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Co-incubation
In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm in vitro ("in glass"). The process involves monitoring and stimulating an individual's ovulatory process, removing an ovum or ova (egg or eggs) from their ovaries and letting sperm fertilise them in a culture medium in a laboratory. After the fertilised egg (zygote) undergoes embryo culture for 2–6 days, it is transferred by catheter into the uterus, with the intention of establishing a successful pregnancy. IVF is a type of assisted reproductive technology used for infertility treatment, gestational surrogacy, and, in combination with pre-implantation genetic testing, avoiding transmission of genetic conditions. A fertilised egg from a donor may implant into a surrogate's uterus, and the resulting child is genetically unrelated to the surrogate. Some countries have banned or otherwise regulate the availability of IVF treatment, giving rise to fertility tourism. Restrictio ...
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Embryo Culture
Embryo culture is a component of ''in vitro'' fertilisation where in resultant embryos are allowed to grow for some time in an artificial medium. Duration The duration of embryo culture can be varied, conferring different stages of embryogenesis at embryo transfer. The main stages at which embryo transfer is performed are cleavage stage (day 2 to 4 after co-incubation) or the blastocyst stage (day 5 or 6 after co-incubation). Embryos which reach the day 3 cell stage can be tested for chromosomal or specific genetic defects prior to possible transfer by preimplantation genetic diagnosis (PGD). Embryo culture until the blastocyst stage confers a significant increase in live birth rate per embryo transfer, and there is no evidence of a difference between the groups in cumulative pregnancy rates. Transfer day 2 instead of day 3 after fertilization has no differences in live birth rate. Monozygotic twinning is not increased after blastocyst transfer compared with cleavage-stage embryo ...
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Embryo Transfer
Embryo transfer refers to a step in the process of assisted reproduction in which embryos are placed into the uterus of a female with the intent to establish a pregnancy. This technique (which is often used in connection with in vitro fertilization (IVF), may be used in humans or in animals, in which situations the goals may vary. Embryo transfer can be done at day two or day three, or later in the blastocyst stage, which was first performed in 1984. Factors that can affect the success of embryo transfer include the endometrial receptivity, embryo quality, and embryo transfer technique. Fresh versus frozen Embryos can be either "fresh" from fertilized egg cells of the same menstrual cycle, or "frozen", that is they have been generated in a preceding cycle and undergone embryo cryopreservation, and are thawed just prior to the transfer, which is then termed "frozen embryo transfer" (FET). The outcome from using cryopreserved embryos has uniformly been positive with no increas ...
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Pregnancy
Pregnancy is the time during which one or more offspring develops ( gestates) inside a woman's uterus (womb). A multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occurs by sexual intercourse, but can also occur through assisted reproductive technology procedures. A pregnancy may end in a live birth, a miscarriage, an induced abortion, or a stillbirth. Childbirth typically occurs around 40 weeks from the start of the last menstrual period (LMP), a span known as the gestational age. This is just over nine months. Counting by fertilization age, the length is about 38 weeks. Pregnancy is "the presence of an implanted human embryo or fetus in the uterus"; implantation occurs on average 8–9 days after fertilization. An '' embryo'' is the term for the developing offspring during the first seven weeks following implantation (i.e. ten weeks' gestational age), after which the term ''fetus'' is used until birth. Signs an ...
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Royton
Royton is a town in the Metropolitan Borough of Oldham, Greater Manchester, England, with a population of 21,284 in 2011. Close to the source of the River Irk, near undulating land at the foothills of the South Pennines, it is northwest of Oldham, southeast of Rochdale and northeast of Manchester. Within the boundaries of the Historic counties of England, historic county of Lancashire, Royton and its surroundings have provided evidence of Britons (historic), ancient British, Roman Britain, Roman and Viking activity in the area.. During the Middle Ages, Royton formed a small Township (England), township centred on Royton Hall, a manor house owned by a long succession of dignitaries which included the Baron Byron, Byrons and Radcliffe Baronets, Radcliffes. A settlement expanded outwards from the hall which, by as late as 1780, "contained only a few straggling and mean-built cottages". Farming was the main industry of this rural area, with locals supplementing their incomes by ...
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Robert G
The name Robert is an ancient Germanic given name, from Proto-Germanic "fame" and "bright" (''Hrōþiberhtaz''). Compare Old Dutch ''Robrecht'' and Old High German ''Hrodebert'' (a compound of '' Hruod'' ( non, Hróðr) "fame, glory, honour, praise, renown" and ''berht'' "bright, light, shining"). It is the second most frequently used given name of ancient Germanic origin. It is also in use as a surname. Another commonly used form of the name is Rupert. After becoming widely used in Continental Europe it entered England in its Old French form ''Robert'', where an Old English cognate form (''Hrēodbēorht'', ''Hrodberht'', ''Hrēodbēorð'', ''Hrœdbœrð'', ''Hrœdberð'', ''Hrōðberχtŕ'') had existed before the Norman Conquest. The feminine version is Roberta. The Italian, Portuguese, and Spanish form is Roberto. Robert is also a common name in many Germanic languages, including English, German, Dutch, Norwegian, Swedish, Scots, Danish, and Icelandic. It can be use ...
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Nobel Prize In Physiology Or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace. The Nobel Prize is presented annually on the anniversary of Alfred Nobel's death, 10 December. As of 2022, 114 Nobel Prizes in Physiology or Medicine have been awarded to 226 laureates, 214 men and 12 women. The first one was awarded in 1901 to the German physiologist, Emil von Behring, for his work on serum therapy and the development of a vaccine against diphtheria. The first woman to receive the Nobel Prize in Physiology or Medicine, Gerty Cori, received it in 1947 for her role in elucidati ...
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Patrick Steptoe
Patrick Christopher Steptoe CBE FRS (9 June 1913 – 21 March 1988) was an English obstetrician and gynaecologist and a pioneer of fertility treatment. Steptoe was responsible with biologist and physiologist Robert Edwards and the nurse Jean Purdy for developing in vitro fertilisation. Louise Joy Brown, the first test-tube baby, was born on 25 July 1978. Edwards was awarded the 2010 Nobel Prize in Physiology or Medicine for his work on the development of in vitro fertilisation; Steptoe and Purdy were not eligible for consideration because the Nobel Prize is not awarded posthumously. Education Born in Oxford, Steptoe was educated at The Grammar School, Witney (since 1968 the comprehensive Henry Box School) in Oxfordshire. He went to King's College London and graduated from St George's Hospital Medical School, London in 1939. He served in the Royal Navy from 1939–1946 and attained the rank of Lieutenant Commander. From 1947 to 1949 he was chief assistant in obstetrics and ...
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Jean Purdy
Jean Marian Purdy (25 April 1945 – 16 March 1985) was a British nurse and embryologist and a pioneer of fertility treatment. Purdy was responsible with Robert Edwards and Patrick Steptoe for developing in vitro fertilisation. Louise Joy Brown, the first test-tube baby, was born on 25 July 1978, and Purdy was the first to see the embryonic cells dividing. Edwards was awarded the 2010 Nobel Prize in Physiology or Medicine for his work on the development of in vitro fertilisation; however, because the Nobel Prize is not awarded posthumously, neither Purdy nor Steptoe were eligible for consideration. Purdy was a co-founder of the Bourn Hall Clinic but her role there and in the development of IVF was ignored for 30 years. Education Purdy attended Cambridgeshire High School for Girls between 1956 and 1963 where she became a prefect, joined sports teams and played violin in the orchestra. She trained to be a nurse at Addenbrooke's Hospital in Cambridge. Career After gaining r ...
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FOREIGN
Foreign may refer to: Government * Foreign policy, how a country interacts with other countries * Ministry of Foreign Affairs, in many countries ** Foreign Office, a department of the UK government ** Foreign office and foreign minister * United States state law, a legal matter in another state Science and technology * Foreign accent syndrome, a side effect of severe brain injury * Foreign key, a constraint in a relational database Arts and entertainment * Foreign film or world cinema, films and film industries of non-English-speaking countries * Foreign music or world music * Foreign literature or world literature * '' Foreign Policy'', a magazine Music * "Foreign", a song by Jessica Mauboy from her 2010 album '' Get 'Em Girls'' * "Foreign" (Trey Songz song), 2014 * "Foreign", a song by Lil Pump from the album ''Lil Pump'' Other uses * Foreign corporation, a corporation that can do business outside its jurisdiction * Foreign language, a language not spoken by the peo ...
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Fertility Tourism
Fertility tourism (also referred to as reproductive tourism or cross border reproductive care) is the practice of traveling to another country or jurisdiction for fertility treatment, and may be regarded as a form of medical tourism. One can usually be considered as having fertility issues when they are unable to have a clinical pregnancy after 12 months of attempts with intercourse. Infertility, or the inability to get pregnant, affects about 8-12% of couples looking to conceive or 186 million people globally. In some places, rates of infertility surpass the global average and can go up to 30% depending on the country. Areas with lack of resources, such as assisted reproductive technologies (ARTs), tend to correlate with the highest rates of infertility. The main procedures sought are in vitro fertilization (IVF), artificial insemination by a donor, as well as surrogacy. These methods are types of assisted reproductive technology (ARTs). Each of these three methods have varying p ...
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Robert Geoffrey Edwards
Sir Robert Geoffrey Edwards (27 September 1925 – 10 April 2013) was a British physiologist and pioneer in reproductive medicine, and in-vitro fertilisation (IVF) in particular. Along with obstetrician and gynaecologist Patrick Steptoe and nurse Jean Purdy, Edwards successfully pioneered conception through IVF, which led to the birth of Louise Brown on 1978. They founded the first IVF programme for infertile patients and trained other scientists in their techniques. Edwards was the founding editor-in-chief of ''Human Reproduction'' in 1986. In 2010, he was awarded the Nobel Prize in Physiology or Medicine "for the development of in vitro fertilization". Education and early career Edwards was born in Batley, Yorkshire, and attended Manchester Central High School on Whitworth Street in central Manchester, after which he served in the British Army, and then completed his undergraduate studies in biology, graduating with an Ordinary degree at Bangor University. He studied at ...
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Egg Donation
Egg donation is the process by which a woman donates eggs to enable another woman to conceive as part of an assisted reproduction treatment or for biomedical research. For assisted reproduction purposes, egg donation typically involves in vitro fertilization technology, with the eggs being fertilized in the laboratory; more rarely, unfertilized eggs may be frozen and stored for later use. Egg donation is a third party reproduction as part of assisted reproductive technology. In the United States, the American Society for Reproductive Medicine has issued guidelines for these procedures, and the Food and Drug Administration has a number of guidelines as well. There are boards in countries outside of the US which have the same regulations. However, egg donation agencies in the U.S. can choose whether to abide by the society's regulations or not. History The first child born from egg donation was reported in Australia in 1983. In July 1983, a clinic in Southern California reported a ...
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