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Creode
Creode or chreod is a neologistic portmanteau term coined by the English 20th century biologist C. H. Waddington to represent the developmental pathway followed by a cell as it grows to form part of a specialized organ. Combining the Greek roots for "necessary" and "path," the term was inspired by the property of regulation. When development is disturbed by external forces, the embryo attempts to regulate its growth and differentiation by returning to its normal developmental trajectory. Developmental biology Waddington used the term along with canalisation and homeorhesis, which describes a system that returns to a steady trajectory, in contrast to homeostasis, which describes a system which returns to a steady state. Waddington explains development with the metaphor of a ball rolling down a hillside, where the hill's contours channel the ball in a particular direction. In the case of a pathway or creode which is deeply carved in the hillside, external disturbance is unlikely to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canalisation (genetics)
Canalisation is a measure of the ability of a population to produce the same phenotype regardless of variability of its environment or genotype. It is a form of evolutionary robustness. The term was coined in 1942 by C. H. Waddington to capture the fact that "developmental reactions, as they occur in organisms submitted to natural selection...are adjusted so as to bring about one definite end-result regardless of minor variations in conditions during the course of the reaction". He used this word rather than robustness to take into account that biological systems are not robust in quite the same way as, for example, engineered systems. Biological robustness or canalisation comes about when developmental pathways are shaped by evolution. Waddington introduced the concept of the epigenetic landscape, in which the state of an organism rolls "downhill" during development. In this metaphor, a canalised trait is illustrated as a valley (which he called a creode) enclosed by high ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neologism
A neologism Greek νέο- ''néo''(="new") and λόγος /''lógos'' meaning "speech, utterance"] is a relatively recent or isolated term, word, or phrase that may be in the process of entering common use, but that has not been fully accepted into mainstream language. Neologisms are often driven by changes in culture and technology. In the process of language formation, neologisms are more mature than '' protologisms''. A word whose development stage is between that of the protologism (freshly coined) and neologism (new word) is a ''prelogism''. Popular examples of neologisms can be found in science, fiction (notably science fiction), films and television, branding, literature, jargon, cant, linguistics, the visual arts, and popular culture. Former examples include ''laser'' (1960) from Light Amplification by Stimulated Emission of Radiation; ''robot'' (1941) from Czech writer Karel Čapek's play ''R.U.R. (Rossum's Universal Robots)''; and ''agitprop'' (1930) (a portmanteau of " ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sean B
Sean, also spelled Seán or Séan in Irish English, is a male given name of Irish origin. It comes from the Irish versions of the Biblical Hebrew name ''Yohanan'' (), Seán (anglicized as ''Shaun/Shawn/ Shon'') and Séan (Ulster variant; anglicized ''Shane/Shayne''), rendered ''John'' in English and Johannes/Johann/Johan in other Germanic languages. The Norman French ''Jehan'' (see ''Jean'') is another version. For notable people named Sean, refer to List of people named Sean. Origin The name was adopted into the Irish language most likely from ''Jean'', the French variant of the Hebrew name ''Yohanan''. As Gaelic has no letter (derived from ; English also lacked until the late 17th Century, with ''John'' previously been spelt ''Iohn'') so it is substituted by , as was the normal Gaelic practice for adapting Biblical names that contain in other languages (''Sine''/''Siobhàn'' for ''Joan/Jane/Anne/Anna''; ''Seonaid''/''Sinéad'' for ''Janet''; ''Seumas''/''Séamus'' for ''Jam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systems Biology
Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionist, reductionism) to biological research. Particularly from the year 2000 onwards, the concept has been used widely in biology in a variety of contexts. The Human Genome Project is an example of applied systems thinking in biology which has led to new, collaborative ways of working on problems in the biological field of genetics. One of the aims of systems biology is to model and discover emergent property, emergent properties, properties of cell (biology), cells, tissue (biology), tissues and organisms functioning as a system whose theoretical description is only possible using techniques of systems biology. These typically involve metabolic networks or cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Biology
Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and functioning of organisms. Cell biology is the study of structural and functional units of cells. Cell biology encompasses both prokaryotic and eukaryotic cells and has many subtopics which may include the study of cell metabolism, cell communication, cell cycle, biochemistry, and cell composition. The study of cells is performed using several microscopy techniques, cell culture, and cell fractionation. These have allowed for and are currently being used for discoveries and research pertaining to how cells function, ultimately giving insight into understanding larger organisms. Knowing the components of cells and how cells work is fundamental to all biological sciences while also being essential for research in biomedical fields such as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Nature Of Order
''The Nature of Order: An Essay on the Art of Building and the Nature of the Universe'' () is a four-volume work by the architect Christopher Alexander published in 2002–2004. In his earlier work, Alexander attempted to formulate the principles that lead to a good built environment as patterns, or recurring design solutions. However, he came to believe that patterns themselves are not enough to generate life in buildings and cities, and that one needs a "morphogenetic" understanding of the formation of the built environment as well as a deep understanding of how the makers get in touch with the creative process. ''The Phenomenon of Life'' Volume 1 attempts to define "life" in the built environment and determine why one built environment may have more life than another. Important to this idea is his notion of ''centers'': :"Centers are those particular identified sets, or systems, which appear within the larger whole as distinct and noticeable parts. They appear because they have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Configuration Space (physics)
In classical mechanics, the parameters that define the configuration of a system are called ''generalized coordinates,'' and the space defined by these coordinates is called the configuration space of the physical system. It is often the case that these parameters satisfy mathematical constraints, such that the set of actual configurations of the system is a manifold in the space of generalized coordinates. This manifold is called the configuration manifold of the system. Notice that this is a notion of "unrestricted" configuration space, i.e. in which different point particles may occupy the same position. In mathematics, in particular in topology, a notion of "restricted" configuration space is mostly used, in which the diagonals, representing "colliding" particles, are removed. Example: a particle in 3D space The position of a single particle moving in ordinary Euclidean 3-space is defined by the vector q=(x,y,z), and therefore its ''configuration space'' is Q=\mathbb^3. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christopher Alexander
Christopher Wolfgang John Alexander (4 October 1936 – 17 March 2022) was an Austrian-born British-American architect and design theorist. He was an emeritus professor at the University of California, Berkeley. His theories about the nature of human-centered design have affected fields beyond architecture, including urban design, software, and sociology. Alexander designed and personally built over 100 buildings, both as an architect and a general contractor. In software, Alexander is regarded as the father of the pattern language movement. The first wiki—the technology behind Wikipedia—led directly from Alexander's work, according to its creator, Ward Cunningham. Alexander's work has also influenced the development of agile software development. In architecture, Alexander's work is used by a number of different contemporary architectural communities of practice, including the New Urbanist movement, to help people to reclaim control over their own built environment. How ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sanford Kwinter
Sanford Kwinter is a Canadian-born, New York-based writer and architectural theorist, and a co-founder of Zone Books publishers. Kwinter currently serves as Professor of Theory and Criticism at the Pratt Institute. He formerly served as an associate professor at Rice University in Houston, Texas, and has also taught at MIT, Columbia University and Cornell University and at Harvard University Graduate School of Design. Having received a doctorate in comparative literature from Columbia University, Kwinter lectured at Harvard University, the University of Applied Arts Vienna (''Universität für angewandte Kunst Wien''), the Berlage Institute in Rotterdam, the Architectural Association in London and the Städelschule The Städelschule (), Staatliche Hochschule für Bildende Künste, is a tertiary school of art in Frankfurt am Main, Germany. It accepts about 20 students each year from 500 applicants, and has a total of approximately 150 students of visual a ... in Frankfurt. Ov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sean B Carroll
Sean B. Carroll (born September 17, 1960) is an American evolutionary developmental biologist, author, educator and executive producer. He is a distinguished university professor at the University of Maryland and professor emeritus of molecular biology and genetics at the University of Wisconsin–Madison. His studies focus on the evolution of cis-regulatory elements in the regulation of gene expression in the context of biological development, using ''Drosophila'' as a model system. He is a member of the National Academy of Sciences, of the American Philosophical Society (2007), of the American Academy of Arts and Sciences and the American Association for Advancement of Science. He is a Howard Hughes Medical Institute investigator. Carroll has received the Shaw Scientist Award from the Greater Milwaukee Foundation, the Stephen Jay Gould Prize from the Society for the Study of Evolution, the Benjamin Franklin Medal in Life Science, and the Lewis Thomas Prize at Rockefeller U ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evolutionary Developmental Biology
Evolutionary developmental biology (informally, evo-devo) is a field of biological research that compares the developmental processes of different organisms to infer how developmental processes evolved. The field grew from 19th-century beginnings, where embryology faced a mystery: zoologists did not know how embryonic development was controlled at the molecular level. Charles Darwin noted that having similar embryos implied common ancestry, but little progress was made until the 1970s. Then, recombinant DNA technology at last brought embryology together with molecular genetics. A key early discovery was of homeotic genes that regulate development in a wide range of eukaryotes. The field is composed of multiple core evolutionary concepts. One is deep homology, the finding that dissimilar organs such as the eyes of insects, vertebrates and cephalopod molluscs, long thought to have evolved separately, are controlled by similar genes such as ''pax-6'', from the evo-devo gene toolk ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Portmanteau
A portmanteau word, or portmanteau (, ) is a blend of wordsGarner's Modern American Usage , p. 644. in which parts of multiple words are combined into a new word, as in ''smog'', coined by blending ''smoke'' and ''fog'', or ''motel'', from ''motor'' and ''hotel''. In , a portmanteau is a single morph that is analyzed as representing two (or more) underlying s. When portmanteaus shorten es ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
