Cholecystography
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Cholecystography
Oral cholecystography is a radiological procedure used to visualize the gallbladder and biliary channels, developed in 1924 by American surgeons Evarts Ambrose Graham Evarts Ambrose Graham (1883–1957) was an American academic, physician, and surgeon. Early years and military service Born in Chicago, Illinois to a surgeon, Dr. David Wilson Graham, and Ida Ansbach Barned Graham, Evarts attended college at Prin ... and Warren Henry Cole. It is usually indicated in cases of suspected gallbladder disease, and can also be used to determine or rule out the presence of intermittent obstruction of the bile ducts or recurrent biliary disease after biliary surgery. A radiopaque cholegraphic (contrast) agent, usually iopanoic acid (Telepaque) or its sodium or calcium salt, is orally administered, which is absorbed by the intestine. This excreted material will collect in the gallbladder, where reabsorption of water concentrates the excreted contrast. Since only 10% of gallstones are ra ...
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Gallbladder
In vertebrates, the gallbladder, also known as the cholecyst, is a small hollow organ where bile is stored and concentrated before it is released into the small intestine. In humans, the pear-shaped gallbladder lies beneath the liver, although the structure and position of the gallbladder can vary significantly among animal species. It receives and stores bile, produced by the liver, via the common hepatic duct, and releases it via the common bile duct into the duodenum, where the bile helps in the digestion of fats. The gallbladder can be affected by gallstones, formed by material that cannot be dissolved – usually cholesterol or bilirubin, a product of haemoglobin breakdown. These may cause significant pain, particularly in the upper-right corner of the abdomen, and are often treated with removal of the gallbladder (called a cholecystectomy). Cholecystitis, inflammation of the gallbladder, has a wide range of causes, including result from the impaction of gallstones, inf ...
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Evarts Ambrose Graham
Evarts Ambrose Graham (1883–1957) was an American academic, physician, and surgeon. Early years and military service Born in Chicago, Illinois to a surgeon, Dr. David Wilson Graham, and Ida Ansbach Barned Graham, Evarts attended college at Princeton University (A.B., 1904) and received his M.D. degree from Rush Medical College in 1907. Graham then trained as a surgery resident at Presbyterian Hospital in Chicago, and subsequently as a graduate student in chemistry at the University of Chicago. There, he met his wife, Helen Tredway, Ph.D. (1890-1971), a biochemist and pharmacologist. Evarts served as a Major (O4) in the U.S. Army Medical Corps from 1917 to 1919, and was initially posted to Camp Lee (now Fort Lee, Virginia). He completed revolutionary new work on surgical technique for the treatment of empyema, which had become important following the influenza pandemic of 1918. Afterwards, Dr. Graham served in France as commander of U.S. Army Evacuation Hospital 34. Career a ...
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Warren Henry Cole
Warren Henry Cole (24 July 1898 – 25 May 1990) was an American surgeon, a pioneer in the field of adjunctive treatments for surgical cancer patients. With Evarts Ambrose Graham he co-developed in 1924 the process of visualizing the gall bladder with X-rays by using contrast media, a process used in the diagnosis of gall bladder disease, in 1924. Born in Clay Center, Kansas in 1898 Cole received his M.D. from Washington University School of Medicine, and served on the faculty for several years. Cole left Washington University in 1936 to serve as a professor at University of Illinois Chicago a position he held for 30 years. He served as president of the American Cancer Society The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more than ... from 1959–1960. References External links American C ...
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Iopanoic Acid
Iopanoic acid is an iodine-containing radiocontrast medium used in cholecystography. Both iopanoic acid and ipodate sodium are potent inhibitors of thyroid hormone release from thyroid gland, as well as of peripheral conversion of thyroxine (T4) to triiodothyronine (T3). These compounds inhibit 5'deiodinase (5'DID-1 and 5'DID-2) enzymes, which catalyse T4-T3 conversion in the thyroid cell, liver, kidney, skeletal muscle, heart, brain, pituitary. This accounts for the dramatic improvement in both subjective and objective symptoms of hyperthyroidism, particularly when they are used as an adjunctive therapy with thioamides ( propylthiouracil, carbimazole). They can be used in the treatment of patients with severe thyrotoxicosis (thyroid storm) and significant morbidity (e.g., myocardial infarction A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to the coronary artery of the heart, causing damage to the heart muscle. T ...
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General Electric
General Electric Company (GE) is an American multinational conglomerate founded in 1892, and incorporated in New York state and headquartered in Boston. The company operated in sectors including healthcare, aviation, power, renewable energy, digital industry, additive manufacturing and venture capital and finance, but has since divested from several areas, now primarily consisting of the first four segments. In 2020, GE ranked among the Fortune 500 as the 33rd largest firm in the United States by gross revenue. In 2011, GE ranked among the Fortune 20 as the 14th most profitable company, but later very severely underperformed the market (by about 75%) as its profitability collapsed. Two employees of GE – Irving Langmuir (1932) and Ivar Giaever (1973) – have been awarded the Nobel Prize. On November 9, 2021, the company announced it would divide itself into three investment-grade public companies. On July 18, 2022, GE unveiled the brand names of the companies it will ...
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