Glucose-1,6-bisphosphate

	Glucose-1,6-bisphosphate Glucose-1,6-bisphosphate is a derivative of glucose 1-phosphate. See also * Glucose-1,6-bisphosphate synthase * Glycogenesis Glycogenesis is the process of glycogen synthesis, in which glucose molecules are added to chains of glycogen for storage. This process is activated during rest periods following the Cori cycle, in the liver, and also activated by insulin in re ... {{organic-compound-stub Monosaccharide derivatives Organophosphates ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Glucose-1,6-bisphosphate Synthase Glucose-1,6-bisphosphate synthase is a type of enzyme called a phosphotransferase and is involved in mammalian starch and sucrose metabolism (KEGG2.7.1.106. It catalyzes the transfer of a phosphate group from 1,3-bisphosphoglycerate to glucose-1-phosphate, yielding 3-phosphoglycerate and glucose-1,6-bisphosphate. (image courtesy of the BRENDA enzyme database) The enzyme requires a divalent metal ion cofactor. Zinc (Zn2+), Magnesium (Mg2+), Manganese (Mn2+), Calcium (Ca2+), Nickel (Ni2+), Copper (Cu2+), Cadmium (Cd2+) are all proven effective cofactors ''in vitro''. Additionally, the enzyme appears to function optimally in a pH range from 7.3–8.7 and at a temperature of 25 °C. Metabolic significance of the catalyzed reaction The main product, glucose-1,6-bisphosphate, appears to have several functions: 1. Inhibition of hexokinase, an enzyme used in the first step of glycolysis. 2. Activation of phosphofructokinase-1 (PFK-1) and pyruvate kinase, both of which are en ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Glycogenesis Glycogenesis is the process of glycogen synthesis, in which glucose molecules are added to chains of glycogen for storage. This process is activated during rest periods following the Cori cycle, in the liver, and also activated by insulin in response to high glucose levels. Steps Glucose is converted into glucose 6-phosphate by the action of glucokinase or hexokinase with conversion of ATP to ADP. Glucose-6-phosphate is converted into glucose-1-phosphate by the action of phosphoglucomutase, passing through the obligatory intermediate glucose-1,6-bisphosphate. * Glucose-1-phosphate is converted into UDP-glucose by the action of the enzyme UDP-glucose pyrophosphorylase. Pyrophosphate is formed, which is later hydrolysed by pyrophosphatase into two phosphate molecules. * The enzyme glycogenin is needed to create initial short glycogen chains, which are then lengthened and branched by the other enzymes of glycogenesis. Glycogenin, a homodimer, has a tyrosine residue on each ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Glucose 1-phosphate Glucose 1-phosphate (also called cori ester) is a glucose molecule with a phosphate group on the 1'-carbon. It can exist in either the α- or β-anomeric form. Reactions of α-glucose 1-phosphate Catabolic In glycogenolysis, it is the direct product of the reaction in which glycogen phosphorylase cleaves off a molecule of glucose from a greater glycogen structure. A deficiency of muscle glycogen phosphorylase is known as glycogen storage disease type V (McArdle Disease). To be utilized in cellular catabolism it must first be converted to glucose 6-phosphate by the enzyme phosphoglucomutase in a free equilibrium. One reason that cells form glucose 1-phosphate instead of glucose during glycogen breakdown is that the very polar phosphorylated glucose cannot leave the cell membrane and so is marked for intracellular catabolism. Phosphoglucomutase-1 deficiency is known as glycogen storage disease type 14 (GSD XIV). Anabolic In glycogenesis, free glucose 1-phosphate can als ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Monosaccharide Derivatives Monosaccharides (from Greek '' monos'': single, '' sacchar'': sugar), also called simple sugars, are the simplest forms of sugar and the most basic units (monomers) from which all carbohydrates are built. They are usually colorless, water- soluble, and crystalline solids. Contrary to their name (sugars), only some monosaccharides have a sweet taste. Most monosaccharides have the formula (though not all molecules with this formula are monosaccharides). Examples of monosaccharides include glucose (dextrose), fructose (levulose), and galactose. Monosaccharides are the building blocks of disaccharides (such as sucrose and lactose) and polysaccharides (such as cellulose and starch). The table sugar used in everyday vernacular is itself a disaccharide sucrose comprising one molecule of each of the two monosaccharides D-glucose and D-fructose. Each carbon atom that supports a hydroxyl group is chiral, except those at the end of the chain. This gives rise to a number of isomeric ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]