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Epidermal Differentiation Complex
The epidermal differentiation complex (EDC) is a gene complex comprising over fifty genes encoding proteins involved in the terminal differentiation and cornification of keratinocytes, the primary cell type of the epidermis. In humans, the complex is located on a 1.9 Mbp stretch within chromosome 1q21. The proteins encoded by EDC genes are closely related in terms of function, and evolutionarily they belong to three distinct gene families: the cornified envelope precursor family, the S100 protein family and the S100 fused type protein (SFTP) family. It has been hypothesized that the clustering of EDC genes occurred due to duplication events which were evolutionarily favored during the adaptation to terrestrial environments. EDC proteins have been involved in a variety of skin disorders including ichthyosis vulgaris, atopic dermatitis and psoriasis. History The epidermal differentiation complex was first described in 1993, and further characterized in 1996, when Dietmar Mischke an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Complex
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gene– ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SPRR1B
Cornifin-B is a protein that in humans is encoded by the ''SPRR1B'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... References Further reading * * * * * * * * * * * * * * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SPRR3
Small proline-rich protein 3 is a protein that in humans is encoded by the ''SPRR3'' gene, which is found within the epidermal differentiation complex The epidermal differentiation complex (EDC) is a gene complex comprising over fifty genes encoding proteins involved in the terminal differentiation and cornification of keratinocytes, the primary cell type of the epidermis. In humans, the complex ... (EDC). References Further reading * * * * * * * * * * * * * * * * * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SPRR2G
The Southern Pacific (or Espee from the railroad initials- SP) was an American Class I railroad network that existed from 1865 to 1996 and operated largely in the Western United States. The system was operated by various companies under the names Southern Pacific Railroad, Southern Pacific Company and Southern Pacific Transportation Company. The original Southern Pacific began in 1865 as a land holding company. The last incarnation of the Southern Pacific, the Southern Pacific Transportation Company, was founded in 1969 and assumed control of the Southern Pacific system. The Southern Pacific Transportation Company was acquired in 1996 by the Union Pacific Corporation and merged with their Union Pacific Railroad. The Southern Pacific legacy founded hospitals in San Francisco, Tucson, and Houston. In the 1970s, it also founded a telecommunications network with a state-of-the-art microwave and fiber optic backbone. This telecommunications network became part of Sprint, a compan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SPRR2F
The Southern Pacific (or Espee from the railroad initials- SP) was an American Class I railroad network that existed from 1865 to 1996 and operated largely in the Western United States. The system was operated by various companies under the names Southern Pacific Railroad, Southern Pacific Company and Southern Pacific Transportation Company. The original Southern Pacific began in 1865 as a land holding company. The last incarnation of the Southern Pacific, the Southern Pacific Transportation Company, was founded in 1969 and assumed control of the Southern Pacific system. The Southern Pacific Transportation Company was acquired in 1996 by the Union Pacific Corporation and merged with their Union Pacific Railroad. The Southern Pacific legacy founded hospitals in San Francisco, Tucson, and Houston. In the 1970s, it also founded a telecommunications network with a state-of-the-art microwave and fiber optic backbone. This telecommunications network became part of Sprint, a compan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SPRR2E
The Southern Pacific (or Espee from the railroad initials- SP) was an American Class I railroad network that existed from 1865 to 1996 and operated largely in the Western United States. The system was operated by various companies under the names Southern Pacific Railroad, Southern Pacific Company and Southern Pacific Transportation Company. The original Southern Pacific began in 1865 as a land holding company. The last incarnation of the Southern Pacific, the Southern Pacific Transportation Company, was founded in 1969 and assumed control of the Southern Pacific system. The Southern Pacific Transportation Company was acquired in 1996 by the Union Pacific Corporation and merged with their Union Pacific Railroad. The Southern Pacific legacy founded hospitals in San Francisco, Tucson, and Houston. In the 1970s, it also founded a telecommunications network with a state-of-the-art microwave and fiber optic backbone. This telecommunications network became part of Sprint, a compan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SPRR2D
The Southern Pacific (or Espee from the railroad initials- SP) was an American Class I railroad network that existed from 1865 to 1996 and operated largely in the Western United States. The system was operated by various companies under the names Southern Pacific Railroad, Southern Pacific Company and Southern Pacific Transportation Company. The original Southern Pacific began in 1865 as a land holding company. The last incarnation of the Southern Pacific, the Southern Pacific Transportation Company, was founded in 1969 and assumed control of the Southern Pacific system. The Southern Pacific Transportation Company was acquired in 1996 by the Union Pacific Corporation and merged with their Union Pacific Railroad. The Southern Pacific legacy founded hospitals in San Francisco, Tucson, and Houston. In the 1970s, it also founded a telecommunications network with a state-of-the-art microwave and fiber optic backbone. This telecommunications network became part of Sprint, a compan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
