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Catalytically Perfect Enzyme
A diffusion-limited enzyme catalyses a reaction so efficiently that the rate limiting step is that of substrate diffusion into the active site, or product diffusion out. This is also known as kinetic perfection or catalytic perfection. Since the rate of catalysis of such enzymes is set by the diffusion-controlled reaction, it therefore represents an intrinsic, physical constraint on evolution (a maximum peak height in the fitness landscape). Diffusion limited perfect enzymes are very rare. Most enzymes catalyse their reactions to a rate that is 1,000-10,000 times slower than this limit. This is due to both the chemical limitations of difficult reactions, and the evolutionary limitations that such high reaction rates do not confer any extra fitness. History The theory of diffusion-controlled reaction was originally utilized by R.A. Alberty, Gordon Hammes, and Manfred Eigen to estimate the upper limit of enzyme-substrate reaction. According to their estimation, the upper limit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Activity Distribution Graph
Activity may refer to: * Action (philosophy), in general * Human activity: human behavior, in sociology behavior may refer to all basic human actions, economics may study human economic activities and along with cybernetics and psychology may study their modulation * Recreation, or activities of leisure * The Aristotelian concept of energeia, Latinized as ''actus'' * Activity (UML) An activity in Unified Modeling Language (UML) is a major task that must take place in order to fulfill an operation contract. ThStudent Guide to Object-Oriented Developmentdefines an activity as a sequence of activities that make up a process. Ac ..., a major task in Unified Modeling Language * ''Activity'', the rate of catalytic activity, such as enzyme activity (enzyme assay), in physical chemistry and enzymology * Thermodynamic activity, the effective concentration of a solute for the purposes of mass action * Activity (project management) * radioactive decay#Radioactive decay rates, Activity, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
