Chalepensin
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Chalepensin
Chalepensin is a chemical compound of the furanocoumarin class. Originally isolated in 1967 from fringed rue (''Ruta chalepensis''), from which it derives its name, it has also been found in other plants of the genus '' Ruta'' including common rue (''Ruta graveolens'') and mountain rue (''Ruta montana''). Chemical properties Chalepensin forms colorless crystalline needles with a melting point of 82-83 °C. Research Chalepensin has been shown to have antifertility effects in female rats. This may be the result of toxic effects chalepensin has on the ovaries. This antifertility effect may provide some scientific evidence in support of the traditional uses of fringed rue and modern use of rue oil (oil from plants of the genus ''Ruta'') in South America as an abortifacient. Chalepensis has also been shown to have antibacterial activity against ''Streptococcus mutans ''Streptococcus mutans'' is a facultatively anaerobic, gram-positive coccus (round bacterium) commonly found i ...
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Ruta Chalepensis
file:Ruta chalepensis Dried fruits Tigray Region Ethiopia.jpg, Dried fruits. ''Ruta chalepensis'' is a species of flowering plant in the Rutaceae family known by the common name fringed rue. It is native to Eurasia and North Africa. It has been found elsewhere as an introduced species. It is a perennial herb growing up to 80 centimeters tall. The leaves are compound, each divided into several segments which are subdivided into smaller leaflets. The inflorescence is a cluster of flowers, each with four or five bright yellow petals with rolled, fringed edges. The fruit is a textured capsule which is divided into pointed lobes. In herbalism, traditional herbal medicine, the plant is used as for a number of ailments, such as fever and inflammation. ''Ruta chalepensis'' is the original source of the chemical compound chalepensin. References External links *Jepson Manual Treatment
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Ruta Graveolens
''Ruta graveolens'', commonly known as rue, common rue or herb-of-grace, is a species of '' Ruta'' grown as an ornamental plant and herb. It is native to the Balkan Peninsula. It is grown throughout the world in gardens, especially for its bluish leaves, and sometimes for its tolerance of hot and dry soil conditions. It is also cultivated as a culinary herb, and to a lesser extent as an insect repellent and incense. Etymology The specific epithet ''graveolens'' refers to the strong-smelling leaves.J. D. Douglas and Merrill C. Tenney Description Rue is a woody, perennial shrub. Its leaves are oblong, blue green and arranged pinnate; they release a strong aroma when they are bruised. The flowers are small with 4 to 5 dull yellow petals in clusters. They bear brown seed capsules when pollinated. Uses Traditional use In the ancient Roman world, the naturalists Pedanius Dioscorides and Pliny the Elder recommended that rue be combined with the poisonous shrub oleander to ...
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Furanocoumarin
The furanocoumarins, or furocoumarins, are a class of organic chemical compounds produced by a variety of plants. Most of the plant species found to contain furanocoumarins belong to a handful of plant families. The families Apiaceae and Rutaceae include the largest numbers of plant species that contain furanocoumarins. The families Moraceae and Fabaceae include a few widely distributed plant species that contain furanocoumarins. Generally furanocoumarins are most abundant in plants that have flowered and in ripe seeds and fruits. (An exception is the common fig where furanocoumarins are found chiefly in the milky sap of the leaves and shoots but not the fruits. Cited in McGovern and Barkley 2000, section&nbsPhytophotodermatitis) During the early stages of plant growth, their presence is not easily detected. Structure The chemical structure of furanocoumarins consists of a furan ring fused with a coumarin. The furan ring may be fused in various ways producing several differen ...
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Ruta
''Ruta'' (commonly known as rue) is a genus of strongly scented evergreen subshrubs, 20–60 cm tall, in the family Rutaceae, native to the Mediterranean region, Macaronesia and southwest Asia. About ten species are accepted in the genus. The most well-known species is ''Ruta graveolens'' (rue or common rue). The leaves are bipinnate or tripinnate, with a feathery appearance, and green to strongly glaucous blue-green in colour. The flowers are yellow, with 4–5 petals, about 1 cm diameter, and borne in cymes. The fruit is a 4–5-lobed capsule, containing numerous seeds. Species , Plants of the World Online accepted ten species: *''Ruta angustifolia'' Pers. *''Ruta chalepensis'' L. *''Ruta corsica'' DC. *''Ruta graveolens'' L. *''Ruta lamarmorae'' Bacch., Brullo & Giusso *''Ruta lindsayi'' Turrill *''Ruta microcarpa'' Svent. *''Ruta montana'' (L.) L. *''Ruta oreojasme'' Webb *''Ruta pinnata'' L.f. Medicinal uses Extracts from rue have been used to treat eyestrain, s ...
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Ruta Montana
''Ruta'' (commonly known as rue) is a genus of strongly scented evergreen subshrubs, 20–60 cm tall, in the family Rutaceae, native to the Mediterranean region, Macaronesia and southwest Asia. About ten species are accepted in the genus. The most well-known species is ''Ruta graveolens'' (rue or common rue). The leaves are bipinnate or tripinnate, with a feathery appearance, and green to strongly glaucous blue-green in colour. The flowers are yellow, with 4–5 petals, about 1 cm diameter, and borne in cymes. The fruit is a 4–5-lobed capsule, containing numerous seeds. Species , Plants of the World Online accepted ten species: *''Ruta angustifolia'' Pers. *''Ruta chalepensis'' L. *''Ruta corsica'' DC. *''Ruta graveolens'' L. *''Ruta lamarmorae'' Bacch., Brullo & Giusso *''Ruta lindsayi'' Turrill *''Ruta microcarpa'' Svent. *''Ruta montana'' (L.) L. *''Ruta oreojasme'' Webb *''Ruta pinnata'' L.f. Medicinal uses Extracts from rue have been used to treat eyestrain, s ...
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Abortifacient
An abortifacient ("that which will cause a miscarriage" from Latin: ''abortus'' "miscarriage" and '' faciens'' "making") is a substance that induces abortion. This is a nonspecific term which may refer to any number of substances or medications, ranging from herbs to prescription medications. Common abortifacients used in performing medical abortions include mifepristone, which is typically used in conjunction with misoprostol in a two-step approach. Synthetic oxytocin, which is routinely used safely during term labor, is also commonly used to induce abortion in the second or third trimester. For thousands of years writers in many parts of the world have described and recommended herbal abortifacients to women who seek to terminate a pregnancy, although their use may carry risks to the health of the woman. Medications Because "abortifacient" is a broad term used to describe a substance's effects on pregnancy, there is a wide range of drugs that can be described as abortifac ...
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Streptococcus Mutans
''Streptococcus mutans'' is a facultatively anaerobic, gram-positive coccus (round bacterium) commonly found in the human oral cavity and is a significant contributor to tooth decay. It is part of the " streptococci" (plural, non-italic lowercase), an informal general name for all species in the genus ''Streptococcus''. The microbe was first described by James Kilian Clarke in 1924. This bacterium, along with the closely related species ''Streptococcus sobrinus'', can cohabit the mouth: Both contribute to oral disease, and the expense of differentiating them in laboratory testing is often not clinically necessary. Therefore, for clinical purposes they are often considered together as a group, called the mutans streptococci (plural, non-italic due to its being an informal group name). This grouping of similar bacteria with similar tropism can also be seen in the viridans streptococci, another group of ''Streptococcus'' species. Ecology ''S. mutans'' is naturally present in the hu ...
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Methicillin-resistant Staphylococcus Aureus
Methicillin-resistant ''Staphylococcus aureus'' (MRSA) is a group of Gram-positive bacteria that are genetically distinct from other strains of ''Staphylococcus aureus''. MRSA is responsible for several difficult-to-treat infections in humans. It caused more than 100,000 deaths attributable to antimicrobial resistance in 2019. MRSA is any strain of ''S. aureus'' that has developed (through natural selection) or acquired (through horizontal gene transfer) a multiple drug resistance to beta-lactam antibiotics. Beta-lactam (β-lactam) antibiotics are a broad-spectrum group that include some penams (penicillin derivatives such as methicillin and oxacillin) and cephems such as the cephalosporins. Strains unable to resist these antibiotics are classified as methicillin-susceptible ''S. aureus'', or MSSA. MRSA is common in hospitals, prisons, and nursing homes, where people with open wounds, invasive devices such as catheters, and weakened immune systems are at greater risk of healt ...
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