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Cross-circulation
Cross-circulation is a medical technique in which the circulatory system of one individual is temporarily connected to and shared with that of another, typically to support or maintain physiological function in cases where one system alone would be insufficient. Initially pioneered in the 1950s by cardiac surgeon C. Walton Lillehei, cross-circulation allowed surgeons to perform open-heart surgery on infants and children before the development of reliable heart-lung machines. More recently, the concept has been adapted to rehabilitate injured donor organs and bioengineer transplantable grafts ex vivo. History Origins in cardiac surgery In the early 1950s, open-heart surgery was limited by the lack of extracorporeal circulation technologies. In 1954, Dr. C. Walton Lillehei at the University of Minnesota introduced cross-circulation as a method to provide oxygenated blood to patients undergoing complex intracardiac repairs. In this procedure, the patient's circulation was t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Minnesota
The University of Minnesota Twin Cities (historically known as University of Minnesota) is a public university, public Land-grant university, land-grant research university in the Minneapolis–Saint Paul, Twin Cities of Minneapolis and Saint Paul, Minnesota, United States. It is the Flagship#Colleges and universities in the United States, flagship institution of the University of Minnesota System and is organized into 19 colleges, schools, and other major academic units. The Twin Cities campus is the oldest and largest in the University of Minnesota system and has the List of United States university campuses by enrollment, ninth-largest (as of the 2022–2023 academic year) main campus student body in the United States, with 54,890 students at the start of the 2023–24 academic year. The campus comprises locations in Minneapolis and Falcon Heights, Minnesota, Falcon Heights, a suburb of St. Paul, approximately apart. The Minnesota Territorial Legislature drafted a charter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) or heart-lung machine, also called the pump or CPB pump, is a machine that temporarily takes over the function of the heart and lungs during open-heart surgery by maintaining the circulation of blood and oxygen throughout the body. As such it is an Extracorporeal, extracorporeal device. CPB is operated by a perfusionist. The machine mechanically circulates and oxygenates blood throughout the patient's body while bypassing the heart and lungs allowing the surgeon to work in a bloodless surgical field. Uses CPB is commonly used in operations or surgical procedures involving the heart. The technique allows the surgical team to oxygenate and circulate the patient's blood, thus allowing the surgeon to operate safely on the heart. In many operations, such as Coronary artery bypass surgery, coronary artery bypass grafting (CABG), the heart is Cardioplegia, arrested, due to the degree of the difficulty of operating on a beating heart. Operations requiring t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Columbia University
Columbia University in the City of New York, commonly referred to as Columbia University, is a Private university, private Ivy League research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church (Manhattan), Trinity Church in Manhattan, it is the oldest institution of higher education in New York (state), New York and the fifth-First university in the United States, oldest in the United States. Columbia was established as a Colonial colleges, colonial college by royal charter under George II of Great Britain. It was renamed Columbia College (New York), Columbia College in 1784 following the American Revolution, and in 1787 was placed under Trustees of Columbia University in the City of New York, a private board of trustees headed by former students Alexander Hamilton and John Jay. In 1896, the campus was moved to its current location in Morningside Heights and renamed Columbia University. Columbia is organized into twenty schoo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vanderbilt University
Vanderbilt University (informally Vandy or VU) is a private university, private research university in Nashville, Tennessee, United States. Founded in 1873, it was named in honor of shipping and railroad magnate Cornelius Vanderbilt, who provided the school its initial $1 million endowment in the hopes that his gift and the greater work of the university would help to heal the sectional wounds inflicted by the American Civil War. Vanderbilt is a founding member of the Southeastern Conference and has been the conference's only private school since 1966. The university comprises ten schools and enrolls nearly 13,800 students from the US and 70 foreign countries. Vanderbilt is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity". Several research centers and institutes are affiliated with the university, including the Robert Penn Warren, Robert Penn Warren Center for the Humanities, the Freedom Foru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gordana Vunjak-Novakovic
Gordana Vunjak-Novakovic ( sr-cyr, Гордана Вуњак Новаковић) FRSC is a Serbian American biomedical engineer and university professor. She is a University Professor at Columbia University, as well as the Mikati Foundation Professor of Biomedical Engineering and Medical Sciences. She also heads the laboratory for Stem Cells and Tissue Engineering at Columbia University. She is part of the faculty at the Irving Comprehensive Cancer Center and the Center for Human Development, both found at Columbia University. She is also an honorary professor at the Faculty of Technology and Metallurgy at the University of Belgrade, an honorary professor at the University of Novi Sad, and an adjunct professor at the Department of Biomedical Engineering at Tufts University. Her focus is on engineering human tissues for regenerative medicine, stem cell research and modeling of disease. Together with her team she has published over 380 scientific papers, 70 book chapters and three ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) or heart-lung machine, also called the pump or CPB pump, is a machine that temporarily takes over the function of the heart and lungs during open-heart surgery by maintaining the circulation of blood and oxygen throughout the body. As such it is an Extracorporeal, extracorporeal device. CPB is operated by a perfusionist. The machine mechanically circulates and oxygenates blood throughout the patient's body while bypassing the heart and lungs allowing the surgeon to work in a bloodless surgical field. Uses CPB is commonly used in operations or surgical procedures involving the heart. The technique allows the surgical team to oxygenate and circulate the patient's blood, thus allowing the surgeon to operate safely on the heart. In many operations, such as Coronary artery bypass surgery, coronary artery bypass grafting (CABG), the heart is Cardioplegia, arrested, due to the degree of the difficulty of operating on a beating heart. Operations requiring t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extracorporeal Membrane Oxygenation
Extracorporeal membrane oxygenation (ECMO) is a form of extracorporeal life support, providing prolonged cardiac and respiratory system, respiratory support to people whose human heart, heart and human lung, lungs are unable to provide an adequate amount of oxygen, gas exchange or blood supply (perfusion) to sustain life. The technology for ECMO is largely derived from cardiopulmonary bypass, which provides shorter-term support with arrested native circulation. The device used is a membrane oxygenator, also known as an artificial lung. ECMO works by temporarily drawing blood from the body to allow artificial oxygenation of the red blood cells and removal of carbon dioxide. Generally, it is used either post-cardiopulmonary bypass or in late-stage treatment of a person with profound heart and/or lung failure, although it is now seeing use as a treatment for cardiac arrest in certain centers, allowing treatment of the underlying cause of arrest while circulation and oxygenation are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Machine Perfusion
Machine perfusion (MP) is an artificial perfusion technique often used for organ preservation to help facilitate organ transplantation. MP works by continuously pumping a specialized solution through Organ donation, donor organs, mimicking the body's natural Hemodynamics, blood flow while actively controlling Thermoregulation, temperature, Oxygen saturation, oxygen levels, Composition of the human body, chemical composition, and mechanical stress within the organ. By maintaining organ viability outside the body for extended periods, machine perfusion addresses critical challenges in organ transplantation, such as limited preservation times. Machine perfusion has various forms and can be categorised according to the temperature of the perfusate: cold (4 °C) and warm (37 °C). Machine perfusion has been applied to kidney transplantation, renal transplantation, liver transplantation and lung transplantation. It is an alternative to static Refrigeration, cold storage (SCS). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organ Transplantation
Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organs may be transported from a donor site to another location. Organs and/or tissues that are transplanted within the same person's body are called autografts. Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either be from a living or cadaveric source. Organs that have been successfully transplanted include the heart, kidneys, liver, lungs, pancreas, intestine, thymus and uterus. Tissues include bones, tendons (both referred to as musculoskeletal grafts), corneae, skin, heart valves, nerves and veins. Worldwide, the kidneys are the most commonly transplanted organs, followed by the liver and then the heart. J. Hartwell Harrison performed the first organ removal for transplant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regenerative Medicine
Regenerative medicine deals with the "process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs. Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and implanting them when the body cannot heal itself. When the cell source for a regenerated organ is derived from the patient's own tissue or cells, the challenge of organ transplant rejection via immunological mismatch is circumvented. This approach could alleviate the problem of the shortage of organs available for donation. Some of the biomedical approaches within the field of regenerative medicine may involve the use of stem cells. Examples include the injection of stem cells or progenitor cells obtained through directed differe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tissue Engineering
Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose, but is not limited to applications involving cells and tissue scaffolds. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance, it can be considered as a field of its own. While most definitions of tissue engineering cover a broad range of applications, in practice, the term is closely associated with applications that repair or replace portions of or whole tissues (i.e. organs, bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
