|
Dafachronic Acid
Dafachronic acids are steroid hormones activate the nuclear receptor Daf-12/NR1J1 in ''Caenorhabditis elegans'' and related organisms, include Δ4-dafachronic acid and Δ7-dafachronic acid. Both are generated by Daf-9 The Daf-9 gene encodes a cytochrome p450 enzyme catalysis the generation of dafachronic acid (a steroid hormone) in the worm ''Caenorhabditis elegans'', with the CYP Symbol CYP22A1 (Cytochrome P450, family 22, member A1). After generation, dafachro .../CYP22A1 from respective precursors. References {{Reflist Steroid hormones ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroid Hormone
A steroid hormone is a steroid that acts as a hormone. Steroid hormones can be grouped into two classes: corticosteroids (typically made in the adrenal cortex, hence ''cortico-'') and sex steroids (typically made in the gonads or placenta). Within those two classes are five types according to the receptors to which they bind: glucocorticoids and mineralocorticoids (both corticosteroids) and androgens, estrogens, and progestogens (sex steroids). Vitamin D derivatives are a sixth closely related hormone system with homologous receptors. They have some of the characteristics of true steroids as receptor ligands. Steroid hormones help control metabolism, inflammation, immune functions, salt and water balance, development of sexual characteristics, and the ability to withstand injury and illness. The term steroid describes both hormones produced by the body and artificially produced medications that duplicate the action for the naturally occurring steroids. Synthesis The nat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These receptors work with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often occurs in the presence of a ligand—a molecule that affects the receptor's behavior. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up- or down-regulation of gene expression. A unique property of nuclear receptors that differentiates them from other classes of receptors is their direct control of genomic DNA. Nuclear receptors play key roles in both embryonic development a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daf-12
The DAF-12 (abnormal dauer formation protein 12) gene encodes the nuclear receptor of dafachronic acid (a steroid hormone) in the worm ''Caenorhabditis elegans'', with the NRNC Symbol NR1J1 as the homolog of nuclear hormone receptor HR96''Hr96'' in Drosophila melanogaster. DAF-12 has been implicated by Cynthia Kenyon and colleagues in the formation of Dauer larva. In favorable environments, a cytochrome p450 Daf-9 (Cyp22a1) produce dafachronic acid to binding Daf-12 to initiating downstream gene expression. When in infavorable environments, like starvation, dafachronic acid decreases, Daf-12 will form a complex with co-repressor In molecular genetics, a repressor is a DNA- or RNA-binding protein that inhibits the expression of one or more genes by binding to the operator or associated silencers. A DNA-binding repressor blocks the attachment of RNA polymerase to the ... DIN-1. References {{Dauer larva Caenorhabditis elegans genes 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caenorhabditis Elegans
''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a blend of the Greek ''caeno-'' (recent), ''rhabditis'' (rod-like) and Latin ''elegans'' (elegant). In 1900, Maupas initially named it '' Rhabditides elegans.'' Osche placed it in the subgenus ''Caenorhabditis'' in 1952, and in 1955, Dougherty raised ''Caenorhabditis'' to the status of genus. ''C. elegans'' is an unsegmented pseudocoelomate and lacks respiratory or circulatory systems. Most of these nematodes are hermaphrodites and a few are males. Males have specialised tails for mating that include spicules. In 1963, Sydney Brenner proposed research into ''C. elegans,'' primarily in the area of neuronal development. In 1974, he began research into the molecular and developmental biology of ''C. elegans'', which has since been extensively used as a model organism. It was the first multicellu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Chromatography B
The ''Journal of Chromatography B'' is a Peer review, peer-reviewed scientific journal publishing research papers in analytical chemistry, with a focus on chromatography techniques and methods in the biological and life sciences. According to the ''Journal Citation Reports'', 'Journal of Chromatography B'' has a 2020 impact factor of 3.205, ranking it 36th out of 83 in the category of Chemistry, Analytical. See also * Journal of Chromatography A References Publications established in 1958 Elsevier academic journals Chemistry journals {{chemistry-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daf-9
The Daf-9 gene encodes a cytochrome p450 enzyme catalysis the generation of dafachronic acid (a steroid hormone) in the worm ''Caenorhabditis elegans'', with the CYP Symbol CYP22A1 (Cytochrome P450, family 22, member A1). After generation, dafachronic acid will binding it's nuclear receptor Daf-12 and has been implicated by Cynthia Kenyon and colleagues related to the formation of Dauer larva Dauer (German "''die Dauer''", English "the enduring", "the duration" in the meaning of "a length of time",) describes an alternative developmental stage of nematode worms, particularly rhabditids including '' Caenorhabditis elegans'', whereby the .... References {{Dauer larva Caenorhabditis elegans genes 22 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frontiers In Endocrinology
''Frontiers in Endocrinology'' is a peer-reviewed open access scientific journal covering all aspects of endocrinology in 21 sections. It was established in 2010 and is published by Frontiers Media. The editor-in-chief is Jeffrey M. P. Holly (University of Bristol). Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has an impact factor of 6.055 in 2021 History From 1993 to 1995 a monographic series named ''Frontiers in Endocrinology'' () was published by Ares-Serono Symposia Publications for 15 volumes. The current journal was established in 2010. In order to distinguish the two periodicals some indices use the names ''Frontiers in Endocrinology (Rome, Italy)'' for the older series and ''Frontiers in Endocrinology (Lausanne)'' for the current journal. References External links * {{Official website, https://www.frontiersin.org/journals/endocrinology English-language journals Endocrinology journals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
