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Hydroxyethylrutoside
Hydroxyethylrutosides (oxerutins, ''O''-beta-hydroxyethyl-rutosides, HR, or HER) are hydroxyethyl derivatives of rutosides. Examples include: * Monoxerutin * Dihydroxyethylrutoside * Troxerutin * Tetrahydroxyethylrutoside Oxerutins are semisynthetic derivatives of plant constituents. Although they are closely related to the natural flavonoid rutin, hydroxyethylrutosides are not found in food. The only way to take them is in a supplement. Health benefits Relvène (1967 French version), Venoruton (1962 Swiss version), and Paroven are mixtures of hydroxyethyl rutinosides. Hydroxyethylrutosides are used in the treatment of chronic venous insufficiency and hypertensive microangiopathy. Oxerutins work by reducing leakage from the small blood vessels (capillaries). Hydroxyethylrutosides have been used as an alternative to horse chestnut preparations ( venostasin) containing aescin. Typical doses are in the order of 1,000 mg/day. Effects of hydroxyethylrutosides against adria ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic Venous Insufficiency
Chronic venous insufficiency (CVI) is a medical condition in which blood pools in the veins, straining the walls of the vein. The most common cause of CVI is superficial venous reflux which is a treatable condition. As functional venous valves are required to provide for efficient blood return from the lower extremities, this condition typically affects the legs. If the impaired vein function causes significant symptoms, such as swelling and ulcer formation, it is referred to as chronic venous disease. It is sometimes called ''chronic peripheral venous insufficiency'' and should not be confused with post-thrombotic syndrome in which the deep veins have been damaged by previous deep vein thrombosis. Most cases of CVI can be improved with treatments to the superficial venous system or stenting the deep system. Varicose veins for example can now be treated by local anesthetic endovenous surgery. Rates of CVI are higher in women than in men. Other risk factors include genetics, smok ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Troxerutin
Troxerutin is a flavonol, a type of flavonoid, derived from rutin. It is more accurately a hydroxyethylrutoside. It can be isolated from ''Sophora japonica'', the Japanese pagoda tree. It is used as a vasoprotective. Troxerutin has been shown in mice to reverse CNS insulin resistance and reduce reactive oxygen species induced by a high-cholesterol diet. References Quercetin glycosides Flavonol rutinosides Phenol ethers {{cardiovascular-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydroxyethyl
Ethanol (abbr. EtOH; also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound. It is an Alcohol (chemistry), alcohol with the chemical formula . Its formula can be also written as or (an ethyl group linked to a hydroxyl group). Ethanol is a Volatility (chemistry), volatile, Combustibility and flammability, flammable, colorless liquid with a characteristic wine-like odor and pungent taste. It is a psychoactive recreational drug, the active ingredient in alcoholic drinks. Ethanol is naturally produced by the fermentation process of Carbohydrate, sugars by yeasts or via Petrochemistry, petrochemical processes such as ethylene hydration. It has medical applications as an antiseptic and disinfectant. It is used as a chemical solvent and in the Chemical synthesis, synthesis of organic compounds, and as a Alcohol fuel, fuel source. Ethanol also can be dehydrated to make ethylene, an important chemical feedstock. As of 2006, world produ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derivative (chemistry)
In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction. In the past, derivative also meant a compound that ''can be imagined to'' arise from another compound, if one atom or group of atoms is replaced with another atom or group of atoms, but modern chemical language now uses the term structural analog for this meaning, thus eliminating ambiguity. The term "structural analogue" is common in organic chemistry. In biochemistry, the word is used for compounds that at least theoretically can be formed from the precursor compound. Chemical derivatives may be used to facilitate analysis. For example, melting point (MP) analysis can assist in identification of many organic compounds. A crystalline derivative may be prepared, such as a semicarbazone or 2,4-dinitrophenylhydrazone (derived from aldehydes or ketones), as a simple way of verifying the identity of the original compound, assuming that a table of derivative MP values is available ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rutoside
Rutin, also called rutoside, quercetin-3-O-rutinoside and sophorin, is the glycoside combining the flavonol quercetin and the disaccharide rutinose (α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranose). It is a flavonoid found in a wide variety of plants, including citrus. Occurrences Rutin is one of the phenolic compounds found in the invasive plant species, ''Carpobrotus edulis''. Its name comes from the name of ''Ruta graveolens'', a plant that also contains rutin. Various citrus fruit peels contain 32 to 49 mg/g of flavonoids expressed as rutin equivalents. Citrus leaves contain rutin at concentrations of 11 and 7 g/kg in orange and lime trees, respectively. In 2021, Samoan researchers identified rutin in the native plant, ''matalafi'' (''Psychotria insularum''). Metabolism The enzyme quercitrinase found in ''Aspergillus flavus'' is in the rutin catabolic pathway. In food Rutin is a citrus flavonoid glycoside found in many plants, including buckwheat, the leaves and pet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monoxerutin
Monoxerutin is a flavonol, a type of flavonoid. It is more accurately a hydroxyethylrutoside Hydroxyethylrutosides (oxerutins, ''O''-beta-hydroxyethyl-rutosides, HR, or HER) are hydroxyethyl derivatives of rutosides. Examples include: * Monoxerutin * Dihydroxyethylrutoside * Troxerutin * Tetrahydroxyethylrutoside Oxerutins are semisyn .... References Quercetin glycosides Flavonol rutinosides Catechols Phenol ethers {{cardiovascular-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rutin
Rutin, also called rutoside, quercetin-3-O-rutinoside and sophorin, is the glycoside combining the flavonol quercetin and the disaccharide rutinose (α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranose). It is a flavonoid found in a wide variety of plants, including citrus. Occurrences Rutin is one of the phenolic compounds found in the invasive plant species, ''Carpobrotus edulis''. Its name comes from the name of ''Ruta graveolens'', a plant that also contains rutin. Various citrus fruit peels contain 32 to 49 mg/g of flavonoids expressed as rutin equivalents. Citrus leaves contain rutin at concentrations of 11 and 7 g/kg in orange and lime trees, respectively. In 2021, Samoan researchers identified rutin in the native plant, ''matalafi'' (''Psychotria insularum''). Metabolism The enzyme quercitrinase found in ''Aspergillus flavus'' is in the rutin catabolic pathway. In food Rutin is a citrus flavonoid glycoside found in many plants, including buckwheat, the leaves and pe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microangiopathy
Microangiopathy (also known as microvascular disease, small vessel disease (SVD) or microvascular dysfunction) is a disease of the microvessels, small blood vessels in the microcirculation. It can be contrasted to coronary heart disease, an angiopathy that affects the larger vessels. Type Cerebral small vessel disease refers to a group of diseases that affect the small arteries, arterioles, venules, and capillaries of the brain. Age-related and hypertension-related small vessel diseases and cerebral amyloid angiopathy are the most common forms. Coronary small vessel disease is a type of coronary heart disease that affects the arterioles and capillaries of the heart. Coronary small vessel disease is also known as microvascular angina, microvascular dysfunction, non-obstructive coronary disease, or previously ''cardiac syndrome X''. Pathophysiology One cause of microangiopathy is long-term diabetes mellitus. In this case, high blood glucose levels cause the endothelial cells linin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aescin
Aescin or escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in ''Aesculus hippocastanum'' (the horse chestnut). Aescin is the main active component in horse chestnut, and is responsible for most of its medicinal properties. The main active compound of aescin is β-aescin, although the mixture also contains various other components including α-aescin, protoescigenin, barringtogenol, cryptoescin and benzopyrones. Evidence suggests that aescin, especially pure β-aescin, is a safe and effective treatment for short-term treatment of chronic venous insufficiency; however, more high quality randomized controlled trials are required to confirm the effectiveness. Horse chestnut extract may be as effective and well tolerated as the use of compression stockings. Mechanism of action Aescin appears to produce effects through a wide range of mechanisms. It induces endothelial nitric oxide synthesis by making endothelial cells more p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
