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Dorsomedial Prefrontal Cortex
The dorsomedial prefrontal cortex (dmPFC or DMPFC is a section of the prefrontal cortex in some species' brain anatomy. It includes portions of Brodmann areas BA8, BA9, BA10, BA24 and BA32, although some authors identify it specifically with BA8 and BA9 Some notable sub-components include the dorsal anterior cingulate cortex (BA24 and BA32), the prelimbic cortex, and the infralimbic cortex. Functions Evidence shows that the dmPFC plays several roles in humans. The dmPFC is identified to play roles in processing a sense of self, integrating social impressions, theory of mind, morality judgments, empathy, decision making, altruism, fear and anxiety information processing, and top-down motor cortex inhibition The dmPFC also modulates or regulates emotional responses and heart rate in situations of fear or stress and plays a role in long-term memory ). Some argue that the dmPFC is made up of several smaller subregions that are more task-specific. The dmPFC is attributed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prefrontal Cortex
In mammalian brain anatomy, the prefrontal cortex (PFC) covers the front part of the frontal lobe of the cerebral cortex. The PFC contains the Brodmann areas BA8, BA9, BA10, BA11, BA12, BA13, BA14, BA24, BA25, BA32, BA44, BA45, BA46, and BA47. The basic activity of this brain region is considered to be orchestration of thoughts and actions in accordance with internal goals. Many authors have indicated an integral link between a person's will to live, personality, and the functions of the prefrontal cortex. This brain region has been implicated in executive functions, such as planning, decision making, short-term memory, personality expression, moderating social behavior and controlling certain aspects of speech and language. Executive function relates to abilities to differentiate among conflicting thoughts, determine good and bad, better and best, same and different, future consequences of current activities, working toward a defined goal, prediction of outcom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anterior Cingulate Cortex
In the human brain The human brain is the central organ (anatomy), organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the act ..., the anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles a "collar" surrounding the frontal part of the corpus callosum. It consists of Brodmann areas Brodmann area 24, 24, Brodmann area 32, 32, and Brodmann area 33, 33. It is involved in certain higher-level functions, such as attention allocation, pavlovian conditioning, reward anticipation, decision-making, ethics and morality, impulse control (e.g. performance monitoring and error detection), and emotion. Anatomy The anterior cingulate cortex can be divided anatomically based on cognitive (Dorsum (biology), dorsal), and emotional (ventral) components. The dorsal part of the ACC is connected with the prefrontal corte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Self-model Theory Of Subjectivity
The self-model is the central concept in the theory of consciousness called the self-model theory of subjectivity (SMT). This concept comprises experiences of ownership, of first person perspective, and of a long-term unity of beliefs and attitudes. These features are instantiated in the prefrontal cortex. This theory is an interdisciplinary approach to understanding and explaining the phenomenology of consciousness and the self. This theory has two core contents, the phenomenal self-model (PSM) and the phenomenal model of the intentionality relation (PMIR). Thomas Metzinger advanced the theory in his 1993 book ''Subjekt und Selbstmodell'' (Subject and self-model). Overview of the PSM The PSM is an entity that "actually exists, not only as a distinct theoretical entity but something that will be empirically discovered in the future—for instance, as a specific stage of the global neural dynamics in the human brain". Involved in the PSM are three phenomenal properties that must occu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'', also widely referred to as ''Science Magazine'', is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature'' cover the full r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optogenetics
Optogenetics is a biological technique to control the activity of neurons or other cell types with light. This is achieved by expression of light-sensitive ion channels, pumps or enzymes specifically in the target cells. On the level of individual cells, light-activated enzymes and transcription factors allow precise control of biochemical signaling pathways. In systems neuroscience, the ability to control the activity of a genetically defined set of neurons has been used to understand their contribution to decision making, learning, fear memory, mating, addiction, feeding, and locomotion. In a first medical application of optogenetic technology, vision was partially restored in a blind patient. Optogenetic techniques have also been introduced to map the functional connectivity of the brain''.'' By altering the activity of genetically labelled neurons with light and using imaging and electrophysiology techniques to record the activity of other cells, researchers can identify ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theory Of Mind
In psychology, theory of mind refers to the capacity to understand other people by ascribing mental states to them (that is, surmising what is happening in their mind). This includes the knowledge that others' mental states may be different from one's own states and include beliefs, desires, intentions, emotions, and thoughts. Possessing a functional theory of mind is considered crucial for success in everyday human social interactions. People use such a theory when analyzing, judging, and inferring others' behaviors. The discovery and development of theory of mind primarily came from studies done with animals and infants. Factors including drug and alcohol consumption, language development, cognitive delays, age, and culture can affect a person's capacity to display theory of mind. It has been proposed that deficits in theory of mind can occur in people with autism (although this is contentious), anorexia nervosa, schizophrenia, dysphoria, attention deficit hyperactiv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcranial Magnetic Stimulation
Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation in which a changing magnetic field is used to induce an electric current at a specific area of the brain through electromagnetic induction. An electric pulse generator, or stimulator, is connected to a magnetic coil connected to the scalp. The stimulator generates a changing electric current within the coil which creates a varying magnetic field, inducing a current within a region in the brain itself.NICE. January 201Transcranial magnetic stimulation for treating and preventing migraine/ref>Michael Craig Miller for Harvard Health Publications. July 26, 201Magnetic stimulation: a new approach to treating depression?/ref> TMS has shown diagnostic and therapeutic potential in the central nervous system with a wide variety of disease states in neurology and mental health, with research still evolving. Adverse effects of TMS appear rare and include fainting and seizure. Other potential issues includ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Functional Magnetic Resonance Imaging
Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases. The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa in 1990. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not involve the use of injections, surgery, the ingestion of substances, or exposure to ionizing radiation. This measure is frequently corrupted by noise from various sources; hence, statistical procedures are used to extract the underlying signal. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infralimbic Cortex
The infralimbic cortex (IL) is a cortical region in the ventromedial prefrontal cortex which is important in tonic inhibition of subcortical structures and emotional responses, such as fear. Structure Connectivity Primates GABAergic neurons within the amygdala, known as intercalated (ITC) cells, receive a strong projection from the IL medial prefrontal cortex (mPFC) in primates. ITC cells are thought to play a role as the 'off switch' for the amygdala, inhibiting the amygdala's central nucleus output neurons and its basolateral nucleus neurons.Quirk, G.J. & Mueller, D. (2007). Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology Reviews, 1-17. Further, it has been shown that electrical stimulation of IL reduces conditioned fear and strengthens extinction memory, explaining cortical control over extinction processes, one of the simplest forms of emotional regulation. Rodents Amygdala ITC cells receive strong projection from the IL mPFC in rodents as w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prelimbic Cortex
The dorsomedial prefrontal cortex (dmPFC or DMPFC is a section of the prefrontal cortex in some species' brain anatomy. It includes portions of Brodmann areas BA8, BA9, BA10, BA24 and BA32, although some authors identify it specifically with BA8 and BA9 Some notable sub-components include the dorsal anterior cingulate cortex (BA24 and BA32), the prelimbic cortex, and the infralimbic cortex. Functions Evidence shows that the dmPFC plays several roles in humans. The dmPFC is identified to play roles in processing a sense of self, integrating social impressions, theory of mind, morality judgments, empathy, decision making, altruism, fear and anxiety information processing, and top-down motor cortex inhibition The dmPFC also modulates or regulates emotional responses and heart rate in situations of fear or stress and plays a role in long-term memory ). Some argue that the dmPFC is made up of several smaller subregions that are more task-specific. The dmPFC is attribute ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brodmann Area 32
The Brodmann area 32, also known in the human brain as the dorsal anterior cingulate area 32, refers to a subdivision of the cytoarchitecturally defined cingulate cortex. In the human it forms an outer arc around the anterior cingulate gyrus. The cingulate sulcus defines approximately its inner boundary and the superior rostral sulcus (H) its ventral boundary; rostrally it extends almost to the margin of the frontal lobe. Cytoarchitecturally it is bounded internally by the ventral anterior cingulate area 24, externally by medial margins of the agranular frontal area 6, intermediate frontal area 8, granular frontal area 9, frontopolar area 10, and prefrontal area 11-1909. (Brodmann19-09). The dorsal region of the anterior cingulate gyrus is associated with rational thought processes, most notably active during the Stroop task. Guenon In the guenon, Brodmann area 32 is a subdivision of the cytoarchitecturally defined cingulate region of cerebral cortex. This area was named ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anterior Cingulate Cortex
In the human brain The human brain is the central organ (anatomy), organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the act ..., the anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles a "collar" surrounding the frontal part of the corpus callosum. It consists of Brodmann areas Brodmann area 24, 24, Brodmann area 32, 32, and Brodmann area 33, 33. It is involved in certain higher-level functions, such as attention allocation, pavlovian conditioning, reward anticipation, decision-making, ethics and morality, impulse control (e.g. performance monitoring and error detection), and emotion. Anatomy The anterior cingulate cortex can be divided anatomically based on cognitive (Dorsum (biology), dorsal), and emotional (ventral) components. The dorsal part of the ACC is connected with the prefrontal corte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
