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Cross-resistance
Cross-resistance is when something develops resistance to several substances that have a similar mechanism of action. For example, if a certain type of bacteria develops resistance to one antibiotic, that bacteria will also have resistance to several other antibiotics that target the same protein or use the same route to get into the bacterium. A real example of cross-resistance occurred for nalidixic acid and ciprofloxacin, which are both quinolone antibiotics. When bacteria developed resistance to ciprofloxacin, they also developed resistance to nalidixic acid because both drugs inhibit topoisomerase, a key enzyme in DNA replication. Due to cross-resistance, antimicrobial treatments like phage therapy can quickly lose their efficacy against bacteria. This makes cross-resistance an important consideration in designing evolutionary therapies. Definition Cross-resistance is the idea is that the development of resistance to one substance subsequently leads to resistance to one or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pesticide Resistance
Pesticide resistance describes the decreased susceptibility of a pest population to a pesticide that was previously effective at controlling the pest. Pest species evolve pesticide resistance via natural selection: the most resistant specimens survive and pass on their acquired heritable changes traits to their offspring.PBS (2001)Pesticide resistance Retrieved on September 15, 2007. If a pest has ''resistance'' then the pesticide lacks ''efficacy'' efficacy and resistance are inversely related. Cases of resistance have been reported in all classes of pests (''i.e.'' crop diseases, weeds, rodents, ''etc.''), with 'crises' in insect control occurring early-on after the introduction of pesticide use in the 20th century. The Insecticide Resistance Action Committee (IRAC) definition of insecticide resistance is ''a heritable change in the sensitivity of a pest population that is reflected in the repeated failure of a product to achieve the expected level of control when used accordi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evolutionary Therapy
Evolutionary therapy is a subfield of evolutionary medicine that utilizes concepts from evolutionary biology in management of diseases caused by evolving entities such as cancer and microbial infections. These evolving disease agents adapt to selective pressure introduced by treatment, allowing them to develop resistance to therapy, making it ineffective. Evolutionary therapy relies on the notion that Darwinian evolution is the main reason behind lethality of late stage cancer and multi-drug resistant bacterial infections such as methicillin-resistant ''Staphylococcus aureus''. Thus, evolutionary therapy suggests that treatment of such highly dynamic evolving diseases should be changing over time to account for changes in disease populations. Adaptive treatment strategies typically cycle between different drugs or drug doses to take advantage of predictable patterns of disease evolution. This is in contrast to standardized treatment approach which is applied to all patients and eq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Biodeterioration & Biodegradation
International is an adjective (also used as a noun) meaning "between nations". International may also refer to: Music Albums * ''International'' (Kevin Michael album), 2011 * ''International'' (New Order album), 2002 * ''International'' (The Three Degrees album), 1975 *''International'', 2018 album by L'Algérino Songs * The Internationale, the left-wing anthem * "International" (Chase & Status song), 2014 * "International", by Adventures in Stereo from ''Monomania'', 2000 * "International", by Brass Construction from ''Renegades'', 1984 * "International", by Thomas Leer from ''The Scale of Ten'', 1985 * "International", by Kevin Michael from ''International'' (Kevin Michael album), 2011 * "International", by McGuinness Flint from ''McGuinness Flint'', 1970 * "International", by Orchestral Manoeuvres in the Dark from '' Dazzle Ships'', 1983 * "International (Serious)", by Estelle from '' All of Me'', 2012 Politics * Political international, any transnational organization of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pesticides
Pesticides are substances that are meant to control pests. This includes herbicide, insecticide, nematicide, molluscicide, piscicide, avicide, rodenticide, bactericide, insect repellent, animal repellent, microbicide, fungicide, and lampricide. The most common of these are herbicides which account for approximately 80% of all pesticide use. Most pesticides are intended to serve as plant protection products (also known as crop protection products), which in general, protect plants from weeds, fungi, or insects. As an example, the fungus ''Alternaria solani'' is used to combat the aquatic weed ''Salvinia''. In general, a pesticide is a chemical (such as carbamate) or biological agent (such as a virus, bacterium, or fungus) that deters, incapacitates, kills, or otherwise discourages pests. Target pests can include insects, plant pathogens, weeds, molluscs, birds, mammals, fish, nematodes (roundworms), and microbes that destroy property, cause nuisance, or spread disease, or ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxicology
Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology. Factors that influence chemical toxicity include the dosage, duration of exposure (whether it is acute or chronic), route of exposure, species, age, sex, and environment. Toxicologists are experts on poisons and poisoning. There is a movement for evidence-based toxicology as part of the larger movement towards evidence-based practices. Toxicology is currently contributing to the field of cancer research, since some toxins can be used as drugs for killing tumor cells. One prime example of this is ribosome-inactivating proteins, tested in the treatment of leukemia. The word ''toxicology'' () is a neocla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Resistance
Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. The term is used in the context of resistance that pathogens or cancers have "acquired", that is, resistance has evolved. Antimicrobial resistance and antineoplastic resistance challenge clinical care and drive research. When an organism is resistant to more than one drug, it is said to be multidrug-resistant. The development of antibiotic resistance in particular stems from the drugs targeting only specific bacterial molecules (almost always proteins). Because the drug is ''so'' specific, any mutation in these molecules will interfere with or negate its destructive effect, resulting in antibiotic resistance. Furthermore, there is mounting concern over the abuse of antibiotics in the farming of livestock, which in the European Union alone accounts for three times the volume dispensed to humans – leading to development of super-resi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disulphide Bond
In biochemistry, a disulfide (or disulphide in British English) refers to a functional group with the structure . The linkage is also called an SS-bond or sometimes a disulfide bridge and is usually derived by the coupling of two thiol groups. In biology, disulfide bridges formed between thiol groups in two cysteine residues are an important component of the secondary and tertiary structure of proteins. ''Persulfide'' usually refers to compounds. In inorganic chemistry disulfide usually refers to the corresponding anion (−S−S−). Organic disulfides Symmetrical disulfides are compounds of the formula . Most disulfides encountered in organo sulfur chemistry are symmetrical disulfides. Unsymmetrical disulfides (also called heterodisulfides) are compounds of the formula . They are less common in organic chemistry, but most disulfides in nature are unsymmetrical. Properties The disulfide bonds are strong, with a typical bond dissociation energy of 60 kcal/mol (251&nbs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Water Association
The International Water Association (IWA) is a nonprofit organization and knowledge hub for the water sector, connecting water professionals and companies to find solutions to the world's water challenges. The IWA is headquartered in London, UK, with a global secretariat based in Nanjing, China, and a regional office in Chennai, India. IWA has a membership comprising technology companies, water and wastewater utilities, and wider stakeholders in the fields of water services, infrastructure engineering and consulting as well as more than 10,000 individuals including scientists and researchers. IWA works across a wide range of issues covering the full water cycle, with four programmes (Digital Water, Basins of the Future, Cities of the Future, Water and Sanitation Services) that work towards achieving the Sustainable Development Goals and addressing the threat to sustainable water supplies posed by climate change. History The IWA has its roots in the ''International Water Supply A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Water Research
''Water Research'' is a peer-reviewed scientific journal covering research on the science and technology of water quality and its management. It was established in 1967 and is published by Elsevier on behalf of the International Water Association. The editor-in-chief is Eberhard Morgenroth (Swiss Federal Institute of Aquatic Science and Technology). Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor of 11.236. See also *List of periodicals published by Elsevier This is a list of scientific, technical and general interest periodicals published by Elsevier or one of its imprints or subsidiary companies. Both printed items and electronic publications are included in this list. A B C D E F G ... References External links *{{Official website, http://www.elsevier.com/wps/find/journaldescription.cws_home/309/description Hydrology journals Elsevier academic journa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Press
Cell Press is an all-science publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies. Many of Cell Press's journals are among the most reputable in their fields. Cell Press was founded and is currently based in Cambridge, MA, and has offices across the United States, Europe, and Asia under its parent company Elsevier. History Benjamin Lewin founded ''Cell'' in January 1974, under the aegis of MIT Press. He then bought the title and established an independent Cell Press in 1986. The company spun off new journals as follows: ''Neuron'' in March 1988; ''Immunity'' in April 1994; and ''Molecular Cell'' in December 1997. Benjamin Lewin left in October 1999, after having sold Cell Press to Elsevier the previous April. Since that time, Cell Press has launched a number of new titles: ''Developmental Cell'' in July 2001; ''Cancer Cell'' in February 2002; ''Cell Metabolism'' in Janua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trends In Microbiology
A fad or trend is any form of collective behavior that develops within a culture, a generation or social group in which a group of people enthusiastically follow an impulse for a short period. Fads are objects or behaviors that achieve short-lived popularity but fade away. Fads are often seen as sudden, quick-spreading, and short-lived. Fads include diets, clothing, hairstyles, toys, and more. Some popular fads throughout history are toys such as yo-yos, hula hoops, and fad dances such as the Macarena, floss and the twist. Similar to habits or customs but less durable, fads often result from an activity or behavior being perceived as emotionally popular or exciting within a peer group, or being deemed "cool" as often promoted by social networks.Kornblum (2007), p. 213. A fad is said to "catch on" when the number of people adopting it begins to increase to the point of being noteworthy. Fads often fade quickly when the perception of novelty is gone. Overview The specific natu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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