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Chondroitinase
Chondroitinase may refer to: * N-acetylgalactosamine-4-sulfatase, an enzyme * N-acetylgalactosamine-6-sulfatase, an enzyme * Chondroitin ABC lyase, an enzyme {{Short pages monitor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-acetylgalactosamine-4-sulfatase
''N''-acetylgalactosamine-4-sulfatase (EC 3.1.6.12, chondroitinsulfatase, chondroitinase, arylsulfatase B, acetylgalactosamine 4-sulfatase, ''N''-acetylgalactosamine 4-sulfate sulfohydrolase) is an enzyme with systematic name ''N''-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase. It catalyses the following reaction: : Hydrolysis of the 4-sulfate groups of the ''N''-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. It also acts on ''N''-acetylglucosamine 4-sulfate. See also * Arylsulfatase B Arylsulfatase B (N-acetylgalactosamine-4-sulfatase, chondroitinsulfatase, chondroitinase, acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase, ) is an enzyme associated with mucopolysaccharidosis VI (Maroteaux–L ... References External links * {{Portal bar, Biology, border=no EC 3.1.6 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-acetylgalactosamine-6-sulfatase
The enzyme ''N''-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) catalyzes the chemical reaction of cleaving off the 6-sulfate groups of the ''N''-acetyl-D-galactosamine 6-sulfate units of the macromolecule chondroitin sulfate and, similarly, of the D-galactose 6-sulfate units of the macromolecule keratan sulfate. This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is ''N''-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase. Other names in common use include chondroitin sulfatase, chondroitinase, galactose-6-sulfate sulfatase, acetylgalactosamine 6-sulfatase, ''N''-acetylgalactosamine-6-sulfate sulfatase, and ''N''-acetylgalactosamine 6-sulfatase. This enzyme participates in glycosaminoglycan degradation and degradation of glycan structures. Deficiency Morquio syndrome is a rare birth defect caused by a deficiency in this essential enzyme. Treatment options include enzyme replacement therapy with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |