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Fumigaclavine C
Fumigaclavine C is an ergoline alkaloid produced by ''Aspergillus fumigatus ''Aspergillus fumigatus'' is a species of fungus in the genus ''Aspergillus'', and is one of the most common ''Aspergillus'' species to cause disease in individuals with an immunodeficiency. ''Aspergillus fumigatus'', a saprotroph widespread in ...''. Both 8α and 8β diastereomers (epimers) were named fumigaclavine C in scientific literature. See also * 9-Deacetoxyfumigaclavine C * Fumigaclavine A * Fumigaclavine B * Fumigaclavine A dimethylallyltransferase * Desformylflustrabromine References Ergolines Acetate esters {{alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ergoline
Ergoline is a chemical compound whose structural skeleton is contained in a variety of alkaloids, referred to as ergoline derivatives or ergoline alkaloids. Ergoline alkaloids, one being ergine, were initially characterized in ergot. Some of these are implicated in the condition ergotism, which can take a convulsive form or a gangrenous form. Even so, many ergoline alkaloids have been found to be clinically useful. Annual world production of ergot alkaloids has been estimated at 5,000–8,000 kg of all ergopeptines and 10,000–15,000 kg of lysergic acid, used primarily in the manufacture of semi-synthetic derivatives. Others, such as lysergic acid diethylamide, better known as LSD, a semi-synthetic derivative, and ergine, a natural derivative found in ''Argyreia nervosa'', ''Ipomoea tricolor'' and related species, are known psychedelic substances. Natural occurrence Ergoline alkaloids are found in lower fungi and some species of flowering plants: the Mexican species ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aspergillus Fumigatus
''Aspergillus fumigatus'' is a species of fungus in the genus ''Aspergillus'', and is one of the most common ''Aspergillus'' species to cause disease in individuals with an immunodeficiency. ''Aspergillus fumigatus'', a saprotroph widespread in nature, is typically found in soil and decaying organic matter, such as compost heaps, where it plays an essential role in carbon and nitrogen recycling. Colonies of the fungus produce from conidiophores; thousands of minute grey-green conidia (2–3 μm) which readily become airborne. For many years, ''A. fumigatus'' was thought to only reproduce asexually, as neither mating nor meiosis had ever been observed. In 2008, ''A. fumigatus'' was shown to possess a fully functional sexual reproductive cycle, 145 years after its original description by Fresenius. Although ''A. fumigatus'' occurs in areas with widely different climates and environments, it displays low genetic variation and a lack of population genetic differentiation on a globa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
9-Deacetoxyfumigaclavine C
9-Deacetoxyfumigaclavine C is an ergoline alkaloid. It is a potent, selective, anticancer compound, with ''in vitro'' activity comparable to doxorubicin (IC50 = 3.1 μM against K562). 9-Deacetoxyfumigaclavine C is a compound made by a variety of fungi A fungus ( : fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, separately from .... References Ergolines {{Alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fumigaclavine A
Fumigaclavine A is an antibacterial ergoline alkaloid produced by endophytic '' Aspergillus''. Both 8α and 8β diastereomers (epimers) were named fumigaclavine A in scientific literature. See also * Fumigaclavine B * Fumigaclavine C Fumigaclavine C is an ergoline alkaloid produced by ''Aspergillus fumigatus ''Aspergillus fumigatus'' is a species of fungus in the genus ''Aspergillus'', and is one of the most common ''Aspergillus'' species to cause disease in individuals wit ... * Fumigaclavine A dimethylallyltransferase References Ergolines Acetate esters {{alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fumigaclavine B
Fumigaclavine B is an ergoline compound made by certain fungi. Both 8α and 8β diastereomers (epimers) were named fumigaclavine B in scientific literature. See also * Fumigaclavine A * Fumigaclavine C Fumigaclavine C is an ergoline alkaloid produced by ''Aspergillus fumigatus ''Aspergillus fumigatus'' is a species of fungus in the genus ''Aspergillus'', and is one of the most common ''Aspergillus'' species to cause disease in individuals wit ... * Fumigaclavine B O-acetyltransferase References * https://pubchem.ncbi.nlm.nih.gov/compound/46173120#section=Top Ergolines {{alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fumigaclavine A Dimethylallyltransferase
Fumigaclavine A dimethylallyltransferase (, ''FgaPT1'') is an enzyme with systematic name ''dimethylallyl-diphosphate:fumigaclavine A dimethylallyltransferase''. This enzyme catalyses the following chemical reaction : fumigaclavine A + dimethylallyl diphosphate \rightleftharpoons fumigaclavine C + diphosphate Fumigaclavine C is an ergot alkaloid produced by some fungi A fungus ( : fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, separately from ... of the '' Trichocomaceae'' family. References External links * {{Portal bar, Biology, border=no EC 2.5.1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Desformylflustrabromine
Desformylflustrabromine (dFBr) is a monomethyltryptamine derivative which was first isolated as a secondary metabolite of the marine bryozoan '' Flustra foliacea''. Bioactivity dFBr has been identified as a novel positive allosteric modulator of neuronal nicotinic acetylcholine receptor with sub-type specificity for heteromeric receptor with no effect on homomeric sub-type. A recent study has been published which describes the synthesis of water-soluble salts of dFBr and its action has been confirmed as selective potentiator of α4β2 nicotinic acetylcholine receptor responses by using two-electrode voltage clamp whole cell recordings. In the year 2002 it was reported that dFBr was cytotoxic on human colon cancer cell line HCT 116. Desformylflustrabromine has also been found to be a positive allosteric modulator for the α2β2 subtype of neuronal nicotinic acetylcholine receptor. Additionally it relieves the inhibition of both α2β2 and α4β2 nicotinic acetylcholine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ergolines
Ergoline is a chemical compound whose structural skeleton is contained in a variety of alkaloids, referred to as ergoline derivatives or ergoline alkaloids. Ergoline alkaloids, one being ergine, were initially characterized in ergot. Some of these are implicated in the condition ergotism, which can take a convulsive form or a gangrenous form. Even so, many ergoline alkaloids have been found to be clinically useful. Annual world production of ergot alkaloids has been estimated at 5,000–8,000 kg of all ergopeptines and 10,000–15,000 kg of lysergic acid, used primarily in the manufacture of semi-synthetic derivatives. Others, such as lysergic acid diethylamide, better known as LSD, a semi-synthetic derivative, and ergine, a natural derivative found in ''Argyreia nervosa'', ''Ipomoea tricolor'' and related species, are known psychedelic substances. Natural occurrence Ergoline alkaloids are found in lower fungi and some species of flowering plants: the Mexican species ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
