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Brucine
Brucine, is an alkaloid closely related to strychnine, most commonly found in the ''Strychnos nux-vomica'' tree. Brucine poisoning is rare, since it is usually ingested with strychnine, and strychnine is more toxic than brucine. In synthetic chemistry, it can be used as a tool for stereospecific chemical syntheses. Brucine is named from the genus '' Brucea'', named after James Bruce who brought back ''Brucea antidysenterica'' from Ethiopia. History Brucine was discovered in 1819 by Pelletier and Caventou in the bark of the ''Strychnos nux-vomica'' tree. While its structure was not deduced until much later, it was determined that it was closely related to strychnine in 1884, when the chemist Hanssen converted both strychnine and brucine into the same molecule. Identification Brucine can be detected and quantified using liquid chromatography-mass spectrometry. Historically, brucine was distinguished from strychnine by its reactivity toward chromic acid. Applications Chemic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strychnine
Strychnine (, , US chiefly ) is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the eyes or mouth, causes poisoning which results in muscular convulsions and eventually death through asphyxia. While it is no longer used medicinally, it was used historically in small doses to strengthen muscle contractions, such as a heart and bowel stimulant and performance-enhancing drug. The most common source is from the seeds of the ''Strychnos nux-vomica'' tree. Biosynthesis Strychnine is a terpene indole alkaloid belonging to the ''Strychnos'' family of '' Corynanthe'' alkaloids, and it is derived from tryptamine and secologanin. The biosynthesis of strychine was solved in 2022. The enzyme, strictosidine synthase, catalyzes the condensation of tryptamine and secologanin, followed by a Pictet-Spengler reaction to form strictosidine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enantioselective Synthesis
Enantioselective synthesis, also called asymmetric synthesis, is a form of chemical synthesis. It is defined by IUPAC as "a chemical reaction (or reaction sequence) in which one or more new elements of chirality are formed in a substrate molecule and which produces the stereoisomeric (enantiomeric or diastereomeric) products in unequal amounts." Put more simply: it is the synthesis of a compound by a method that favors the formation of a specific enantiomer or diastereomer. Enantiomers are stereoisomers that have opposite configurations at every chiral center. Diastereomers are stereoisomers that differ at one or more chiral centers. Enantioselective synthesis is a key process in modern chemistry and is particularly important in the field of pharmaceuticals, as the different enantiomers or diastereomers of a molecule often have different biological activity. Overview Many of the building blocks of biological systems such as sugars and amino acids are produced exclusively as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enantioselective Synthesis
Enantioselective synthesis, also called asymmetric synthesis, is a form of chemical synthesis. It is defined by IUPAC as "a chemical reaction (or reaction sequence) in which one or more new elements of chirality are formed in a substrate molecule and which produces the stereoisomeric (enantiomeric or diastereomeric) products in unequal amounts." Put more simply: it is the synthesis of a compound by a method that favors the formation of a specific enantiomer or diastereomer. Enantiomers are stereoisomers that have opposite configurations at every chiral center. Diastereomers are stereoisomers that differ at one or more chiral centers. Enantioselective synthesis is a key process in modern chemistry and is particularly important in the field of pharmaceuticals, as the different enantiomers or diastereomers of a molecule often have different biological activity. Overview Many of the building blocks of biological systems such as sugars and amino acids are produced exclusively as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strychnine
Strychnine (, , US chiefly ) is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the eyes or mouth, causes poisoning which results in muscular convulsions and eventually death through asphyxia. While it is no longer used medicinally, it was used historically in small doses to strengthen muscle contractions, such as a heart and bowel stimulant and performance-enhancing drug. The most common source is from the seeds of the ''Strychnos nux-vomica'' tree. Biosynthesis Strychnine is a terpene indole alkaloid belonging to the ''Strychnos'' family of '' Corynanthe'' alkaloids, and it is derived from tryptamine and secologanin. The biosynthesis of strychine was solved in 2022. The enzyme, strictosidine synthase, catalyzes the condensation of tryptamine and secologanin, followed by a Pictet-Spengler reaction to form strictosidine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glycine Receptor
The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine. GlyR is an ionotropic receptor that produces its effects through chloride current. It is one of the most widely distributed inhibitory receptors in the central nervous system and has important roles in a variety of physiological processes, especially in mediating inhibitory neurotransmission in the spinal cord and brainstem. The receptor can be activated by a range of simple amino acids including glycine, β-alanine and taurine, and can be selectively blocked by the high-affinity competitive antagonist strychnine. Caffeine is a competitive antagonist of GlyR. Gephyrin has been shown to be necessary for GlyR clustering at inhibitory synapses. GlyR is known to colocalize with the GABAA receptor on some hippocampal neurons. Nevertheless, some exceptions can occur in the central nervous system where the GlyR α1 subunit and gephyrin, its anchoring protein, are not foun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joseph Bienaimé Caventou
Joseph Bienaimé Caventou (30 June 1795 – 5 May 1877) was a French pharmacist. He was a professor at the École de Pharmacie (School of Pharmacy) in Paris. He collaborated with Pierre-Joseph Pelletier in a Parisian laboratory located behind an apothecary. He was a pioneer in the use of mild solvents to isolate a number of active ingredients from plants, making a study of alkaloids from vegetables. Among their successes were the isolation of the following compounds: Quinine sulfate later proved to be an important remedy for the disease malaria. Quinine is the active anti-malarial ingredient in the bark of cinchona tree. Neither of the partners chose to patent their discovery of this compound, releasing it for everybody to use. In 1823 they discovered nitrogen in alkaloid compounds. Other compounds they discovered include colchicine and veratrine. The crater Caventou on the Moon The Moon is Earth's only natural satellite. It is the fifth largest satellite in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Denatured Alcohol
Denatured alcohol (also called methylated spirits in Australia, Canada, Ireland, New Zealand, South Africa, and the United Kingdom; wood spirit; and denatured rectified spirit) is ethanol that has additives to make it poisonous, bad-tasting, foul-smelling, or nauseating to discourage its recreational consumption. It is sometimes dyed so that it can be identified visually. Pyridine and methanol, each and together, make denatured alcohol poisonous; and denatonium makes it bitter. Denatured alcohol is used as a solvent and as fuel for alcohol burners and camping stoves. Because of the diversity of industrial uses for denatured alcohol, hundreds of additives and denaturing methods have been used. The main additive usually is 10% methanol (methyl alcohol), hence the name ''methylated spirits''. Other common additives include isopropyl alcohol, acetone, methyl ethyl ketone, and methyl isobutyl ketone. Denatured alcohol blends average 60 to 90% ethanol. Denaturing alcohol does not ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Count Of Monte Cristo
''The Count of Monte Cristo'' (french: Le Comte de Monte-Cristo) is an adventure novel written by French author Alexandre Dumas (''père'') completed in 1844. It is one of the author's more popular works, along with ''The Three Musketeers''. Like many of his novels, it was expanded from plot outlines suggested by his collaborating ghostwriter Auguste Maquet. The story takes place in France, Italy, and islands in the Mediterranean during the historical events of 1815–1839: the era of the Bourbon Restoration in France, Bourbon Restoration through the reign of Louis-Philippe of France. It begins on the day that Napoleon left his first island of exile, Elba, beginning the Hundred Days period when Napoleon returned to power. The historical setting is a fundamental element of the book, an adventure story centrally concerned with themes of hope, justice, vengeance, mercy, and forgiveness. It centers on a man who is wrongfully imprisoned, escapes from jail, acquires a fortune, and set ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexandre Dumas
Alexandre Dumas (, ; ; born Dumas Davy de la Pailleterie (), 24 July 1802 – 5 December 1870), also known as Alexandre Dumas père (where '' '' is French for 'father', to distinguish him from his son Alexandre Dumas fils), was a French writer. His works have been translated into many languages and he is one of the most widely read French authors. Many of his historical novels of adventure were originally published as serials, including '' The Count of Monte Cristo'', ''The Three Musketeers'', ''Twenty Years After'' and '' The Vicomte of Bragelonne: Ten Years Later''. His novels have been adapted since the early twentieth century into nearly 200 films. Prolific in several genres, Dumas began his career by writing plays, which were successfully produced from the first. He also wrote numerous magazine articles and travel books; his published works totalled 100,000 pages. In the 1840s, Dumas founded the Théâtre Historique in Paris. His father, General Thomas-Alexandre Dumas D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mithridatism
Mithridatism is the practice of protecting oneself against a poison by gradually self-administering non-lethal amounts. The word is derived from Mithridates VI, the King of Pontus, who so feared being poisoned that he regularly ingested small doses, aiming to develop immunity. Background Mithridates VI's father, Mithridates V, was assassinated by poisoning by a conspiracy among his attendants. After this, Mithridates VI's mother held regency over Pontus (a Hellenistic kingdom, 281 BC–62 AD) until a male heir came of age. Mithridates was in competition with his brother for the throne and his mother began to favor his brother. Supposedly, during his youth, he began to suspect plots against him at his own mother's orders and was aware of her possible connection with his father's death. He then began to notice pains in his stomach during his meals and suspected his mother had ordered small amounts of poison to be added to his food to slowly kill him off. With other assassination at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Mechanic (1972 Film)
''The Mechanic'' is a 1972 American action thriller film directed by Michael Winner from a screenplay by Lewis John Carlino. It stars Charles Bronson, in his first collaboration with Winner, Jan-Michael Vincent, Keenan Wynn, and Jill Ireland. The story follows Arthur Bishop (Bronson), a top assassin who takes under his wing Steve McKenna (Vincent), the ruthless and ambitious son of Harry McKenna (Wynn), the former head of the secret organization for which Bishop works. It is noted for its opening, which features no dialogue for the first 16 minutes, as Bronson's character prepares to kill his current target. The title refers to a euphemism for hitmen. Upon its release, the film received generally mixed reviews from critics but it was praised for its action scenes, acting and writing, although Winner's direction and the storytelling was criticized. A remake of the same name was released in 2011, starring Jason Statham as Bishop and Ben Foster as McKenna. The film was a financial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
