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Delayed Gadolinium-enhanced Magnetic Resonance Imaging Of Cartilage
Delayed gadolinium-enhanced magnetic resonance imaging of cartilage or dGEMRIC measures the fixed-charge density and relative proteoglycan content of articular cartilage Cartilage is a resilient and smooth type of connective tissue. In tetrapods, it covers and protects the ends of long bones at the joints as articular cartilage, and is a structural component of many body parts including the rib cage, the neck an ... using the spin-lattice relaxation time or T1 relaxation time. Current research is investigating the clinical application of dGEMRIC as a quantitative tool for monitoring cartilage function in diseased or repair cartilage. References External linksThe Impact of the Relaxivity Definition on the Quantitative Measurement of Glycosaminoglycans in Cartilage by MRI dGEMRIC Method [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteoglycan
Proteoglycans are proteins that are heavily glycosylated. The basic proteoglycan unit consists of a "core protein" with one or more covalently attached glycosaminoglycan (GAG) chain(s). The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge (e.g. chondroitin sulfate- GlcA- Gal-Gal- Xyl-PROTEIN). The Ser residue is generally in the sequence -Ser-Gly-X-Gly- (where X can be any amino acid residue but proline), although not every protein with this sequence has an attached glycosaminoglycan. The chains are long, linear carbohydrate polymers that are negatively charged under physiological conditions due to the occurrence of sulfate and uronic acid groups. Proteoglycans occur in connective tissue. Types Proteoglycans are categorized by their relative size (large and small) and the nature of their glycosaminoglycan chains. Types include: Certain members are considered members of the "small leucine-rich proteoglyc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cartilage
Cartilage is a resilient and smooth type of connective tissue. In tetrapods, it covers and protects the ends of long bones at the joints as articular cartilage, and is a structural component of many body parts including the rib cage, the neck and the bronchial tubes, and the intervertebral discs. In other taxa, such as chondrichthyans, but also in cyclostomes, it may constitute a much greater proportion of the skeleton. It is not as hard and rigid as bone, but it is much stiffer and much less flexible than muscle. The matrix of cartilage is made up of glycosaminoglycans, proteoglycans, collagen fibers and, sometimes, elastin. Because of its rigidity, cartilage often serves the purpose of holding tubes open in the body. Examples include the rings of the trachea, such as the cricoid cartilage and carina. Cartilage is composed of specialized cells called chondrocytes that produce a large amount of collagenous extracellular matrix, abundant ground substance that is rich in pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T1 Relaxation
T1, T01, T.1 or T-1 may refer to: Biology * The first of the thoracic vertebrae in the vertebral column * Thoracic spinal nerve 1, a nerve emerging from the vertebrae * Cyclin T1, a human gene * GalNAc-T1, a human gene * Ribonuclease T1, a fungal endonuclease * TNM staging system, classification for a small cancer tumor Computing * Apple T1, a system on a chip used by Apple * T1 font, or cork encoding, a character encoding * T1, a component of the T-carrier system for telecommunication * UltraSPARC T1, a microprocessor Transportation Aircraft * Raytheon T-1 Jayhawk, a jet aircraft used by the US Air Force for advanced pilot training * Lockheed T2V SeaStar, a.k.a. T1 Seastar, a carrier-capable jet trainer in the US Navy * Fuji T-1, Japan's first jet-powered trainer aircraft * Sopwith Cuckoo, a British biplane torpedo bomber of 1918 Automobiles * Bentley T-series, Bentley Motors model in the UK * Caparo T1, a 2006 British sports car * CWS T-1, first serially-built car manufactur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
