selection theory. The scope of the symmetrical network theory developed by Hoffmann includes the phenomena of low dose and high dose tolerance, first reported for a single antigen by Avrion Mitchison,N. A. Mitchison (1964) Induction of immunological paralysis in two zones of dosage. Proc. Royal Soc. Lond. B161, 275-292 and confirmed by Geoffrey She ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Network Theory
The immune network theory is a theory of how the adaptive immune system works, that has been developed since 1974 mainly by Niels Jerne and Geoffrey W. Hoffmann. The theory states that the immune system is an interacting network of lymphocytes and molecules that have variable (V) regions. These V regions bind not only to things that are foreign to the vertebrate, but also to other V regions within the system. The immune system is therefore seen as a network, with the components connected to each other by V-V interactions. It has been suggested that the phenomena that the theory describes in terms of networks are also explained by clonal selection theory. The scope of the symmetrical network theory developed by Hoffmann includes the phenomena of low dose and high dose tolerance, first reported for a single antigen by Avrion Mitchison,N. A. Mitchison (1964) Induction of immunological paralysis in two zones of dosage. Proc. Royal Soc. Lond. B161, 275-292 and confirmed by Geoffrey She ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isotype (immunology)
In immunology, antibodies ( immunoglobulins (Ig)) are classified into several types called isotypes or classes. The variable (V) regions near the tip of the antibody can differ from molecule to molecule in countless ways, allowing it to specifically target an antigen (or more exactly, an epitope). In contrast, the constant (C) regions only occur in a few variants, which define the antibody's class. Antibodies of different classes activate distinct effector mechanisms in response to an antigen (triggering different elements of the innate immune system). They appear at different stages of an immune response, differ in structural features, and in their location around the body. Isotype expression reflects the maturation stage of a B cell. Naive B cells express IgM and IgD isotypes with unmutated variable genes, which are produced from the same initial transcript following alternative splicing. Expression of other antibody isotypes (in humans: IgG, IgA, and IgE) occurs via a process ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allotype (immunology)
The word allotype comes from two Greek roots, ''allo'' meaning 'other or differing from the norm' and ''typos'' meaning 'mark'. In immunology, allotype is an immunoglobulin variation (in addition to isotypic variation) that can be found among antibody classes and is manifested by heterogeneity of immunoglobulins present in a single vertebrate species. The structure of immunoglobulin polypeptide chain is dictated and controlled by number of genes encoded in the germ line. However, these genes, as it was discovered by serologic and chemical methods, could be highly polymorphic. This polymorphism is subsequently projected to the overall amino acid structure of antibody chains. Polymorphic epitopes can be present on immunoglobulin constant regions on both heavy and light chains, differing between individuals or ethnic groups and in some cases may pose as immunogenic determinants. Exposure of individuals to a non-self allotype might elicit an anti- allotype response and became ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Niels Jerne
Niels is a male given name, equivalent to Nicholas, which is common in Denmark, Belgium, Norway (formerly) and the Netherlands. The Norwegian and Swedish variant is Nils. The name is a developed short form of Nicholas or Greek Nicolaos after Saint Nicholas. Its pet form is Nisse, and female variants are Nielsine, Nielsina, and Nielsa. Niels may refer to: People *Niels, King of Denmark (1065–1134) *Niels, Count of Halland (died 1218) * Niels Aagaard (1612–1657), Danish poet *Niels Aall (1769–1854), Norwegian businessman and politician *Niels Henrik Abel (1802–1829), Norwegian mathematician *Niels Arestrup (born 1949), French actor *Niels Viggo Bentzon (1919–2000), Danish composer and pianist *Niels Bohr (1885–1962), Danish physicist and Nobel Prize recipient *Niels Busk (born 1942), Danish politician *Niels Ebbesen (died 1340), Danish squire and national hero *Niels Feijen (born 1977), Dutch pool player * Niels Ferguson (born 1965), Dutch cryptographer *Niels Friis (d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical University Of South Carolina
The Medical University of South Carolina (MUSC) is a public medical school in South Carolina. It opened in 1824 in Charleston as a small private college aimed at training physicians and has since established hospitals and medical facilities across the state. It is one of the oldest continually operating schools of medicine in the United States and the oldest in the Deep South. The school's main building was designed by Charleston architect Albert W. Todd. The school has expanded into a state university with a medical center and six colleges for the education of health professionals, biomedical scientists, and other health care personnel. It also operates as a center for research and has a public hospital. Colleges College of Medicine History The College of Medicine began in 1823 with the incorporation of the Medical College of South Carolina, a private institution of the Medical Society of South Carolina. Seven Charleston physicians formed the initial faculty with 30 stude ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paratope
In immunology, a paratope, also known as an antigen-binding site, is the part of an antibody which recognizes and binds to an antigen. It is a small region at the tip of the antibody's antigen-binding fragment and contains parts of the antibody's heavy and light chains. Each paratope is made up of six complementarity-determining regions - three from each of the light and heavy chains - that extend from a fold of anti-parallel beta sheets. Each arm of the Y-shaped antibody has an identical paratope at the end. Paratopes make up the parts of the B-cell receptor that bind to and make contact with the epitope of an antigen. All the B-cell receptors on one B cell have identical paratopes. The uniqueness of a paratope allows it to bind to only one epitope with high affinity and as a result, each B cell can only respond to one epitope. The paratopes on B-cell receptors binding to their specific epitope is a critical step in the adaptive immune response. Design of paratopes between spec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epitope
An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a paratope. Although epitopes are usually non-self proteins, sequences derived from the host that can be recognized (as in the case of autoimmune diseases) are also epitopes. The epitopes of protein antigens are divided into two categories, conformational epitopes and linear epitopes, based on their structure and interaction with the paratope. Conformational and linear epitopes interact with the paratope based on the 3-D conformation adopted by the epitope, which is determined by the surface features of the involved epitope residues and the shape or tertiary structure of other segments of the antigen. A conformational epitope is formed by the 3-D conformation adopted by the interac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Physiology Or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace. The Nobel Prize is presented annually on the anniversary of Alfred Nobel's death, 10 December. As of 2022, 114 Nobel Prizes in Physiology or Medicine have been awarded to 226 laureates, 214 men and 12 women. The first one was awarded in 1901 to the German physiologist, Emil von Behring, for his work on serum therapy and the development of a vaccine against diphtheria. The first woman to receive the Nobel Prize in Physiology or Medicine, Gerty Cori, received it in 1947 for her role in elucidati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Idiotope
In immunology, an idiotope is the unique set of antigenic determinants (epitopes) of the variable portion of an antibody. In some cases it can be the actual antigen-binding site, and in some cases it may comprise variable region sequences outside of the antigen-binding site on the antibody itself. Thus each antibody would have multiple idiotopes; and the set of these individual idiotopes is termed the ''idiotype'' of the antibody. Idiotopes contrast with allotopes, which are non-varying structures on the Fc receptor. If a separate antibody is produced that has specific binding capabilities to an idiotope of the previously described antibody, it is said to be an "anti-idiotypic antibody". If such is the case, the anti-idiotypic antibodies will be able to bind to the B lymphocyte receptor for the original antigen and inhibit the immune response to that antigen. This type of regulation was proposed by Danish immunologist Niels Jerne in 1974. He termed it the "Network Hypothesis". ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunology
Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there is a difference of human immunology and comparative immunology in veterinary medicine and animal biosciences. Immunology measures, uses charts and differentiate in context in medicine the studies of immunity on cell and molecular level, and the immune system as part of the physiological level as its functioning is of major importance. In the different states of both health, occurring symptoms and diseases; the functioning of the immune system and immunological responses such as autoimmune diseases, allergic hypersensitivities, or in some cases malfunctioning of immune system as for example in immunological disorders or in immune deficiency, and the specific transplant rejection) Immunology has applications in numerous disciplines of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
