Dictyophorine
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Dictyophorine
Dictyophorines are a pair of sesquiterpenes isolated from the fungus ''Phallus indusiatus'' (''Dictyophora indusiata''). These compounds are based on the eudesmane skeleton, a common structure found in plant-derived flavors and fragrances, and they are the first eudesmane derivatives isolated from fungi. Dictyophorines A and B promote the synthesis of nerve growth factor in astroglial cells. Eudesmano - numeración.png, The eudesmane skeleton upon which dictyophorines are based Dictyophora indusiata Feb 2010.JPG, ''Phallus indusiatus ''Phallus indusiatus'', commonly called the bamboo mushrooms, bamboo pith, long net stinkhorn, crinoline stinkhorn or veiled lady, is a fungus in the family Phallaceae, or stinkhorns. It has a cosmopolitan distribution in tropical areas, and ...'', in Cooktown, Queensland, Australia, which produces dictyophorines References Sesquiterpenes {{organic-compound-stub ...
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Phallus Indusiatus
''Phallus indusiatus'', commonly called the bamboo mushrooms, bamboo pith, long net stinkhorn, crinoline stinkhorn or veiled lady, is a fungus in the family Phallaceae, or stinkhorns. It has a cosmopolitan distribution in tropical areas, and is found in southern Asia, Africa, the Americas, and Australia, where it grows in woodlands and gardens in rich soil and well-rotted woody material. The fruit body of the fungus is characterised by a conical to bell-shaped cap on a stalk and a delicate lacy "skirt", or indusium, that hangs from beneath the cap and reaches nearly to the ground. First described scientifically in 1798 by French botanist Étienne Pierre Ventenat, the species has often been referred to a separate genus ''Dictyophora'' along with other ''Phallus'' species featuring an indusium. ''P. indusiatus'' can be distinguished from other similar species by differences in distribution, size, color, and indusium length. Mature fruit bodies are up to tall with a coni ...
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Sesquiterpenes
Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be cyclic or contain rings, including many unique combinations. Biochemical modifications such as oxidation or rearrangement produce the related sesquiterpenoids. Sesquiterpenes are found naturally in plants and insects, as semiochemicals, e.g. defensive agents or pheromones. Biosynthesis and examples The reaction of geranyl pyrophosphate with isopentenyl pyrophosphate results in the 15-carbon farnesyl pyrophosphate (FPP), which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. Cyclic sesquiterpenes are more common than cyclic monoterpenes because of the increased chain length and additional double bond in the sesquiterpene precursors. In addition to common six-membered ring systems such as the ones found in zingiberene and bisacurone, cyclization of one end of the chain to the other end can l ...
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Derivative (chemistry)
In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction. In the past, derivative also meant a compound that ''can be imagined to'' arise from another compound, if one atom or group of atoms is replaced with another atom or group of atoms, but modern chemical language now uses the term structural analog for this meaning, thus eliminating ambiguity. The term "structural analogue" is common in organic chemistry. In biochemistry, the word is used for compounds that at least theoretically can be formed from the precursor compound. Chemical derivatives may be used to facilitate analysis. For example, melting point (MP) analysis can assist in identification of many organic compounds. A crystalline derivative may be prepared, such as a semicarbazone or 2,4-dinitrophenylhydrazone (derived from aldehydes or ketones), as a simple way of verifying the identity of the original compound, assuming that a table of derivative MP values is available ...
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Nerve Growth Factor
Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described. Since it was first isolated by Nobel Laureates Rita Levi-Montalcini and Stanley Cohen in 1956, numerous biological processes involving NGF have been identified, two of them being the survival of pancreatic beta cells and the regulation of the immune system. Structure NGF is initially in a 7S, 130-kDa complex of 3 proteins – Alpha-NGF, Beta-NGF, and Gamma-NGF (2:1:2 ratio) when expressed. This form of NGF is also referred to as proNGF (NGF precursor). The gamma subunit of this complex acts as a serine protease, and cleaves the N-terminal of the beta subunit, thereby activating the protein into functional NGF. The term ''nerve growth factor'' usually refers to the 2.5S, 26-kDa beta subunit of the protein ...
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Astroglial Cell
Astrocytes (from Ancient Greek , , "star" + , , "cavity", "cell"), also known collectively as astroglia, are characteristic star-shaped glial cells in the brain and spinal cord. They perform many functions, including biochemical control of endothelial cells that form the blood–brain barrier, provision of nutrients to the nervous tissue, maintenance of extracellular ion balance, regulation of cerebral blood flow, and a role in the repair and scarring process of the brain and spinal cord following infection and traumatic injuries. The proportion of astrocytes in the brain is not well defined; depending on the counting technique used, studies have found that the astrocyte proportion varies by region and ranges from 20% to 40% of all glia. Another study reports that astrocytes are the most numerous cell type in the brain. Astrocytes are the major source of cholesterol in the central nervous system. Apolipoprotein E transports cholesterol from astrocytes to neurons and other glial ...
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Cooktown, Queensland
Cooktown is a coastal town and locality in the Shire of Cook, Queensland, Australia. Cooktown is at the mouth of the Endeavour River, on Cape York Peninsula in Far North Queensland where James Cook beached his ship, the Endeavour, for repairs in 1770. Both the town and Mount Cook (431 metres or 1,415 feet) which rises up behind the town were named after James Cook. Cooktown is one of the few large towns in the Cape York Peninsula and was founded on 25 October 1873 as a supply port for the goldfields along the Palmer River.Pike (1979), p. 23.Holthouse, Hector (1967). ''River of Gold: The Wild Days of the Palmer River Gold Rush''. Angus & Robertson. Reprint 2002. HarperCollins ''Publishers'', Australia. ; pp. 27–28. It was called "Cook's Town" until 1 June 1874.Pike (1979), p. 26. In the the locality of Cooktown had a population of 2,631 people. Geography Cooktown is located about north of Brisbane and north of Cairns, by road. Cooktown is about south of Cape York by ro ...
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