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Glycerol Phosphate
Glycerol phosphate may refer to: * Glycerol 1-phosphate * Glycerol 2-phosphate * Glycerol 3-phosphate ''sn''-Glycerol 3-phosphate is the organic ion with the formula HOCH2CH(OH)CH2OPO32-. It is one of three stereoisomers of the ester of dibasic phosphoric acid (HOPO32-) and glycerol. It is a component of glycerophospholipids. Equally appropriat ... {{chemistry index ...
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Glycerol 1-phosphate
''sn''-Glycerol 1-phosphate is the conjugate base of a phosphoric ester of glycerol. It is a component of ether lipids, which are common for archaea. Biosynthesis and metabolism Glycerol 1-phosphate is synthesized by reducing dihydroxyacetone phosphate (DHAP), a glycolysis intermediate, with ''sn''-glycerol-1-phosphate dehydrogenase. DHAP and thus glycerol 1-phosphate is also possible to be synthesized from amino acids and citric acid cycle intermediates via gluconeogenesis pathway. : + NAD(P)H + H+ → + NAD(P)+ Glycerol 1-phosphate is a starting material for ''de novo'' synthesis of ether lipids, such as those derived from archaeol and caldarchaeol. It is first geranylgeranylated on its ''sn''-3 position by a cytosolic enzyme, phosphoglycerol geranylgeranyltransferase. A second geranylgeranyl group is then added on the ''sn''-2 position making unsaturated archaetidic acid. Enantiomer Organisms other than archaea, i.e. bacteria and eucarya, use the enantiomer I ...
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Glycerol 2-phosphate
Glycerol 2-phosphate is the conjugate base of phosphoric ester of glycerol. It is commonly known as β-glycerophosphate or BGP. Unlike glycerol 1-phosphate and glycerol 3-phosphate, this isomer is not chiral. It is also less common. Applications β-Glycerophosphate is an inhibitor of the enzyme serine-threonine phosphatase. It is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. β-Glycerophosphate is also used to drive osteogenic differentiation of bone marrow stem cells ''in vitro''. β-Glycerophosphate is used to buffer M17 media for '' Lactococcus'' culture Culture () is an umbrella term which encompasses the social behavior, institutions, and norms found in human societies, as well as the knowledge, beliefs, arts, laws, customs, capabilities, and habits of the individuals in these groups ... in recombinant protein expression. Notes Organophosphates {{Biochem-stub ...
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