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Clinical Effectiveness
Efficacy is the ability to perform a task to a satisfactory or expected degree. The word comes from the same roots as ''effectiveness'', and it has often been used synonymously, although in pharmacology a distinction is now often made between efficacy and effectiveness. The word ''efficacy'' is used in pharmacology and medicine to refer both to the maximum response achievable from a pharmaceutical drug in research settings, and to the capacity for sufficient therapeutic effect or beneficial change in clinical settings. Pharmacology In pharmacology, efficacy () is the maximum response achievable from an applied or dosed agent, for instance, a small molecule drug. Intrinsic activity is a relative term for a drug's efficacy relative to a drug with the highest observed efficacy. It is a purely descriptive term that has little or no mechanistic interpretation. In order for a drug to have an effect, it needs to bind to its target, and then to affect the function of this target. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacology
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word ''pharmacon'' is used as a term to encompass these endogenous and exogenous bioactive species). More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties,functions,sources,synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabilities. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calvinist
Calvinism (also called the Reformed Tradition, Reformed Protestantism, Reformed Christianity, or simply Reformed) is a major branch of Protestantism that follows the theological tradition and forms of Christian practice set down by John Calvin and other Reformation-era theologians. It emphasizes the sovereignty of God and the authority of the Bible. Calvinists broke from the Roman Catholic Church in the 16th century. Calvinists differ from Lutherans (another major branch of the Reformation) on the spiritual real presence of Christ in the Lord's Supper, theories of worship, the purpose and meaning of baptism, and the use of God's law for believers, among other points. The label ''Calvinism'' can be misleading, because the religious tradition it denotes has always been diverse, with a wide range of influences rather than a single founder; however, almost all of them drew heavily from the writings of Augustine of Hippo twelve hundred years prior to the Reformation. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Placebo (origins Of Technical Term)
A placebo ( ) is a substance or treatment which is designed to have no therapeutic value. Common placebos include inert tablets (like sugar pills), inert injections (like saline), sham surgery, and other procedures. In general, placebos can affect how patients perceive their condition and encourage the body's chemical processes for relieving pain and a few other symptoms, but have no impact on the disease itself. Improvements that patients experience after being treated with a placebo can also be due to unrelated factors, such as regression to the mean (a statistical effect where an unusually high or low measurement is likely to be followed by a less extreme one). The use of placebos in clinical medicine raises ethical concerns, especially if they are disguised as an active treatment, as this introduces dishonesty into the doctor–patient relationship and bypasses informed consent. While it was once assumed that this deception was necessary for placebos to have any effect, ther ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Efficiency (other)
Efficiency is the extent to which time or effort is well used for the intended task or purpose. Efficiency may also refer to: * Efficiency (aerodynamics), the amount of lift divided by the aerodynamic drag * Efficiency (apartment), a one-room apartment * Efficiency (basketball), a statistical benchmark to compare the overall value of players * Efficiency (economics), a situation in which nothing can be improved without something else being hurt ** Efficiency (fair division), any changes made to assist one person would harm another * Efficiency (finance), non-mean-variance portfolio analysis, a way of showing that a portfolio is not efficient * Efficiency (mechanical) * Efficiency (network science), a measure of how efficiently a network exchanges information * Efficiency (statistics), a measure of quality of an estimator, experiment, or test * Energy efficiency (physics), the ratio of power consumed to useful power output See also * Efficient (horse) (foaled 2003), a New Zeala ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Average Treatment Effect
The average treatment effect (ATE) is a measure used to compare treatments (or interventions) in randomized experiments, evaluation of policy interventions, and medical trials. The ATE measures the difference in mean (average) outcomes between units assigned to the treatment and units assigned to the control. In a randomized trial (i.e., an experimental study), the average treatment effect can be estimated from a sample using a comparison in mean outcomes for treated and untreated units. However, the ATE is generally understood as a causal parameter (i.e., an estimate or property of a population) that a researcher desires to know, defined without reference to the study design or estimation procedure. Both observational studies and experimental study designs with random assignment may enable one to estimate an ATE in a variety of ways. General definition Originating from early statistical analysis in the fields of agriculture and medicine, the term "treatment" is now applied, more ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Law And Gospel
In Protestant Christianity, the relationship between Law and Gospel— God's Law and the Gospel of Jesus Christ—is a major topic in Lutheran and Reformed theology. In these religious traditions, the distinction between the doctrines of Law, which demands obedience to God's ethical will, and Gospel, which promises the forgiveness of sins in light of the person and work of Jesus Christ, is critical. Ministers use it as a hermeneutical principle of biblical interpretation and as a guiding principle in homiletics (sermon composition) and pastoral care. It involves the supersession of the Old Covenant (including traditional Jewish law, or halakha) by the New Covenant and Christian theology. Other Christian groups have a view on the issue as well, or more generally views of the Old Covenant, though the matter has not usually been as hotly debated or rigorously defined as in the Lutheran and Reformed traditions. Sometimes the issue is discussed under the headings of "Law ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Good News (Christianity)
The gospel or good news is a theological concept in several religions. In the historical Roman imperial cult and today in Christianity, the gospel is a message about salvation by a divine figure, a savior, who has brought peace or other benefits to humankind. In Ancient Greek religion, the word designated a type of sacrifice or ritual dedication intended to thank the gods upon receiving good news. The religious concept dates back at least as far as Greece's Classical era. Roman authors are known to have adopted it toward the end of the 1st century BCE, and Christians somewhat later. It is a central message of Christianity today, in which written accounts of the life and teaching of Jesus Christ are known as Gospels. Etymology ''Gospel'' () is the Old English translation of Greek , meaning "good news". This may be seen from analysis of ( grc, εὖ, eû, "good", label=none + grc, ἄγγελος, ángelos, "messenger", label=none + grc, -ιον, -ion, label=none diminutive suf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Original Sin
Original sin is the Christian doctrine that holds that humans, through the fact of birth, inherit a tainted nature in need of regeneration and a proclivity to sinful conduct. The biblical basis for the belief is generally found in Genesis 3 (the story of the expulsion of Adam and Eve from the Garden of Eden), in a line in Psalm 51:5 ("I was brought forth in iniquity, and in sin did my mother conceive me"), and in Paul's Epistle to the Romans, 5:12-21 ("Therefore, just as sin entered the world through one man, and death through sin, and in this way death came to all people, because all sinned"). The belief began to emerge in the 3rd century, but only became fully formed with the writings of Augustine of Hippo (354–430), who was the first author to use the phrase "original sin" ( la, peccatum originale). Influenced by Augustine, the councils of Carthage (411–418 AD) and Orange (529 AD) brought theological speculation about original sin into the official lexicon of the Church. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Irresistible Grace
Irresistible grace (also called effectual grace, effectual calling, or efficacious grace) is a doctrine in Christian theology particularly associated with Calvinism, which teaches that the saving grace of God is effectually applied to those whom he has determined to save (the elect) and, in God's timing, overcomes their resistance to obeying the call of the gospel, bringing them to faith in Christ. It is to be distinguished from prevenient grace, particularly associated with Arminianism, which teaches that the offer of salvation through grace does not act irresistibly in a purely cause-effect, deterministic method, but rather in an influence-and-response fashion that can be both freely accepted and freely denied. The doctrine Some claim that fourth-century Church Father Augustine of Hippo taught that God grants those whom he chooses for salvation the gift of persevering grace, and that they could not conceivably fall away. This doctrine gave rise to the doctrine of irresisti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Formula Of Concord
Formula of Concord (1577) (German, ''Konkordienformel''; Latin, ''Formula concordiae''; also the "''Bergic Book''" or the "''Bergen Book''") is an authoritative Lutheran statement of faith (called a confession, creed, or "symbol") that, in its two parts (''Epitome'' and ''Solid Declaration''), makes up the final section of the Lutheran ''Corpus Doctrinae'' or Body of Doctrine, known as the Book of Concord (most references to these texts are to the original edition of 1580). The ''Epitome'' is a brief and concise presentation of the ''Formula's'' twelve articles; the ''Solid Declaration'' a detailed exposition. Approved doctrine is presented in "theses"; rejected doctrine in "antitheses." As the original document was written in German, a Latin translation was prepared for the Latin edition of the Book of Concord published in 1584. Significance and composition The promulgation and subscription of this document was a major factor in the unification and preservation of Lutheranism ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Means Of Grace
The means of grace in Christian theology are those things (the ''means'') through which God gives grace. Just what this grace entails is interpreted in various ways: generally speaking, some see it as God blessing humankind so as to sustain and empower the Christian life; others see it as forgiveness, life, and salvation. Catholic theology According to the Catholic Church, the means of grace that Christ entrusted to the Church are many.Catholic Bishops' Conferences of England & Wales, Ireland and Scotland, ''One Bread One Body'' , p. 7 They include the entirety of revealed truth, the and the hierarchical ministry. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Smalcald Articles
The Smalcald Articles or Schmalkald Articles (german: Schmalkaldische Artikel) are a summary of Lutheran doctrine, written by Martin Luther in 1537 for a meeting of the Schmalkaldic League in preparation for an intended ecumenical Council of the Church. History Luther's patron, Elector John Frederick of Saxony, asked him to prepare these articles for the Schmalkaldic League's meeting in 1537, held again in Schmalkalden. The League had been organized in 1531 as a union of various Lutheran territories and cities, to provide a united military and political front against Roman Catholic politicians and armies, led by Emperor Charles V. When the Schmalkaldic League met, Luther was taken very ill with a severe case of kidney stones and so was unable to attend the meeting. The league ultimately determined not to adopt the articles Luther had written. They were influenced not to adopt the Smalcald Articles by Philipp Melanchthon, who was concerned that Luther's writing would be regarded ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
