Contraindicate
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Contraindicate
In medicine, a contraindication is a condition that serves as a reason not to take a certain medical treatment due to the harm that it would cause the patient. Contraindication is the opposite of indication, which is a reason to use a certain treatment. ''Absolute contraindications'' are contraindications for which there are no reasonable circumstances for undertaking a course of action. For example, children and teenagers with viral infections should not be given aspirin because of the risk of Reye syndrome, and a person with an anaphylactic food allergy should never eat the food to which they are allergic. Similarly, a person with hemochromatosis should not be administered iron preparations. ''Relative contraindications'' are contraindications for circumstances in which the patient is at higher risk of complications from treatment, but these risks may be outweighed by other considerations or mitigated by other measures. For example, a pregnant woman should normally avoid gett ...
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Isotretinoin
Isotretinoin, also known as 13-''cis''-retinoic acid and sold under the brand name Accutane among others, is a medication primarily used to treat severe acne. It is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug. The most common adverse effects are dry lips ( cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include muscle aches and pains (myalgias), and headaches. Isotretinoin is known to cause birth defects due to in-utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative that controls normal embryonic development. It is also associated with psychiatri ...
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Aspirin
Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. For pain or fever, effects typically begin within 30 minutes. Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. One common adverse effect is an upset stomach. More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. Bleeding risk is greater among those who are older, drink alcohol, take other NSAIDs, or are on other blood thinners. Aspirin is not recommended in the last part of pregnancy. It is not generally recommended in children with infections because of the risk of ...
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Medicine
Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others. Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of skill and knowledge), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, o ...
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Tuberculosis
Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in which case it is known as latent tuberculosis. Around 10% of latent infections progress to active disease which, if left untreated, kill about half of those affected. Typical symptoms of active TB are chronic cough with blood-containing mucus, fever, night sweats, and weight loss. It was historically referred to as consumption due to the weight loss associated with the disease. Infection of other organs can cause a wide range of symptoms. Tuberculosis is spread from one person to the next through the air when people who have active TB in their lungs cough, spit, speak, or sneeze. People with Latent TB do not spread the disease. Active infection occurs more often in people with HIV/AIDS and in those who smoke. Diagnosis of active TB is ...
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Drug Reaction Testing
Drug reaction testing uses a genetic test to predict how a particular person will respond to various prescription and non-prescription medications. It checks for genes that code for specific liver enzymes which activate, deactivate, or are influenced by various drugs. There are currently four genetic markers commonly tested for: 2D6, 2C9, 2C19, and 1A2. This testing has been done for some time by drug companies working on new drugs, but is relatively newly available to the general public. Strattera is the first drug to mention the test in the official documentation, although it doesn't specifically recommend that patients get the test before taking the medication. There are four possible categories for each marker: poor metabolizer, intermediate metabolizer, extensive metabolizer, or ultra-extensive metabolizer. Different testing companies may call these by different names. Extensive metabolizers (that is, people who are extensive metabolizers of a given type) are the mos ...
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Classification Of Pharmaco-Therapeutic Referrals
The ''Classification of Pharmaco-Therapeutic Referrals'' (''CPR'') is a taxonomy focused on defining and grouping together situations requiring a referral from pharmacists to physicians (and vice versa) regarding the pharmacotherapy used by the patients. It has been published in 2008. It is bilingual: English/Spanish (''Clasificación de Derivaciones Fármaco-terapéuticas''). It is a simple and efficient classification of pharmaco-therapeutic referrals between physicians and pharmacists permitting a common inter-professional language. It is adapted to any type of referrals among health professionals, and to increase its specificity it can be combined with ATC codes, ICD-10, and ICPC-2 PLUS. It is a part of the ''MEDAFAR Project'', whose objective is to improve, through different scientific activities, the coordination processes between physicians and pharmacists working in primary health care. Supporting institutions * Pharmaceutical Care Foundation of Spain (''Fundación P ...
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Word-sense Disambiguation
Word-sense disambiguation (WSD) is the process of identifying which sense of a word is meant in a sentence or other segment of context. In human language processing and cognition, it is usually subconscious/automatic but can often come to conscious attention when ambiguity impairs clarity of communication, given the pervasive polysemy in natural language. In computational linguistics, it is an open problem that affects other computer-related writing, such as discourse, improving relevance of search engines, anaphora resolution, coherence, and inference. Given that natural language requires reflection of neurological reality, as shaped by the abilities provided by the brain's neural networks, computer science has had a long-term challenge in developing the ability in computers to do natural language processing and machine learning. Many techniques have been researched, including dictionary-based methods that use the knowledge encoded in lexical resources, supervised machine le ...
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Word Sense
In linguistics, a word sense is one of the meanings of a word. For example, a dictionary may have over 50 different senses of the word "play", each of these having a different meaning based on the context of the word's usage in a sentence, as follows: In each sentence different collocates of "play" signal its different meanings. People and computers, as they read words, must use a process called word-sense disambiguationR. Navigli''Word Sense Disambiguation: A Survey', ACM Computing Surveys, 41(2), 2009, pp. 1-69. to reconstruct the likely intended meaning of a word. This process uses context to narrow the possible senses down to the probable ones. The context includes such things as the ideas conveyed by adjacent words and nearby phrases, the known or probable purpose and register of the conversation or document, and the orientation (time and place) implied or expressed. The disambiguation is thus context-sensitive. Advanced semantic analysis has resulted in a sub-di ...
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Usage (language)
The usage of a language is the ways in which its written and spoken variations are routinely employed by its speakers; that is, it refers to "the collective habits of a language's native speakers", as opposed to idealized models of how a language works or (should work) in the abstract. For instance, Fowler characterized usage as "the way in which a word or phrase is normally and correctly used" and as the "points of grammar, syntax, style, and the choice of words." In the descriptive tradition of language analysis, by way of contrast, "correct" tends to mean functionally adequate for the purposes of the speaker or writer using it, and adequately idiomatic to be accepted by the listener or reader; usage is also, however, a concern for the prescriptive tradition, for which "correctness" is a matter of arbitrating style. Common usage may be used as one of the criteria of laying out prescriptive norms for codified standard language usage. Modern dictionaries are not generally p ...
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Centers For Disease Control And Prevention
The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency, under the Department of Health and Human Services, and is headquartered in Atlanta, Georgia. The agency's main goal is the protection of public health and safety through the control and prevention of disease, injury, and disability in the US and worldwide. The CDC focuses national attention on developing and applying disease control and prevention. It especially focuses its attention on infectious disease, food borne pathogens, environmental health, occupational safety and health, health promotion, injury prevention and educational activities designed to improve the health of United States citizens. The CDC also conducts research and provides information on non-infectious diseases, such as obesity and diabetes, and is a founding member of the International Association of National Public Health Institutes.
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British National Formulary
The ''British National Formulary'' (BNF) is a United Kingdom (UK) pharmaceutical reference book that contains a wide spectrum of information and advice on prescribing and pharmacology, along with specific facts and details about many medicines available on the UK National Health Service (NHS). Information within the BNF includes indication(s), contraindications, side effects, doses, legal classification, names and prices of available proprietary and generic formulations, and any other notable points. Though it is a national formulary, it nevertheless also includes entries for some medicines which are not available under the NHS, and must be prescribed and/or purchased privately. A symbol clearly denotes such drugs in their entry. It is used by pharmacists and doctors (both general practitioners (GPs) and specialist practitioners), and by other prescribing healthcare professionals (such as nurses, pharmacy technicians, paramedics, and dentists); as a reference for corr ...
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Style Guide
A style guide or manual of style is a set of standards for the writing, formatting, and design of documents. It is often called a style sheet, although that term also has multiple other meanings. The standards can be applied either for general use, or be required usage for an individual publication, a particular organization, or a specific field. A style guide establishes standard style requirements to improve communication by ensuring consistency both within a document, and across multiple documents. Because practices vary, a style guide may set out standards to be used in areas such as punctuation, capitalization, citing sources, formatting of numbers and dates, table appearance and other areas. The style guide may require certain best practices in writing style, usage, language composition, visual composition, orthography, and typography. For academic and technical documents, a guide may also enforce the best practice in ethics (such as authorship, research ethics, and ...
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