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Coclaurine
Coclaurine is a nicotinic acetylcholine receptor antagonist which has been isolated from a variety of plant sources including ''Nelumbo nucifera'', '' Sarcopetalum harveyanum'', '' Ocotea duckei'', and others. It belongs to the class of tetrahydroisoquinoline alkaloid Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...s. Dimerization of coclaurine leads to the biscoclaurine alkaloids such as cepharanthine. References Nicotinic antagonists Benzylisoquinoline alkaloids Phenols {{alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzylisoquinoline Alkaloids
Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, the most widely examined of the numerous benzylisoquinoline structural isomers. The 1-benzylisoquinoline moiety can be identified within numerous compounds of pharmaceutical interest, such as moxaverine; but most notably it is found within the structures of a wide variety of plant natural products, collectively referred to as benzylisoquinoline alkaloids. This class is exemplified in part by the following compounds: papaverine, noscapine, codeine, morphine, apomorphine, berberine, tubocurarine. Biosynthesis (''S'')- Norcoclaurine (higenamine) has been identified as the central 1-benzyl-tetrahydro-isoquinoline precursor from which numerous complex biosynthetic pathways eventually emerge. These pathways collectively lead to the structurally disparate compounds comprising the broad classification of plant natural products referred to as benzylisoquinoline alkaloids (B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nelumbo Nucifera
''Nelumbo nucifera'', also known as sacred lotus, Laxmi lotus, Indian lotus, or simply lotus, is one of two extant species of aquatic plant in the family Nelumbonaceae. It is sometimes colloquially called a water lily, though this more often refers to members of the family Nymphaeaceae. Lotus plants are adapted to grow in the flood plains of slow-moving rivers and delta areas. Stands of lotus drop hundreds of thousands of seeds every year to the bottom of the pond. While some sprout immediately, and most are eaten by wildlife, the remaining seeds can remain dormant for an extensive period of time as the pond silts in and dries out. During flood conditions, sediments containing these seeds are broken open, and the dormant seeds rehydrate and begin a new lotus colony. Under favorable circumstances, the seeds of this aquatic perennial may remain viable for many years, with the oldest recorded lotus germination being from seeds 1,300 years old recovered from a dry lakebed in n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cepharanthine
Cepharanthine is an antiinflammatory and antineoplastic compound isolated from ''Stephania''. Due to these modalities, it has been shown effective against HTLV The human T-lymphotropic virus, human T-cell lymphotropic virus, or human T-cell leukemia-lymphoma virus (HTLV) family of viruses are a group of human retroviruses that are known to cause a type of cancer called adult T-cell leukemia/lymphoma an ... in lab research. Additionally, it has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported. References Benzylisoquinoline alkaloids Anti-inflammatory agents {{antineoplastic-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms. At the neuromuscular junction they are the primary receptor in muscle for motor nerve-muscle communication that controls muscle contraction. In the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the sympathetic and parasympathetic nervous system, and (2) they are the receptors found on skeletal muscle that receive acetylcholine released to signal for muscular contraction. In the immune system, nAChRs regulate inflammatory processes and signal through distinct intracellular pathways. In insects, the cholinergic system is limited to the central nervous system. The nicotinic receptors are considered cholinergi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor Antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist drugs interfere in the natural operation of receptor proteins.Pharmacology Guide: In vitro pharmacology: concentration-response curves " '' GlaxoWellcome.'' Retrieved on December 6, 2007. They are sometimes called blockers; examples include alpha blockers, |
Sarcopetalum Harveyanum
''Sarcopetalum harveyanum'', known as the pearl vine, is a common plant found mostly in coastal areas of eastern Australia. It can be found in or around rainforests, and is also seen in eucalyptus forests. The leaf stalk is attached under the surface of the leaf. The leaves are heart shaped with raised leaf veins on both surfaces of the leaf. Seven veins branch out from the leaf base (A mid rib and three pairs of veins). The inner pair of veins extend almost all the way up the leaf. Leaves are 4 to 12 cm long and 2 to 9 cm wide. The leaf stem is 1 to 8 cm long. The swelling at the base of the leaf stem is enlarged and evident. Red or yellow flowers occur on racemes in summer. These racemes often grow from old wood on the vine. The flowers are tiny and seldom seen, petals 3 mm long. The fruit is a red drupe In botany, a drupe (or stone fruit) is an indehiscent fruit in which an outer fleshy part (exocarp, or skin, and mesocarp, or flesh) surrounds a sin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lloydia
''Gagea'' is a large genus of spring flowers in the lily family. It is found primarily in Eurasia with a few species extending into North Africa and one species (''Gagea serotina'') in North America. The genus is named after the English naturalist Sir Thomas Gage (1791-1820). They were originally described as species of ''Ornithogalum'', which, together with the usual yellow colour of the flowers, explains the English name yellow star-of-Bethlehem for the common European species, ''Gagea lutea''. p. 25. Species , the World Checklist of Selected Plant Families The World Checklist of Selected Plant Families (usually abbreviated to WCSP) is an "international collaborative programme that provides the latest peer reviewed and published opinions on the accepted scientific names and synonyms of selected plan ... recognizes over 200 species, including those previously assigned to ''Lloydia''. References Bibliography * * External links Pacific Bulb Societyphotos of severa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ocotea Duckei
''Ocotea'' is a genus of flowering plants belonging to the family Lauraceae. Many are evergreen trees with lauroid leaves. There are over 520 species currently accepted within the genus, distributed mostly in tropical and subtropical areas of the Americas (around 300 species) including the Caribbean and West Indies, but also with some species in Africa, Madagascar and the Mascarene Islands. One species (''O. foetens'') is native to the Macaronesia (in Canary Islands and Madeira). The genus is suspected to be paraphyletic. Description They are trees or shrubs, occasionally with adventitious roots (''O. hartshorniana'', ''O. insularis''). Leaves simple, alternate, rarely opposite or whorled. The leaves are lauroid, they are commonly dark green glossy with sometimes brown on the underside and fragrant oil cells. The African and Madagascan species all have bisexual flowers (possessing both male and female parts), whereas many of the American species have flowers that a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrahydroisoquinoline
Tetrahydroisoquinoline (TIQ or THIQ) is an organic compound with the chemical formula C9H11N. Classified as a secondary amine, it is derived from isoquinoline by hydrogenation. It is a colorless viscous liquid that is miscible with most organic solvents. The tetrahydroisoquinoline skeleton is encountered in a number of bioactive compounds and drugs. Reactions As a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids. It can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide. Toxicology Tetrahydroisoquinoline derivatives may be formed in the body as metabolites of some drugs, and this was once thought to be involved in the development of alcoholism. This theory has now been discredited and is no longer generally accepted by the scientific community, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dimer (chemistry)
A dimer () ('' di-'', "two" + ''-mer'', "parts") is an oligomer consisting of two monomers joined by bonds that can be either strong or weak, covalent or intermolecular. Dimers also have significant implications in polymer chemistry, inorganic chemistry, and biochemistry. The term ''homodimer'' is used when the two molecules are identical (e.g. A–A) and ''heterodimer'' when they are not (e.g. A–B). The reverse of dimerization is often called dissociation. When two oppositely charged ions associate into dimers, they are referred to as ''Bjerrum pairs'', after Niels Bjerrum. Noncovalent dimers Anhydrous carboxylic acids form dimers by hydrogen bonding of the acidic hydrogen and the carbonyl oxygen. For example, acetic acid forms a dimer in the gas phase, where the monomer units are held together by hydrogen bonds. Under special conditions, most OH-containing molecules form dimers, e.g. the water dimer. Excimers and exciplexes are excited structures with a short lifetime. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicotinic Antagonists
A nicotinic antagonist is a type of anticholinergic drug that inhibits the action of acetylcholine (ACh) at nicotinic acetylcholine receptors. These compounds are mainly used for peripheral muscle paralysis in surgery, the classical agent of this type being tubocurarine,P. Taylor (1990). In ''Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th Ed.'', (A. G. Gilman et al., Eds.), pp. 166-186, New York: Pergamon Press. but some centrally acting compounds such as bupropion, mecamylamine, and 18-methoxycoronaridine block nicotinic acetylcholine receptors in the brain and have been proposed for treating nicotine addiction. *Note: Succinylcholine is a nicotinic agonist. See neuromuscular blocking agents page for details on the mechanism of action. See also * Nicotinic acetylcholine receptor * Nicotinic agonist * Muscarinic acetylcholine receptor * Muscarinic agonist * Muscarinic antagonist A muscarinic receptor antagonist (MRA) is a type of anticholinergic agent t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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