Glyphosate Resistance
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Glyphosate Resistance
Glyphosate (IUPAC name: ''N''-(phosphonomethyl)glycine) is a broad-spectrum systemic herbicide and crop desiccant. It is an organophosphorus compound, specifically a phosphonate, which acts by inhibiting the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase. It is used to kill weeds, especially annual broadleaf weeds and grasses that compete with crops. Its herbicidal effectiveness was discovered by Monsanto chemist John E. Franz in 1970. Monsanto brought it to market for agricultural use in 1974 under the trade name Roundup. Monsanto's last commercially relevant United States patent expired in 2000. Farmers quickly adopted glyphosate for agricultural weed control, especially after Monsanto introduced glyphosate-resistant Roundup Ready crops, enabling farmers to kill weeds without killing their crops. In 2007, glyphosate was the most used herbicide in the United States' agricultural sector and the second-most used (after 2,4-D) in home and garden, government and ...
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Trimethylsulfonium
Trimethylsulfonium (systematically named trimethylsulfanium and trimethylsulfur(1+)) is an organic chemistry, organic cation with the chemical formula (CH3)3S+ (also written as ). Compounds Several salt (chemistry), salts of trimethylsulfonium are known. X-ray crystallography reveals that the sulfur is pyramidal, with C-S-C angles near 102° and C-S bond distance of 177 picometers. Unless the anion is colored, all trimethylsulfonium salts are white or colorless. Preparation Sulfonium compounds can be synthesised by treating a suitable alkyl halide with a thioether. For example, the reaction of dimethyl sulfide with iodomethane yields trimethylsulfonium iodide: :CH3–S–CH3 + CH3–I → (CH3)3SI Related An extra oxygen atom can bond to the sulfur atom to yield the trimethylsulfoxonium ion. Use Glyphosate herbicide is often supplied as a trimethylsulfonium salt. When mixed with aluminium bromide, or aluminium chloride or even hydrogen bromide, trimethylsulfonium bromide ...
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Pesticide Resistance
Pesticide resistance describes the decreased susceptibility of a pest population to a pesticide that was previously effective at controlling the pest. Pest species evolve pesticide resistance via natural selection: the most resistant specimens survive and pass on their acquired heritable changes traits to their offspring.PBS (2001)Pesticide resistance Retrieved on September 15, 2007. If a pest has ''resistance'' then the pesticide lacks ''efficacy'' efficacy and resistance are inversely related. Cases of resistance have been reported in all classes of pests (''i.e.'' crop diseases, weeds, rodents, ''etc.''), with 'crises' in insect control occurring early-on after the introduction of pesticide use in the 20th century. The Insecticide Resistance Action Committee (IRAC) definition of insecticide resistance is ''a heritable change in the sensitivity of a pest population that is reflected in the repeated failure of a product to achieve the expected level of control when used accordi ...
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Non-Hodgkin Lymphoma
Non-Hodgkin lymphoma (NHL), also known as non-Hodgkin's lymphoma, is a group of blood cancers that includes all types of lymphomas except Hodgkin lymphomas. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and tiredness. Other symptoms may include bone pain, chest pain, or itchiness. Some forms are slow-growing while others are fast-growing. Lymphomas are types of cancer that develop from lymphocytes, a type of white blood cell. Risk factors include poor immune function, autoimmune diseases, ''Helicobacter pylori'' infection, hepatitis C, obesity, and Epstein–Barr virus infection. The World Health Organization classifies lymphomas into five major groups, including one for Hodgkin lymphoma. Within the four groups for NHL are over 60 specific types of lymphoma. Diagnosis is by examination of a bone marrow or lymph node biopsy. Medical imaging is done to help with cancer staging. Treatment depends on whether the lymphoma is slow- or fast-growing an ...
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Federal Institute For Risk Assessment
The German Federal Institute for Risk Assessment (German: ''Bundesinstitut für Risikobewertung''), abbreviated BfR, is a body under public law of the German federal government with full legal capacity. The institute comes under the portfolio of the Federal Ministry of Food and Agriculture (German: ''Bundesministeriums für Ernährung und Landwirtschaft'', BMEL) and has the task of providing scientific advice to the federal government on issues relating to food safety, product safety, chemical safety, contaminants in the food chain, animal protection and consumer health protection. Further technical supervision is performed by the Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (chemicals safety, environmental contamination in feed and food) and the Federal Ministry of Transport (transport of hazardous goods, International Convention on Ballast Water Management, Central Command for Maritime Emergencies). Areas of responsibility The BfR ...
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Scientific Consensus
Scientific consensus is the generally held judgment, position, and opinion of the majority or the supermajority of scientists in a particular field of study at any particular time. Consensus is achieved through scholarly communication at conferences, the publication process, replication of reproducible results by others, scholarly debate, and peer review. A conference meant to create a consensus is termed as a consensus conference. Such measures lead to a situation in which those within the discipline can often recognize such a consensus where it exists; however, communicating to outsiders that consensus has been reached can be difficult, because the "normal" debates through which science progresses may appear to outsiders as contestation. On occasion, scientific institutes issue position statements intended to communicate a summary of the science from the "inside" to the "outside" of the scientific community, or consensus review articles or surveys may be published. In cases wh ...
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Acceptable Daily Intake
Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. ADIs are expressed usually in milligrams (of the substance) per kilograms of body weight per day. History This concept was first introduced in 1961 by the Council of Europe and later, the Joint FAO/WHO Expert Committee on Food Additives (JECFA), a committee maintained by two United Nations bodies: the Food and Agriculture Organization (FAO) and the World Health Organization (WHO). Concept An ADI value is based on current research, with long-term studies on animals and observations of humans. First, a no-observed-adverse-effect level (NOAEL), the amount of a substance that shows no toxic effects, is determined. Usually the studies are performed with several doses including high doses. In ...
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Food And Agriculture Organization
The Food and Agriculture Organization of the United Nations (FAO)french: link=no, Organisation des Nations unies pour l'alimentation et l'agriculture; it, Organizzazione delle Nazioni Unite per l'Alimentazione e l'Agricoltura is an international organization that leads international efforts to defeat hunger and improve nutrition and food security. Its Latin motto, ', translates to "let there be bread". It was founded on 16 October 1945. The FAO is composed of 195 members (including 194 countries and the European Union). Their headquarters is in Rome, Italy, and the FAO maintains regional and field offices around the world, operating in over 130 countries. It helps governments and development agencies coordinate their activities to improve and develop agriculture, forestry, fisheries, and land and water resources. It also conducts research, provides technical assistance to projects, operates educational and training programs, and collects data on agricultural output, produ ...
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Genetically Modified Soybean
A genetically modified soybean is a soybean (''Glycine max'') that has had DNA introduced into it using genetic engineering techniques. In 1996, the first genetically modified soybean was introduced to the U.S. by Monsanto. In 2014, 90.7 million hectares of GM soybeans were planted worldwide, this is almost 82% of the total soybeans cultivation area. Examples of transgenic soybeans The genetic makeup of a soybean gives it a wide variety of uses, thus keeping it in high demand. First, manufacturers only wanted to use transgenics to be able to grow more soybeans at a minimal cost to meet this demand, and to fix any problems in the growing process, but they eventually found they could modify the soybean to contain healthier components, or even focus on one aspect of the soybean to produce in larger quantities. These phases became known as the first and second generation of genetically modified (GM) foods. As Peter Celec describes, "benefits of the first generation of GM foods were ...
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Genetic Engineering
Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA is obtained by either isolating and copying the genetic material of interest using recombinant DNA methods or by artificially synthesising the DNA. A construct is usually created and used to insert this DNA into the host organism. The first recombinant DNA molecule was made by Paul Berg in 1972 by combining DNA from the monkey virus SV40 with the lambda virus. As well as inserting genes, the process can be used to remove, or "knock out", genes. The new DNA can be inserted randomly, or targeted to a specific part of the genome. An organism that is generated through genetic engineering is considered to be genetically modified (GM) an ...
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Preemergent Herbicides
Preemergent herbicides are a form of chemical weed control which prevent germinated weed seedlings from becoming established. In some areas of the world, they are used to prevent crabgrass from appearing in lawns. Preemergent herbicides are applied to lawns in the spring and fall, to prevent the germination of weed seeds. They will not affect any established plant. In the spring, they should be applied when air temperatures reach 65–70 °F for four consecutive days. In the fall, they should be applied when nighttime lows reach 55–60 °F for four consecutive nights. "Weed and feed" products which contain both preemergent herbicide and fertilizer in a single product should not be used on southern lawns or warm-season grasses. If applied when preemergent herbicide is needed, the fertilizer may burn or stress the lawn. If applied after the lawn "green-up", weed seeds will have already germinated and the herbicide will be ineffective. Preemergants do not prevent see ...
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Phenylalanine
Phenylalanine (symbol Phe or F) is an essential α-amino acid with the formula . It can be viewed as a benzyl group substituted for the methyl group of alanine, or a phenyl group in place of a terminal hydrogen of alanine. This essential amino acid is classified as neutral, and nonpolar because of the inert and hydrophobic nature of the benzyl side chain. The L-isomer is used to biochemically form proteins coded for by DNA. Phenylalanine is a precursor for tyrosine, the monoamine neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), and the skin pigment melanin. It is encoded by the codons UUU and UUC. Phenylalanine is found naturally in the milk of mammals. It is used in the manufacture of food and drink products and sold as a nutritional supplement for its analgesic and antidepressant effects. It is a direct precursor to the neuromodulator phenethylamine, a commonly used dietary supplement. As an essential amino acid, phenylalanine is n ...
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Tryptophan
Tryptophan (symbol Trp or W) is an α-amino acid that is used in the biosynthesis of proteins. Tryptophan contains an α-amino group, an α- carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromatic beta carbon substituent. It is essential in humans, meaning that the body cannot synthesize it and it must be obtained from the diet. Tryptophan is also a precursor to the neurotransmitter serotonin, the hormone melatonin, and vitamin B3. It is encoded by the codon UGG. Like other amino acids, tryptophan is a zwitterion at physiological pH where the amino group is protonated (–; pKa = 9.39) and the carboxylic acid is deprotonated ( –COO−; pKa = 2.38). Humans and many animals cannot synthesize tryptophan: they need to obtain it through their diet, making it an essential amino acid. Function Amino acids, including tryptophan, are used as building blocks in protein biosynthesis, and proteins are required to sustain life. Man ...
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