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Endomicroscopy
Endomicroscopy is a technique for obtaining histology-like images from inside the human body in real-time,Jabbour, J.M., et al., Confocal Endomicroscopy: Instrumentation and Medical Applications. Annals of biomedical engineering, 2011. a process known as ‘optical biopsy’.Sonn, G.a., et al., Optical biopsy of human bladder neoplasia with in vivo confocal laser endomicroscopy. The Journal of urology, 2009. 182: p. 1299-305. It generally refers to fluorescence confocal microscopy, although multi-photon microscopy and optical coherence tomography have also been adapted for endoscopic use.Jung, J.C., et al., In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy. Journal of neurophysiology, 2004. 92: p. 3121-33.Myaing, M.T., et al., Fiber-optic scanning two-photon fluorescence endoscope. Optics Letetrs, 2006. 31: p. 1076-78. Commercially available clinical and pre-clinical endomicroscopes can achieve a resolution on the order of a micrometre, have a fie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mauna Kea Technologies
Mauna Kea Technologies is a global medical device company focused on endomicroscopy, the field of microscopic imaging during endoscopy procedures. The company researches, develops and markets tools to visualize, detect, and rule out abnormalities including malignant and pre-malignant tumors or lesions in the gastrointestinal and pulmonary tracts. The company makes Cellvizio, a probe-based Confocal Laser Endomicroscopy (pCLE) system, which provides physicians and researchers with real-time access to histological information during standard endoscopy procedures through high-resolution cellular imaging of internal tissues. Cellvizio is used in medical applications such as gastrointestinal endoscopy, pulmonology and urology to help physicians diagnose lesions and make accurate treatment decisions in real-time. Cellvizio went public in July 2011 and trades on the NYSE Euronext exchange. Cellvizio Technology Cellvizio technology generates cellular images using a small, flexible micros ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Confocal Microscopy
Confocal microscopy, most frequently confocal laser scanning microscopy (CLSM) or laser confocal scanning microscopy (LCSM), is an optical imaging technique for increasing optical resolution and contrast of a micrograph by means of using a spatial pinhole to block out-of-focus light in image formation. Capturing multiple two-dimensional images at different depths in a sample enables the reconstruction of three-dimensional structures (a process known as optical sectioning) within an object. This technique is used extensively in the scientific and industrial communities and typical applications are in life sciences, semiconductor inspection and materials science. Light travels through the sample under a conventional microscope as far into the specimen as it can penetrate, while a confocal microscope only focuses a smaller beam of light at one narrow depth level at a time. The CLSM achieves a controlled and highly limited depth of field. Basic concept The principle of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Esophagus Intestinal Metaplasia
The esophagus (American English) or oesophagus (British English; both ), non-technically known also as the food pipe or gullet, is an organ in vertebrates through which food passes, aided by peristaltic contractions, from the pharynx to the stomach. The esophagus is a fibromuscular tube, about long in adults, that travels behind the trachea and heart, passes through the diaphragm, and empties into the uppermost region of the stomach. During swallowing, the epiglottis tilts backwards to prevent food from going down the larynx and lungs. The word ''oesophagus'' is from Ancient Greek οἰσοφάγος (oisophágos), from οἴσω (oísō), future form of φέρω (phérō, “I carry”) + ἔφαγον (éphagon, “I ate”). The wall of the esophagus from the lumen outwards consists of mucosa, submucosa (connective tissue), layers of muscle fibers between layers of fibrous tissue, and an outer layer of connective tissue. The mucosa is a stratified squamous epith ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dispersion (optics)
In optics, and by analogy other branches of physics dealing with wave propagation, dispersion is the phenomenon in which the phase velocity of a wave depends on its frequency; sometimes the term chromatic dispersion is used for specificity to optics in particular. A medium having this common property may be termed a dispersive medium (plural ''dispersive media''). Although the term is used in the field of optics to describe light and other electromagnetic waves, dispersion in the same sense can apply to any sort of wave motion such as acoustic dispersion in the case of sound and seismic waves, and in gravity waves (ocean waves). Within optics, dispersion is a property of telecommunication signals along transmission lines (such as microwaves in coaxial cable) or the pulses of light in optical fiber. Physically, dispersion translates in a loss of kinetic energy through absorption. In optics, one important and familiar consequence of dispersion is the change in the angle of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fluorescein
Fluorescein is an organic compound and dye based on the xanthene tricyclic structural motif, formally belonging to triarylmethine dyes family. It is available as a dark orange/red powder slightly soluble in water and alcohol. It is widely used as a fluorescent tracer for many applications. The color of its aqueous solutions is green by reflection and orange by transmission (its spectral properties are dependent on pH of the solution), as can be noticed in bubble levels, for example, in which fluorescein is added as a colorant to the alcohol filling the tube in order to increase the visibility of the air bubble contained within (thus enhancing the precision of the instrument). More concentrated solutions of fluorescein can even appear red (because under these conditions nearly all incident emission is re-absorbed by the solution). It is on the World Health Organization's List of Essential Medicines. Uses Fluorescein sodium, the sodium salt of fluorescein, is used extensivel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acriflavinium Chloride
Acriflavine (INN: acriflavinium chloride) is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. It is a dye and it stains the skin and may irritate. The hydrochloride form is more irritating than the neutral form. It is derived from acridine. Commercial preparations are often mixtures with proflavine. It is known by a variety of commercial names. Uses Medical use Acriflavine was developed in 1912 by Paul Ehrlich, a German medical researcher, and was used during the First World War against sleeping sickness and as a topical antiseptic. Other uses Acriflavine is used in biochemistry for fluorescently labeling high molecular weight RNA. It is used as treatment for external fungal infections of aquarium fish. Research In an animal model, acriflavine has been shown to inhibit HIF-1, which prevents blood vessels growing to supply tumors with blood and interferes with glucose uptake and use. Acriflavine might be effectiv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hoya Corporation
is a Japanese company manufacturing optical products such as photomasks, photomask blanks and hard disk drive platters, contact lenses and eyeglass lenses for the health-care market, medical photonics, lasers, photographic filters, medical flexible endoscopy equipment, and software. Hoya Corporation is one of the Forbes Global 2000 Leading Companies and Industry Week 1000 Company. History of Hoya-Pentax merger Hoya discussed a merger with Pentax into Hoya Pentax HD Corporation during 2007. Hoya's primary goal was to strengthen its medical-related business by taking advantage of Pentax's technologies and expertise in the field of endoscopes, intraocular lenses, surgical loupes, biocompatible ceramics, etc. It was speculated that Pentax's camera business could be sold off after the merger. The merger was initially intended to be completed by October 1, 2007. However, Pentax management decided to not pursue the originally planned share swap, and other options for a merger were dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pentax
is a brand name used primarily by the Japanese multinational imaging and electronics company Ricoh for DSLR cameras, lenses, sport optics (including binoculars and rifle scopes), and CCTV optics. The Pentax brand is also used by Hoya Corporation for medical products & services, TI Asahi for surveying instruments, and Seiko Optical Products for certain optical lenses. Corporate history Early history The company was founded as Asahi Kogaku Goshi Kaisha in November 1919 by Kumao Kajiwara, at a shop in the Toshima suburb of Tokyo, and began producing spectacle lenses (which it still manufactures). In 1938 it changed its name to , and by this time it was also manufacturing camera/cine lenses. In the lead-up to World War II, Asahi Optical devoted much of its time to fulfilling military contracts for optical instruments. At the end of the war, Asahi Optical was disbanded by the occupying powers, being allowed to re-form in 1948. The company resumed its pre-war activities, manufactur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carl Zeiss Meditec
Carl Zeiss Meditec AG is a multinational medical technology company and subsidiary of Carl Zeiss AG. It manufactures tools for eye examinations and medical lasers as well as solutions for neurosurgery, dentistry, gynecology and oncology. Among its products are the most common tools used by ophthalmologists and optometrists. In October 2018, Carl Zeiss Meditec won FDA premarket approval for its ReLEx Smile laser system. Also in October 2018, Carl Zeiss Meditec announced the acquisition of Reno, Nevada Nevada ( ; ) is a U.S. state, state in the Western United States, Western region of the United States. It is bordered by Oregon to the northwest, Idaho to the northeast, California to the west, Arizona to the southeast, and Utah to the east. N ...-based IanTech for an undisclosed sum. In September 2019, Carl Zeiss Meditec launched the CIRRUS 6000 at the European Society of Retina Specialists 2019 Congress. References External links * Manufacturing companies of Ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endoscopy
An endoscopy is a procedure used in medicine to look inside the body. The endoscopy procedure uses an endoscope to examine the interior of a hollow organ or cavity of the body. Unlike many other medical imaging techniques, endoscopes are inserted directly into the organ. There are many types of endoscopies. Depending on the site in the body and type of procedure, an endoscopy may be performed by either a doctor or a surgeon. A patient may be fully conscious or anaesthetised during the procedure. Most often, the term ''endoscopy'' is used to refer to an examination of the upper part of the gastrointestinal tract, known as an esophagogastroduodenoscopy. For nonmedical use, similar instruments are called borescopes. History Adolf Kussmaul was fascinated by sword swallowers who would insert a sword down their throat without gagging. This drew inspiration to insert a camera, the next problem to solve was how to insert a source of light, as they were still relying on candles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microelectromechanical Systems
Microelectromechanical systems (MEMS), also written as micro-electro-mechanical systems (or microelectronic and microelectromechanical systems) and the related micromechatronics and microsystems constitute the technology of microscopic devices, particularly those with moving parts. They merge at the nanoscale into nanoelectromechanical systems (NEMS) and nanotechnology. MEMS are also referred to as micromachines in Japan and microsystem technology (MST) in Europe. MEMS are made up of components between 1 and 100 micrometers in size (i.e., 0.001 to 0.1 mm), and MEMS devices generally range in size from 20 micrometres to a millimetre (i.e., 0.02 to 1.0 mm), although components arranged in arrays (e.g., digital micromirror devices) can be more than 1000 mm2. They usually consist of a central unit that processes data (an integrated circuit chip such as microprocessor) and several components that interact with the surroundings (such as microsensors). Because of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
