Hygromycin B
Hygromycin B is an antibiotic produced by the bacterium '' Streptomyces hygroscopicus''. It is an aminoglycoside that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. History Hygromycin B was originally developed in the 1950s for use with animals and is still added into swine and chicken feed as an anthelmintic or anti-worming agent (product name: Hygromix). Hygromycin B is produced by ''Streptomyces hygroscopicus'', a bacterium isolated in 1953 from a soil sample. Resistance genes were discovered in the early 1980s. Mechanism of action Hygromycin is active against both prokaryotic and eukaryotic cells. It acts by inhibiting polypeptide synthesis. It stabilizes the tRNA-ribosomal acceptor site, thereby inhibiting translation. Use in research In the laboratory it is used for the selection and maintenance of prokaryotic and eukaryotic cells that contain the hygromycin resistance gene. The resistance gene is a kinase that inactivates hygr ...
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