|
Barceloneic Acid A
Barceloneic acid A is a farnesyl transferase Farnesyltransferase () is one of the three enzymes in the prenyltransferase group. Farnesyltransferase (FTase) adds a 15-carbon isoprenoid called a farnesol, farnesyl group to proteins bearing a CaaX Sequence motif, motif: a four-amino acid seque ... inhibitor isolate of '' Phoma''. References Transferase inhibitors Natural phenols Salicylic acids Salicylyl ethers Hydroxyquinol ethers Phoma Farnesyltransferase inhibitors Diphenyl ethers {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Farnesyl Transferase
Farnesyltransferase () is one of the three enzymes in the prenyltransferase group. Farnesyltransferase (FTase) adds a 15-carbon isoprenoid called a farnesol, farnesyl group to proteins bearing a CaaX Sequence motif, motif: a four-amino acid sequence at the carboxyl terminus of a protein. Farnesyltransferase's targets include members of the Ras superfamily of GTPase, small GTP-binding proteins critical to cell cycle progression. For this reason, several Farnesyltransferase inhibitor, FTase inhibitors are undergoing testing as anti-cancer agents. FTase inhibitors have shown efficacy as anti-parasitic agents, as well. FTase is also believed to play an important role in development of progeria and various forms of cancers. Farnesyltransferase catalysis, catalyzes the chemical reaction :farnesyl diphosphate + protein-cysteine \rightleftharpoons S-farnesyl protein + diphosphate Thus, the two substrate (biochemistry), substrates of this enzyme are farnesyl diphosphate and protein-cystei ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phoma
''Phoma'' is a genus of common coelomycetous soil fungi. It contains many plant pathogenic species. Description Spores are colorless and unicellular. The pycnidia are black and depressed in the tissues of the host. ''Phoma'' is arbitrarily limited to those species in which the spores are less than 15 µm as the larger spored forms have been placed in the genus ''Macrophoma''. The most important species include ''Phoma beta'' which is the cause of the heart rot and blight of beets, ''Phoma batata'' that produces a dry rot of sweet potato, and ''Phoma solani''. Taxonomy About 140 ''Phoma'' taxa have been defined and recognized which may be divided into two large groups: (i) plurivorous fungi, generally saprobic or weakly parasitic, mainly from temperate regions in Eurasia, but occasionally also found in other parts of the world (including areas with cool or warm climates); and (ii) specific pathogens of cultivated plants. However other estimates place the number of taxa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transferase Inhibitors
A transferase is any one of a class of enzymes that catalyse the transfer of specific functional groups (e.g. a methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor). They are involved in hundreds of different biochemical pathways throughout biology, and are integral to some of life's most important processes. Transferases are involved in myriad reactions in the cell. Three examples of these reactions are the activity of coenzyme A (CoA) transferase, which transfers thiol esters, the action of N-acetyltransferase, which is part of the pathway that metabolizes tryptophan, and the regulation of pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl CoA. Transferases are also utilized during translation. In this case, an amino acid chain is the functional group transferred by a peptidyl transferase. The transfer involves the removal of the growing amino acid chain from the tRNA molecule in the A-site of the ribosome and its su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Phenols
In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of one or more hydroxyl groups (— O H) bonded directly to an aromatic hydrocarbon group. The simplest is phenol, . Phenolic compounds are classified as simple phenols or polyphenols based on the number of phenol units in the molecule. Phenols are both synthesized industrially and produced by plants and microorganisms. Properties Acidity Phenols are more acidic than typical alcohols. The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12). Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book). Condensation with aldehydes and ketones Phenols are susceptible to Electrophilic aromatic substitutions. Condensation with formald ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salicylic Acids
Salicylic acid is an organic compound with the formula HOC6H4CO2H. A colorless, bitter-tasting solid, it is a precursor to and a metabolite of aspirin (acetylsalicylic acid). It is a plant hormone, and has been listed by the EPA Toxic Substances Control Act (TSCA) Chemical Substance Inventory as an experimental teratogen. The name is from Latin ''salix'' for willow tree. It is an ingredient in some anti-acne products. Salts and esters of salicylic acid are known as salicylates. Uses Medicine Salicylic acid as a medication is commonly used to remove the outer layer of the skin. As such, it is used to treat warts, psoriasis, acne vulgaris, ringworm, dandruff, and ichthyosis. Similar to other hydroxy acids, salicylic acid is an ingredient in many skincare products for the treatment of seborrhoeic dermatitis, acne, psoriasis, calluses, corns, keratosis pilaris, acanthosis nigricans, ichthyosis, and warts. Uses in manufacturing Salicylic acid is used as a food preservative ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydroxyquinol Ethers
Hydroxyquinol is an organic compound with the formula C6H3(OH)3. It is one of three isomeric benzenetriols. The compound is a colorless solid that is soluble in water. It reacts with air to give a black insoluble solid. Production It is prepared industrially by acetylation of paraquinone with acetic anhydride followed by hydrolysis of the triacetate. Historically hydroxyquinol was produced by the action of potassium hydroxide on hydroquinone. It can also be prepared by Dehydration reaction, dehydrating fructose. :C6H12O6 → 3 H2O + C6H6O3 Natural occurrence Hydroxyquinol is a common intermediate in the biodegradation of many aromatic compounds. These substrates include monochlorophenols, dichlorophenols, and more complex species such as the pesticide 2,4,5-Trichlorophenoxyacetic acid, 2,4,5-T. Hydroxyquinol commonly occurs in nature as a biodegradation product of catechin, a phenol, natural phenol found in plants (e.g. by soil bacteria ''Bradyrhizobium japonicum''). Hydr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Farnesyltransferase Inhibitors
Farnesyltransferase () is one of the three enzymes in the prenyltransferase group. Farnesyltransferase (FTase) adds a 15-carbon isoprenoid called a farnesyl group to proteins bearing a CaaX motif: a four-amino acid sequence at the carboxyl terminus of a protein. Farnesyltransferase's targets include members of the Ras superfamily of small GTP-binding proteins critical to cell cycle progression. For this reason, several FTase inhibitors are undergoing testing as anti-cancer agents. FTase inhibitors have shown efficacy as anti-parasitic agents, as well. FTase is also believed to play an important role in development of progeria and various forms of cancers. Farnesyltransferase catalyzes the chemical reaction :farnesyl diphosphate + protein-cysteine \rightleftharpoons S-farnesyl protein + diphosphate Thus, the two substrates of this enzyme are farnesyl diphosphate and protein-cysteine, whereas its two products are S-farnesyl protein and diphosphate. Overview Farnesyltransfer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
