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Ceftibuten
Ceftibuten is a third-generation cephalosporin antibiotic. It is an orally administered agent, with two dosage forms, capsule or oral suspension. It is marketed by Pernix Therapeutics under the trade name Cedax. Medical uses Ceftibuten is used to treat acute bacterial exacerbations of Bronchitis#Chronic bronchitis, chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis. It is also indicated for pneumonia, infections of the urinary tract, enteritis, and gastroenteritis. Adverse effects In 3,000 patients, ceftibuten was well tolerated. The most frequent reactions were gastrointestinal and nausea. Susceptibility Ceftibuten is active against ''Haemophilus influenzae'', ''Moraxella catarrhalis'', ''Escherichia coli'', ''Klebsiella pneumoniae'', ''K. oxytoca'', ''Proteus vulgaris'', ''P. mirabilis'', ''P. providence'', ''Salmonella'' sp., ''Shigella'' sp., ''Enterobacter'' sp., and ''Streptococcus'' sp. The following represents minimum inhibitory conc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cephalosporin
The cephalosporins (sg. ) are a class of β-lactam antibiotics originally derived from the fungus ''Acremonium'', which was previously known as ''Cephalosporium''. Together with cephamycins, they constitute a subgroup of β-lactam antibiotics called cephems. Cephalosporins were discovered in 1945, and first sold in 1964. Discovery The aerobic mold which yielded cephalosporin C was found in the sea near a sewage outfall in Su Siccu, by Cagliari harbour in Sardinia, by the Italian pharmacologist Giuseppe Brotzu in July 1945. Structure Cephalosporin contains a 6-membered dihydrothiazine ring. Substitutions at position 3 generally affect pharmacology; substitutions at position 7 affect antibacterial activity, but these cases are not always true. Medical uses Cephalosporins can be indicated for the prophylaxis and treatment of infections caused by bacteria susceptible to this particular form of antibiotic. First-generation cephalosporins are active predominantly against Gram ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
