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Dichloroacetyl Chloride
Dichloroacetyl chloride is the organic compound with the formula CHCl2COCl. It is the acyl chloride of dichloroacetic acid. It is a colourless liquid and is used in acylation reactions. Preparation Unlike typical acid chlorides, dichloroacetyl chloride is not prepared from the acid. Industrial routes include oxidation of 1,1,2-trichloroethane, hydrolysis of pentachloroethane, and the carboxylation of chloroform: :CHCl2CH2Cl + O2 → CHCl2COCl + H2O :CHCl2CCl3 + H2O → CHCl2COCl + 2 HCl :CHCl3 + CO2 → CHCl2COCl + 1/2 O2 Uses Hydrolysis gives dichloroacetic acid Dichloroacetic acid (DCA), sometimes called bichloroacetic acid (BCA), is the chemical compound with formula . It is an acid, an analogue of acetic acid, in which 2 of the 3 hydrogen atoms of the methyl group have been replaced by chlorine atoms. .... It is one of the precursors to antibiotics, including chloramphenicol. Another reported use was in the synthesis of WIN 18,446. Reference ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The study of the properties, reactions, and syntheses of organic compounds comprise the discipline known as organic chemistry. For historical reasons, a few classes of carbon-containing compounds (e.g., carbonate salts and cyanide salts), along with a few other exceptions (e.g., carbon dioxide, hydrogen cyanide), are not classified as organic compounds and are considered inorganic. Other than those just named, little consensus exists among chemists on precisely which carbon-containing compounds are excluded, making any rigorous definition of an organic compound elusive. Although organic compounds make up only a small percentage of Earth's crust, they are of central importance because all known life is based on organic compounds. Living t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acyl Chloride
In organic chemistry, an acyl chloride (or acid chloride) is an organic compound with the functional group . Their formula is usually written , where R is a side chain. They are reactive derivatives of carboxylic acids (). A specific example of an acyl chloride is acetyl chloride, . Acyl chlorides are the most important subset of acyl halides. Nomenclature Where the acyl chloride moiety takes priority, acyl chlorides are named by taking the name of the parent carboxylic acid, and substituting ''-yl chloride'' for ''-ic acid''. Thus: : : When other functional groups take priority, acyl chlorides are considered prefixes — ''chlorocarbonyl-'': : Properties Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1. The simplest s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dichloroacetic Acid
Dichloroacetic acid (DCA), sometimes called bichloroacetic acid (BCA), is the chemical compound with formula . It is an acid, an analogue of acetic acid, in which 2 of the 3 hydrogen atoms of the methyl group have been replaced by chlorine atoms. Like the other chloroacetic acids, it has various practical applications. The salts and esters of dichloroacetic acid are called dichloroacetates. Salts of DCA have been studied as potential drugs because they inhibit the enzyme pyruvate dehydrogenase kinase. Although preliminary studies found that DCA can slow the growth of certain tumors in animal studies and ''in vitro'' studies, as of 2012 insufficient evidence supported the use of DCA for cancer treatment. Chemistry and occurrence The chemistry of dichloroacetic acid is typical for halogenated organic acids. It is a member of the chloroacetic acids family. The dichloroacetate ion is produced when the acid is mixed with water. As an acid with a p''K''a of 1.35, pure dichloroacetic a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acylation
In chemistry, acylation (or alkanoylation) is the chemical reaction in which an acyl group () is added to a compound. The compound providing the acyl group is called the acylating agent. Because they form a strong electrophile when treated with some metal catalysts, acyl halides are commonly used as acylating agents. For example, Friedel–Crafts acylation uses acetyl chloride (ethanoyl chloride or ) as the agent and aluminum chloride () as a catalyst to add an ethanoyl ( acetyl) group to benzene: The mechanism of this reaction is electrophilic aromatic substitution. Acyl halides and acid anhydrides of carboxylic acids are also commonly used acylating agents. In some cases, active esters exhibit comparable reactivity. All react with amines to form amides and with alcohols to form esters by nucleophilic acyl substitution. Acylation can be used to prevent rearrangement reactions that would normally occur in alkylation. To do this an acylation reaction is performed, then the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pentachloroethane
Pentachloroethane is a chemical compound of chlorine, hydrogen, and carbon with the chemical formula . It is a colourless non-flammable liquid that is used as a solvent for oil and grease, in metal cleaning, and in the separation of coal from impurities. Production and uses Victor Regnault obtained Pentachloroethane from chlorination of various chlorinated ethanes in 1839. Pentachloroethane can be obtained by chlorination of trichloroethylene and ethylene-catalysed chlorination of 1,2-dichloroethane. Pentachloroethane can also be obtained by the reaction of acetylene and chlorine, catalysed by aluminium chloride and antimony trichloride.Jian, Panming; He, YongzhiMethod for producing pentachloroethane using acetylene and chlorine 2018. CN 108546228 A It can be made as a byproduct of tetrachloroethylene production. Pentachloroethane has limited uses as a solvent for oils and grease (especially in metal cleaning), in soil sterilisation, to remove impurities in coal and as a desic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chloroform
Chloroform, or trichloromethane, is an organic compound with chemical formula, formula Carbon, CHydrogen, HChlorine, Cl3 and a common organic solvent. It is a colorless, strong-smelling, dense liquid produced on a large scale as a precursor to PTFE. It is also a precursor to various refrigerants. It is trihalomethane. It is a powerful anesthetic, euphoriant, anxiolytic, and sedative when inhaled or ingested. Structure The molecule adopts a tetrahedral molecular geometry with C3v symmetry group, symmetry. Natural occurrence The total global flux of chloroform through the environment is approximately tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Abiotic processes are also believed to contribute to natural chloroform productions in soils although the mechanism is still unclear. Chloroform volatilizes readily from soil and surface water and undergoes degradation in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chloramphenicol
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. Its use by mouth or by injection is only recommended when safer antibiotics cannot be used. Monitoring both blood levels of the medication and blood cell levels every two days is recommended during treatment. Common side effects include bone marrow suppression, nausea, and diarrhea. The bone marrow suppression may result in death. To reduce the risk of side effects treatment duration should be as short as possible. People with liver or kidney problems may need lower doses. In young children a condition known as gray baby syndrome may occur which results in a swollen stomach and low blood pressure. Its use near the end of pregnancy and during breastfeeding is typically not recommended. Chloramphenicol is a broad-spectrum ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WIN 18,446
Win or WIN may refer to: * A victory Arts and entertainment Film * ''Win!'', a 2016 American film Literature * ''Win'' (Coben novel), a 2121 novel by Harlan Coben * WIN (pacifist magazine), published by the War Resisters League * WIN (wrestling magazine), American high school and college amateur wrestling publication Music * Win (band), a Scottish band * "Win" (song), by Jay Rock * "Win", a song by Brian McKnight from the album ''Gold'' * "Win", a song by David Bowie from the album ''Young Americans'' * "Win", a song by Stefflon Don and DJ Khaled from the mixtape ''Secure'' * Worldwide Independent Network (WIN), a coalition of independent music bodies, see Independent record label#Worldwide Independent Network (WIN)) Television and radio * DWNU or Win Radio, a Filipino radio station * Win FM, an Indian radio station * WIN Television, an Australian television network ** WIN Corporation, the owner of WIN Television ** WIN News, the news service for WIN Television ** WIN (TV ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
