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Cytoplasmic Hybrid
A cytoplasmic hybrid (or cybrid, a portmanteau of the two words) is a eukaryotic cell line produced by the fusion of a whole cell with a cytoplast. Cytoplasts are enucleated cells. This enucleation can be effected by simultaneous application of centrifugal force and treatment of the cell with an agent that disrupts the cytoskeleton. A special case of cybrid formation involves the use of ''rho-zero'' cells as the whole cell partner in the fusion. Rho-zero cells are cells which have been depleted of their own mitochondrial DNA by prolonged incubation with ethidium bromide, a chemical which inhibits mitochondrial DNA replication. The rho-zero cells do retain mitochondria and can grow in rich culture medium with certain supplements. They do retain their own nuclear genome. A cybrid is then a hybrid cell which mixes the nuclear genes from one cell with the mitochondrial genes from another cell. Using this powerful tool, it makes it possible to dissociate contribution from the mitoc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Nucleus
The cell nucleus (pl. nuclei; from Latin or , meaning ''kernel'' or ''seed'') is a membrane-bound organelle found in eukaryotic cells. Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others including osteoclasts have many. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm; and the nuclear matrix, a network within the nucleus that adds mechanical support. The cell nucleus contains nearly all of the cell's genome. Nuclear DNA is often organized into multiple chromosomes – long stands of DNA dotted with various proteins, such as histones, that protect and organize the DNA. The genes within these chromosomes are structured in such a way to promote cell function. The nucleus maintains the integrity of genes and controls the activities of the cell by regulating gene expres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The National Archives (United Kingdom)
, type = Non-ministerial department , seal = , nativename = , logo = Logo_of_The_National_Archives_of_the_United_Kingdom.svg , logo_width = 150px , logo_caption = , formed = , preceding1 = , dissolved = , superseding = , jurisdiction = England and Wales, HM Government , headquarters = Kew, Richmond, Greater London TW9 4DU , region_code = GB , coordinates = , employees = 679 , budget = £43.9 million (2009–2010) , minister1_name = Michelle Donelan , minister1_pfo = Secretary of State for Digital, Culture, Media and Sport , minister2_name = TBC , minister2_pfo = Parliamentary Under Secretary of State , chief1_name = Jeff James , chief1_position = Chief Executive and Keeper of the Public Records , chief2_name = , chief2_position = , chief3_name = , chief3_position = , chief4_name = , chief4_position = , chief5_name = , chief5_position = , agency_type = , chief6_name = , chief6_position = , chief7_name = , chief7_position = ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Feminist Legal Studies
''Feminist Legal Studies'' is a triannual peer-reviewed legal journal with an international perspective that focuses on feminist work in all areas of law, legal theory, and legal practice. The journal often publishes critical, interdisciplinary, theoretical feminist studies relevant to law. It is further extended by generating analyzes and debates on women's rights across approaches, critical perspectives, and theories. Feminist Legal Studies focuses not only on post-colonial tasks but also covers the field of law, legal theory, and legal practice in transnational jurisdictions. The journal was established in 1993 and is published by Springer Science+Business Media, Springer. The editor-in-chief is Ruth Fletcher (Queen Mary University of London). Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor of 2.259, ranking it 28th out of 144 journals in the category "Gender Studies". Se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of GlaxoSmithKline) to fund research to improve human and animal health. The aim of the Trust is to "support science to solve the urgent health challenges facing everyone." It had a financial endowment of Pound sterling, £29.1 billion in 2020, making it the fourth List of wealthiest charitable foundations, wealthiest charitable foundation in the world. In 2012, the Wellcome Trust was described by the ''Financial Times'' as the United Kingdom's largest provider of non-governmental funding for scientific research, and one of the largest providers in the world. According to their annual report, the Wellcome Trust spent GBP Pound sterling, £1.1Bn on charitable activities across their 2019/2020 financial year. According to the OECD, the Wellcome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BBC News Online
BBC News Online is the website of BBC News, the division of the BBC responsible for newsgathering and production. It is one of the most popular news websites, with 1.2 billion website visits in April 2021, as well as being used by 60% of the UK's internet users for news. The website contains international news coverage, as well as British, entertainment, science, and political news. Many reports are accompanied by audio and video from the BBC's television and radio news services, while the latest TV and radio bulletins are also available to view or listen to on the site together with other current affairs programmes. BBC News Online is closely linked to its sister department website, that of BBC Sport. Both sites follow similar layout and content options and respective journalists work alongside each other. Location information provided by users is also shared with the website of BBC Weather to provide local content. From 1998 to 2001 the site was named best news website at t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Department Of Health (United Kingdom)
The Department of Health and Social Care (DHSC) is a department of His Majesty's Government responsible for government policy on health and adult social care matters in England, along with a few elements of the same matters which are not otherwise devolved to the Scottish Government, Welsh Government or Northern Ireland Executive. It oversees the English National Health Service (NHS). The department is led by the secretary of state for health and social care with three ministers of state and three parliamentary under-secretaries of state. The department develops policies and guidelines to improve the quality of care and to meet patient expectations. It carries out some of its work through arms-length bodies (ALBs), including executive non-departmental public bodies such as NHS England and the NHS Digital, and executive agencies such as the UK Health Security Agency and the Medicines and Healthcare products Regulatory Agency (MHRA). The DHSC also manages the work of the Nation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Fertilisation And Embryology Act 2008
The Human Fertilisation and Embryology Act 2008 (c 22) is an Act of the Parliament of the United Kingdom. The Act constitutes a major review and update of the Human Fertilisation and Embryology Act 1990. According to the Department of Health the Act's key provisions are: The Bill's discussion in Parliament did not permit time to debate whether it should extend abortion rights under the Abortion Act 1967 to also cover Northern Ireland. The 2008 Act does not alter the status quo. The Act also repealed and replaced the Human Reproductive Cloning Act 2001. References Further reading *Human Fertilisation and Embryology Actat the Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ... * * External linksThe Human Fertilisation and Embryology Act 2008 as amended from the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British House Of Lords
The House of Lords, also known as the House of Peers, is the upper house of the Parliament of the United Kingdom. Membership is by appointment, heredity or official function. Like the House of Commons, it meets in the Palace of Westminster in London, England. The House of Lords scrutinises bills that have been approved by the House of Commons. It regularly reviews and amends bills from the Commons. While it is unable to prevent bills passing into law, except in certain limited circumstances, it can delay bills and force the Commons to reconsider their decisions. In this capacity, the House of Lords acts as a check on the more powerful House of Commons that is independent of the electoral process. While members of the Lords may also take on roles as government ministers, high-ranking officials such as cabinet ministers are usually drawn from the Commons. The House of Lords does not control the term of the prime minister or of the government. Only the lower house may force the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkinson's Disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms become more common. The most obvious early symptoms are tremor, rigidity, slowness of movement, and difficulty with walking. Cognitive and behavioral problems may also occur with depression, anxiety, and apathy occurring in many people with PD. Parkinson's disease dementia becomes common in the advanced stages of the disease. Those with Parkinson's can also have problems with their sleep and sensory systems. The motor symptoms of the disease result from the death of cells in the substantia nigra, a region of the midbrain, leading to a dopamine deficit. The cause of this cell death is poorly understood, but involves the build-up of misfolded proteins into Lewy bodies in the neurons. Collectively, the main motor symptoms are also known as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term memory, remembering recent events. As the disease advances, symptoms can include primary progressive aphasia, problems with language, Orientation (mental), disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and challenging behaviour, behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an alle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitochondrial Genes
Mitochondrial DNA (mtDNA or mDNA) is the DNA located in mitochondria, cellular organelles within eukaryotic cells that convert chemical energy from food into a form that cells can use, such as adenosine triphosphate (ATP). Mitochondrial DNA is only a small portion of the DNA in a eukaryotic cell; most of the DNA can be found in the cell nucleus and, in plants and algae, also in plastids such as chloroplasts. Human mitochondrial DNA was the first significant part of the human genome to be sequenced. This sequencing revealed that the human mtDNA includes 16,569 base pairs and encodes 13 proteins. Since animal mtDNA evolves faster than nuclear genetic markers, it represents a mainstay of phylogenetics and evolutionary biology. It also permits an examination of the relatedness of populations, and so has become important in anthropology and biogeography. Origin Nuclear and mitochondrial DNA are thought to be of separate evolutionary origin, with the mtDNA being derived ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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