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EIF-2
Eukaryotic Initiation Factor 2 (eIF2) is an eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNAiMet to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer consisting of an alpha (also called subunit 1, EIF2S1), a beta (subunit 2, EIF2S2), and a gamma (subunit 3, EIF2S3) subunit. Once the initiation phase has completed, eIF2 is released from the ribosome bound to GDP as an inactive binary complex. To participate in another round of translation initiation, this GDP must be exchanged for GTP. Function eIF2 is an essential factor for protein synthesis that forms a ternary complex (TC) with GTP and the initiator Met-tRNAiMet. After its formation, the TC binds the 40S ribosomal subunit to form the 43S preinitiation complex (43S PIC). 43S PIC assembly is believed to be stimulated by the initiation factors eIF1, eIF1A, and the eIF3 complex according to ''in vitro'' experiments. The 43S PIC then ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EIF2S1
Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the ''EIF2S1'' gene. Function The protein encoded by this gene is the alpha (α) subunit of the translation initiation factor eIF2 protein complex which catalyzes an early regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA (Met-tRNAiMet) to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (α, 36 kD, this article), beta (β, 38 kD), and gamma (γ, 52 kD). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2α. Phosphorylation of eIF2α by EIF-2 kinases plays a key role in regulating the integrated stress response. Clinical significance After reperfusion following brain ischemia, there is inhibition of neuron protein synthesis due to phosphorylation of eIF2α. There is colocalization between phos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eukaryotic Initiation Factor
Eukaryotic initiation factors (eIFs) are Protein, proteins or Protein complex, protein complexes involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of ribosomal preinitiation complexes around the start codon and are an important input for Post-transcriptional regulation, post-transcription gene regulation. Several initiation factors form a complex with the small 40S ribosomal subunit and Met-tRNAiMet called the 43S preinitiation complex (43S PIC). Additional factors of the eIF4F complex (eIF4A, E, and G) recruit the 43S PIC to the five-prime cap structure of the mRNA, from which the 43S particle scans 5'-->3' along the mRNA to reach an AUG start codon. Recognition of the start codon by the Met-tRNAiMet promotes gated phosphate and eIF1 release to form the 48S preinitiation complex (48S PIC), followed by large 60S ribosomal subunit recruitment to form the Eukaryotic ribosome (80S), 80S ribosome. There exist many more eukaryotic ini ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EIF4F
Eukaryotic initiation factor 4F (eIF4F) is a heterotrimeric protein complex that binds the 5' cap of messenger RNAs (mRNAs) to promote eukaryotic translation initiation. The eIF4F complex is composed of three non-identical subunits: the DEAD-box RNA helicase eIF4A, the cap-binding protein eIF4E, and the large "scaffold" protein eIF4G. The mammalian eIF4F complex was first described in 1983, and has been a major area of study into the molecular mechanisms of cap-dependent translation initiation ever since. Function eIF4F is important for recruiting the small ribosomal subunit (40S) to the 5' cap of mRNAs during cap-dependent translation initiation. Components of the complex are also involved in cap-independent translation initiation; for instance, certain viral proteases cleave eIF4G to remove the eIF4E-binding region, thus inhibiting cap-dependent translation. Structure Structures of eIF4F components have been solved individually and as partial complexes by a variety ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homo Sapiens
Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, and language. Humans are highly social and tend to live in complex social structures composed of many cooperating and competing groups, from families and kinship networks to political states. Social interactions between humans have established a wide variety of values, social norms, and rituals, which bolster human society. Its intelligence and its desire to understand and influence the environment and to explain and manipulate phenomena have motivated humanity's development of science, philosophy, mythology, religion, and other fields of study. Although some scientists equate the term ''humans'' with all members of the genus ''Homo'', in common usage, it generally refers to ''Homo sapiens'', the only extant member. Anatomically mod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dalton (unit)
The dalton or unified atomic mass unit (symbols: Da or u) is a non-SI unit of mass widely used in physics and chemistry. It is defined as of the mass of an unbound neutral atom of carbon-12 in its nuclear and electronic ground state and at rest. The atomic mass constant, denoted ''m''u, is defined identically, giving . This unit is commonly used in physics and chemistry to express the mass of atomic-scale objects, such as atoms, molecules, and elementary particles, both for discrete instances and multiple types of ensemble averages. For example, an atom of helium-4 has a mass of . This is an intrinsic property of the isotope and all helium-4 atoms have the same mass. Acetylsalicylic acid (aspirin), , has an average mass of approximately . However, there are no acetylsalicylic acid molecules with this mass. The two most common masses of individual acetylsalicylic acid molecules are , having the most common isotopes, and , in which one carbon is carbon-13. The molecular mass ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annu
Heliopolis (I͗wnw, Iunu or 𓉺𓏌𓊖; egy, I͗wnw, 'the Pillars'; cop, ⲱⲛ; gr, Ἡλιούπολις, Hēlioúpοlis, City of the Sun) was a major city of ancient Egypt. It was the capital of the 13th or Heliopolite Nome of Lower Egypt and a major religious centre. It is now located in Ayn Shams, a northeastern suburb of Cairo. Heliopolis was one of the oldest cities of ancient Egypt, occupied since the Predynastic Period.. It greatly expanded under the Old and Middle Kingdoms but is today mostly destroyed, its temples and other buildings having been scavenged for the construction of medieval Cairo. Most information about the ancient city comes from surviving records. The major surviving remnant of Heliopolis is the obelisk of the Temple of Ra-Atum erected by Senusret I of Dynasty XII. It still stands in its original position, now within Al-Masalla in Al-Matariyyah, Cairo. The high red granite obelisk weighs 120 tons (240,000 lbs) and is believed to be the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EIF2B5
Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the ''EIF2B5'' gene. Interactions EIF2B5 has been shown to interact with EIF2B2 and EIF2B1 Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the ''EIF2B1'' gene. Interactions EIF2B1 has been shown to interact Advocates for Informed Choice, doing business as, dba interACT or interACT Advo .... References Further reading * * * * * * * * * * * * * * * * {{gene-3-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EIF2B4
Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the ''EIF2B4'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... References Further reading * * * * * * * * * * * * * * * * * * {{gene-2-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EIF2B3
Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the ''EIF2B3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... References Further reading * * * * * * * * * * * * * * * * * * * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EIF2B2
Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the ''EIF2B2'' gene. Function Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP. Interactions EIF2B2 has been shown to interact with EIF2B5 and NCK1 Cytoplasmic protein NCK1 is a protein that in humans is encoded by the ''NCK1'' gene. Gene The Nck (non-catalytic region of tyrosine kinase adaptor protein 1) belongs to the adaptor family of proteins. The nck gene was initially isolated from .... References Further reading * * * * * * * * * * * * * * * * * {{gene-14-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EIF2B1
Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the ''EIF2B1'' gene. Interactions EIF2B1 has been shown to interact with EIF2B5 Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the ''EIF2B5'' gene. Interactions EIF2B5 has been shown to interact with EIF2B2 and EIF2B1 Translation initiation factor eIF-2B subunit alpha is a .... References Further reading * * * * * * * * * * * * * * * * * {{gene-12-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EIF2B
eIF2B is a protein complex found in eukaryotes. It is the guanine nucleotide exchange factor for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2-GDP to the active eIF2- GTP. This activation is hindered by phosphorylation of the alpha subunit of eIF2, which leads to a stable eIF2α-P-GDP-eIF2B complex and therefore inhibits translation initiation. Human genes which encode eIF-2B proteins include: * EIF2B1 – alpha subunit (26kDa) * EIF2B2 – beta subunit (39kDa) * EIF2B3 – gamma subunit (58kDa) * EIF2B4 – delta subunit (67kDa) * EIF2B5 Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the ''EIF2B5'' gene. Interactions EIF2B5 has been shown to interact with EIF2B2 and EIF2B1 Translation initiation factor eIF-2B subunit alpha is a ... – epsilon subunit (82kDa) References Protein biosynthesis Gene expression Proteins {{enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
