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Furazabol
Furazabol (, ) (brand names Frazalon, Miotalon, Qu Zhi Shu), also known as androfurazanol, is a synthetic, orally active anabolic-androgenic steroid which has been marketed in Japan since 1969. It is a 17α-alkylated derivative of dihydrotestosterone (DHT) and is closely related structurally to stanozolol, differing from it only by having a furazan ring system instead of pyrazole. Furazabol has a relatively high ratio of anabolic to androgenic activity. As with other 17α-alkylated AAS, it may have a risk of hepatotoxicity. The drug has been described as an antihyperlipidemic and is claimed to be useful in the treatment of atherosclerosis and hypercholesterolemia, but according to William Llewellyn, such properties of furazabol are a myth. Doping Previously a relatively unknown drug to North American athletes, Furazabol gained notoriety in the Commission of Inquiry into the Use of Drugs and Banned Practices Intended to Increase Athletic Performance (known colloquially as the D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oral Administration
Oral administration is a route of administration where a substance is taken through the mouth. Per os abbreviated to P.O. is sometimes used as a direction for medication to be taken orally. Many medications are taken orally because they are intended to have a systemic effect, reaching different parts of the body via the bloodstream, for example. Oral administration can be easier and less painful than other routes, such as injection. However, the onset of action is relatively low, and the effectiveness is reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream. Some medications may cause gastrointestinal side effects, such as nausea or vomiting, when taken orally. Oral administration can also only be applied to conscious patients, and patients willing and able to swallow. Terminology ''Per os'' (; ''P.O.'') is an adverbial phrase meaning literally from Latin "through the mouth" or "by mouth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatotoxicity
Hepatotoxicity (from ''hepatic toxicity'') implies chemical-driven liver damage. Drug-induced liver injury is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in overdoses (e.g. paracetamol) and sometimes even when introduced within therapeutic ranges (e.g. halothane), may injure the organ. Other chemical agents, such as those used in laboratories and industries, natural chemicals (e.g., microcystins), and herbal remedies (two prominent examples being kava, mechanism unknown, and comfrey, through its pyrrolizidine alkaloid content) can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins. More than 900 drugs have been implicated in causing liver injury (see LiverTox, exter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatotoxins
Hepatotoxicity (from ''hepatic toxicity'') implies chemical-driven liver damage. Drug-induced liver injury is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in overdoses (e.g. paracetamol) and sometimes even when introduced within therapeutic ranges (e.g. halothane), may injure the organ. Other chemical agents, such as those used in laboratories and industries, natural chemicals (e.g., microcystins), and herbal remedies (two prominent examples being kava, mechanism unknown, and comfrey, through its pyrrolizidine alkaloid content) can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins. More than 900 drugs have been implicated in causing liver injury (see LiverTox, externa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Androstanes
An androgen (from Greek ''andr-'', the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This includes the embryological development of the primary male sex organs, and the development of male secondary sex characteristics at puberty. Androgens are synthesized in the testes, the ovaries, and the adrenal glands. Androgens increase in both males and females during puberty. The major androgen in males is testosterone. Dihydrotestosterone (DHT) and androstenedione are of equal importance in male development. DHT ''in utero'' causes differentiation of the penis, scrotum and prostate. In adulthood, DHT contributes to balding, prostate growth, and sebaceous gland activity. Although androgens are commonly thought of only as male sex hormones, females also have them, but at lower levels: they function in libido and sexual arousal. Also, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Androgens And Anabolic Steroids
An androgen (from Greek ''andr-'', the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This includes the embryological development of the primary male sex organs, and the development of male secondary sex characteristics at puberty. Androgens are synthesized in the testes, the ovaries, and the adrenal glands. Androgens increase in both males and females during puberty. The major androgen in males is testosterone. Dihydrotestosterone (DHT) and androstenedione are of equal importance in male development. DHT ''in utero'' causes differentiation of the penis, scrotum and prostate. In adulthood, DHT contributes to balding, prostate growth, and sebaceous gland activity. Although androgens are commonly thought of only as male sex hormones, females also have them, but at lower levels: they function in libido and sexual arousal. Also, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tertiary Alcohols
In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl () functional group bound to a saturated carbon atom. The term ''alcohol'' originally referred to the primary alcohol ethanol (ethyl alcohol), which is used as a drug and is the main alcohol present in alcoholic drinks. An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula . Simple monoalcohols that are the subject of this article include primary (), secondary () and tertiary () alcohols. The suffix ''-ol'' appears in the IUPAC chemical name of all substances where the hydroxyl group is the functional group with the highest priority. When a higher priority group is present in the compound, the prefix ''hydroxy-'' is used in its IUPAC name. The suffix ''-ol'' in non-IUPAC names (such as paracetamol or cholesterol) also typically indicates that the substance is an alcohol. However, some compound ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angella Taylor-Issajenko
Angella Taylor-Issajenko, CM (née Taylor; born September 28, 1958) is a Canadian coach and former sprinter. She won an Olympic silver medal in the 4 × 100 metres relay in Los Angeles 1984. At the Commonwealth Games she won seven medals, including the 100 metres title in Brisbane 1982 and the 200 metres in Edinburgh 1986. Career Angella was born in Jamaica on September 28, 1958. Her breakout performance came at the 1979 Pan Am Games, where she took a bronze in the 100 m and a silver in the 200 m, and set national records of 11.20 and 22.80 respectively. Despite Canada's boycott of the 1980 Olympic Games in Moscow, she dominated post-Olympic competition in the summer of 1980, winning several meets, and finishing second in the 100 m to Marlies Göhr, and third in the 200 m behind Bärbel Wöckel at the final stop in Zurich. She was the 200 m champion at the Liberty Bell Classic (which was an alternate to the boycotted Olympics). She lowered her national records to 11.12 for t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Astaphan
George Mario "Jamie" Sahely Chehin Astaphan, M.D., B.Sc. (May 22, 1946 – August 18, 2006) was a physician who became infamous for giving steroids to the sprinter Ben Johnson. Dr. Astaphan was born on the island of St. Kitts in the West Indies. He attended universities in Canada, where he received a BSc degree from Sir George Williams University (1967) in Montreal, and then graduated from the University of Toronto's Faculty of Medicine in 1971. He practiced medicine in various places in Ontario, Canada: Warkworth, Campbellford, Scarborough, North York, and Toronto. In 1988 he was accused of administering the stanozolol which led Ben Johnson to lose his 100m Gold Medal. These allegations were never proven and Dr. Astaphan denied them for the next 18 years. As a result of the Dubin Inquiry, he was fined by the Ontario College of Physicians and Surgeons in June 1991 and banned from practicing medicine in the province for 18 months. In 1994, after the plane he was flying on was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stanozolol
Stanozolol (Abbreviation, abbrev. Stz), sold under many brand names, is an androgen and anabolic steroid (AAS) medication derived from dihydrotestosterone (DHT). It is used to treat hereditary angioedema. It was developed by American pharmaceutical company Sterling Drug, Winthrop Laboratories (Sterling Drug) in 1962, and has been approved by the U.S. Food and Drug Administration for human use, though it is no longer marketed in the USA. It is also used in veterinary medicine. Stanozolol has mostly been discontinued, and remains available in only a few countries. It is given Oral administration, by mouth in humans or by Intramuscular injection, injection into muscle in animals. Unlike most injectable AAS, stanozolol is not esterified and is sold as an Aqueous solution, aqueous suspension, or in oral tablet form. The drug has a high oral bioavailability, due to a C17α alkylation which allows the hormone to survive first-pass liver metabolism when ingested. It is because of this th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ben Johnson (Canadian Sprinter)
Benjamin Sinclair Johnson, (born December 30, 1961) is a Canadian former sprinter. During the 1987–88 season he held the title of the world's fastest man, breaking both the 100m and the 60m indoor World Records. He won gold medals in the 100 metres at the 1987 World Championships and 1988 Summer Olympics, before he was disqualified for doping and stripped of his medals. He was the first man who beat 9.9 (Rome, 1987) and 9.8 seconds (Seoul, 1988). He won two bronze medals at the 1984 Summer Olympics, as well as gold medals at the 1985 World Indoor Championships, 1986 Goodwill Games and 1986 Commonwealth Games. He was trained by Charlie Francis, he called it a father-son relationship. Biography Career background Benjamin Johnson was born in Falmouth, Jamaica, and emigrated to Canada in 1976, residing in the Toronto suburb of Scarborough, Ontario. Johnson met coach Charlie Francis and joined the Scarborough Optimists track and field club, training at York University. Fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dubin Inquiry
The Dubin inquiry was a Canadian government Commission of Inquiry into the Use of Drugs and Banned Practices Intended to Increase Athletic Performance held in 1989 after the Ben Johnson doping scandal at the 1988 Seoul Olympics. The commission was given to Ontario Court of Appeal Chief Justice Charles Dubin. He released his report in June 1990.Cyr, Alex, "The Silver Lining Of Sin: How Ben Johnson And The Dubin Inquiry Resonates With Canadian Olympians Since 1988" (2019). University of Windsor, #7804: https://scholar.uwindsor.ca/etd/7804 Dubin wrote that doping "threatened the essential integrity of sport and is destructive of its very objectives", when he issued more than 70 recommendations. Dubin concluded that "the failure of many sport governing bodies to treat the problem more seriously and to take more effective means to detect and deter the use of such drugs has contributed in large measure to the extensive use of drugs in athletes." Dubin said that there was a "moral crisis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Commission Of Inquiry Into The Use Of Drugs And Banned Practices Intended To Increase Athletic Performance
The Dubin inquiry was a Canadian government Commission of Inquiry into the Use of Drugs and Banned Practices Intended to Increase Athletic Performance held in 1989 after the Ben Johnson doping scandal at the 1988 Seoul Olympics. The commission was given to Ontario Court of Appeal Chief Justice Charles Dubin. He released his report in June 1990.Cyr, Alex, "The Silver Lining Of Sin: How Ben Johnson And The Dubin Inquiry Resonates With Canadian Olympians Since 1988" (2019). University of Windsor, #7804: https://scholar.uwindsor.ca/etd/7804 Dubin wrote that doping "threatened the essential integrity of sport and is destructive of its very objectives", when he issued more than 70 recommendations. Dubin concluded that "the failure of many sport governing bodies to treat the problem more seriously and to take more effective means to detect and deter the use of such drugs has contributed in large measure to the extensive use of drugs in athletes." Dubin said that there was a "moral crisis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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