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Cystatins
The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below. Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins. Cystatins mainly inhibit peptidase enzymes (another term for ''proteases'') belonging to peptidase families C1 (papain family) and C13 ( legumain family). They are known to mis-fold to form amyloid deposits and are implicated in several diseases. Types The cystatin family includes: * The Type 1 cystatins, which are intracellular and are present in the cytosol of many cell types, but can also appear in body fluids at significant concentrations. They are single-chain polypeptides of about 100 residues, which have neither disulfide bonds nor carbohydrate side-chains. Type 1 cystatins are also known as Stefins (after the Stefan Institute where t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CST6 (gene)
Cystatin-M is a protein that in humans is encoded by the ''CST6'' gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. References External links * The MEROPS MEROPS is an online database for peptidases (also known as proteases, proteinases and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ornithodoros
''Ornithodoros'' is a genus in the soft-bodied tick family, Argasidae. Physiology The opening between the midgut and hindgut has been lost, making the ticks unable to pass digestive waste products out of their bodies. Taxonomy The Linnean name derives from ''ornithos'' ( gr, ὄρνιθος) and ''doros'' ( gr, Δωρόν), meaning "bird" and "gift", respectively. It contains these species: *'' Ornithodoros alactagalis'' Issaakjan, 1936 *†''Ornithodoros antiquus'' Poinar, 1995 *''Ornithodoros apertus'' Walton, 1962 *''Ornithodoros arenicolous'' Hoogstraal, 1953 *''Ornithodoros asperus'' Warburton, 1918 *''Ornithodoros atacamensis'' Muñoz-Leal, Venzal & González-Acuña, 2016 *'' Ornithodoros brasiliensis'' Aragão, 1923 *''Ornithodoros cholodkovskyi'' Pavlovsky, 1930 *''Ornithodoros compactus'' Walton, 1962 *''Ornithodoros coniceps'' Canestrini, 1890 *''Ornithodoros costalis'' Diatta, Bouattour, Durand, Renaud & Trape, 2013 *''Ornithodoros coriaceus'' Koch, 1844 *''Ornith ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jožef Stefan Institute
The Jožef Stefan Institute (IJS, JSI) ( sl, Institut "Jožef Stefan") is the largest research institute in Slovenia. The main research areas are physics, chemistry, molecular biology, biotechnology, information technologies, physics, reactor physics, energy and Natural environment, environment. At the beginning of 2013 the institute had 962 employees, of whom 404 were PhD scientists. The mission of the Jožef Stefan Institute is the accumulation and dissemination of knowledge at the frontiers of natural science and technology for the benefit of society at large through the pursuit of education, learning, research, and development of high technology at the highest international levels of excellence. History The institute was founded by the State Security Administration (Yugoslavia) in 1949 for atomic weapons research. Initially, the Vinča Nuclear Institute in Belgrade was established in 1948, followed by the Ruđer Bošković Institute in Zagreb in 1950 and the Jožef Stefan In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CST9 (gene)
Mont-Tremblant/Lac Ouimet Water Aerodrome was located on Lac Ouimet near Mont-Tremblant, Quebec, Canada. The airport was listed as abandoned in the 15 March 2007 Canada Flight Supplement. See also * Mont-Tremblant/Lac Duhamel Water Aerodrome * Mont-Tremblant/Saint-Jovite Airport Mont-Tremblant/Saint-Jovite Airport is located north of Saint-Jovite, Quebec, Canada. See also * Mont-Tremblant/Lac Duhamel Water Aerodrome * Mont-Tremblant/Lac Ouimet Water Aerodrome Mont-Tremblant/Lac Ouimet Water Aerodrome was located o ... References Defunct seaplane bases in Quebec Airports in Laurentides {{Quebec-airport-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CST8 (gene)
Cystatin-8 is a protein that in humans is encoded by the ''CST8'' gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing identified in mouse is suggested in human based on EST evidence but the full-length nature ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CST7 (gene)
Cystatin-F is a protein that in humans is encoded by the ''CST7'' gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. References ' External links * The MEROPS MEROPS is an online database for peptidases (also known as proteases, proteinases and proteolytic enzym ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CST5
Cystatin-D is a protein that in humans is encoded by the ''CST5'' gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. References External links * The MEROPS MEROPS is an online database for peptidases (also known as proteases, proteinases and proteolyti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CST4
Cystatin-S is a protein that in humans is encoded by the ''CST4'' gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cystatin 3
Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin, or neuroendocrine basic polypeptide), a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition), such as Alzheimer's disease. In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and body fluids. It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Cystatin C belongs to the type 2 cystatin gene family. Role in medicine Ki ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CST2
Cystatin-SA is a protein that in humans is encoded by the ''CST2'' gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. References External links * The MEROPS MEROPS is an online database for peptidases (also known as proteases, proteinases a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CST1
Cystatin-SN is a protein that in humans is encoded by the ''CST1'' gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. References External links * The MEROPS MEROPS is an online database for peptidases (also known as proteases, proteinases and proteolyt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kininogens
Kininogens are precursor proteins for kinins, biologically active polypeptides involved in blood coagulation, vasodilation, smooth muscle contraction, inflammatory regulation, and the regulation of the cardiovascular and renal systems. Types of kininogen There are two main types of kininogen (KNG), high-molecular-weight-kininogen and low-molecular-weight-kininogen, with a third type – T-kininogen – only found in rats but not humans. High molecular weight kininogen High-molecular-weight-kininogen (HK) is a non-enzymatic cofactor involved in the kinin-kallikrein system, which plays a role in blood coagulation, blood pressure regulation, and inflammation. It is synthesized in endothelial cells and is produced mostly by the liver. It is also a precursor protein for bradykinin. Low molecular weight kininogen Low-molecular-weight-kininogen (LK) is mainly a precursor protein for kallidin. LK, however, is not actively involved in blood coagulation, but its byproducts c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
