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Atromentin
Atromentin is a natural chemical compound found in Agaricomycetes fungi in the orders Agaricales and Thelephorales. It can also be prepared by laboratory synthesis. Chemically, it is a polyphenol and a benzoquinone. Occurrences Atromentin has been found in cultures of ''Clitocybe subilludens'' and in extracts of ''Hydnellum peckii''. The first enzymes in its biosynthesis have been characterized in ''Tapinella panuoides''. One of those is called atromentin synthetase. Biological activities A number of potential biological activities of atromentin have been studied ''in vitro''. Atromentin possesses ''in vitro'' antibacterial activity, inhibiting the enzyme enoyl-acyl carrier protein reductase (essential for the biosynthesis of fatty acids) in the bacteria ''Streptococcus pneumoniae''. Atromentin has been shown to be a smooth muscle stimulant. It also induces apoptosis in isolated human leukemia U937 cells. It is also an anticoagulant. Genetic and enzymatic basis of atrom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atromentin Synthetase
Atromentin is a natural chemical compound found in Agaricomycetes fungi in the orders Agaricales and Thelephorales. It can also be prepared by laboratory synthesis. Chemically, it is a polyphenol and a benzoquinone. Occurrences Atromentin has been found in cultures of ''Clitocybe subilludens'' and in extracts of ''Hydnellum peckii''. The first enzymes in its biosynthesis have been characterized in ''Tapinella panuoides''. One of those is called atromentin synthetase. Biological activities A number of potential biological activities of atromentin have been studied ''in vitro''. Atromentin possesses ''in vitro'' antibacterial activity, inhibiting the enzyme enoyl-acyl carrier protein reductase (essential for the biosynthesis of fatty acids) in the bacteria ''Streptococcus pneumoniae''. Atromentin has been shown to be a smooth muscle stimulant. It also induces apoptosis in isolated human leukemia U937 cells. It is also an anticoagulant. Genetic and enzymatic basis of atrom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydnellum Peckii
''Hydnellum peckii'' is a fungus in the genus '' Hydnellum'' of the family Bankeraceae. It is a hydnoid species, producing spores on the surface of vertical spines or tooth-like projections that hang from the undersurface of the fruit bodies. It is found in North America, Europe, and was recently discovered in Iran (2008) and Korea (2010). ''Hydnellum peckii'' is a mycorrhizal species, and forms mutually beneficial relationships with a variety of coniferous trees, growing on the ground singly, scattered, or in fused masses. The fruit bodies typically have a funnel-shaped cap with a white edge, although the shape can be highly variable. Young, moist fruit bodies can "bleed" bright red guttation droplets that contain a pigment known to have anticoagulant properties similar to heparin. The unusual appearance of the young fruit bodies has earned the species several descriptive common names, including strawberries and cream, the bleeding Hydnellum, the bleeding tooth fungus, the r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atromentic Acid
Atromentic acid is a red-organge pigment found in fungi within the Boletales group. It is the precursor to variegatic acid and xerocomic acid, and is preceded by atromentin. As an example, it is isolated from ''Serpula lacrymans''. It is soluble in methanol. Variants include homoatromentic acid. This pigment has been studied and elucidated by Wolfgang Steglich and colleagues over decades. When atromentin is oxidised with hydrogen peroxide a yellow product is produced. A sodium hydroxide solution is also yellow, but when this is neutralized with acid the red atromentic acid crystallises. Concentrated potassium hydroxide breaks up the compound to p-hydroxyphenylacetic acid and oxalic acid Oxalic acid is an organic acid with the systematic name ethanedioic acid and formula . It is the simplest dicarboxylic acid. It is a white crystalline solid that forms a colorless solution in water. Its name comes from the fact that early inve .... References {{Reflist, refs= Gill, M., and St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anticoagulants
Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms are used in hospitals. Some anticoagulants are used in medical equipment, such as sample tubes, blood transfusion bags, heart–lung machines, and dialysis equipment. One of the first anticoagulants, warfarin, was initially approved as a rodenticide. Anticoagulants are closely related to antiplatelet drugs and thrombolytic drugs by manipulating the various pathways of blood coagulation. Specifically, antiplatelet drugs inhibit platelet aggre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Variegatic Acid
Variegatic acid (3,3',4,4'-tetrahydroxypulvinic acid) is an orange pigment found in some mushrooms. It is responsible for the bluing reaction seen in many bolete mushrooms when they are injured. When mushroom tissue containing variegatic acid is exposed to air, the chemical is enzymatically oxidized to blue quinone methide anions, specifically chinonmethid anions. It is derived from xerocomic acid, which is preceded by atromentic acid and atromentin, and its genetic basis is unknown. In its oxidized form (due to the production of a second lactone ring) is variegatorubin, similar to xerocomorubin. It was first isolated from '' Suillus variegatus''. It has strong antioxidant properties, and a nonspecific inhibitory effect on cytochrome P450 enzymes. A total synthesis was reported in 2001 that uses a Suzuki cross coupling reaction. It was found antibiotically inactive against an array of bacteria and fungi using the disk diffusion assay at 50 μg. However, at similar concentrat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Xerocomic Acid
Xerocomic acid is a red-orange pigment found in fungi of the order ''Boletales'' (and is named after the genus ''Xerocomus''). It is the precursor to variegatic acid, and is preceded by atromentic acid and atromentin. As an example, it is isolated from ''Serpula lacrymans''. It is soluble in methanol. An oxidase acting on xerocomic acid is responsible for the "bluing" reaction seen in mushrooms. Condensation of two units of xerocomic acid form the pigments sclerocitrin, badione A, and also norbadione A, which are found in the mushroom ''Scleroderma citrinum'' Pers. Variants include isoxerocomic acid Isoxerocomic acid is a red-orange pigment found in ''Boletales''. It is the precursor to variegatic acid, and is preceded by atromentic acid and atromentin. As an example, it is isolated from ''Serpula lacrymans''. It is soluble in methanol. It i ... and ''O''-methylxerocomic acid. References {{Reflist, refs= {{cite book, last1=Gill, first1=M., last2=Steglich, first2= W., year=19 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tapinella Panuoides
''Tapinella panuoides'' is a fungus species in the genus '' Tapinella''. Atromentin Atromentin is a natural chemical compound found in Agaricomycetes fungi in the orders Agaricales and Thelephorales. It can also be prepared by laboratory synthesis. Chemically, it is a polyphenol and a benzoquinone. Occurrences Atromentin has ... is a phenolic compound. The first enzymes in its biosynthesis have been characterised in ''T. panuoides''.Characterization of the atromentin biosynthesis genes and enzymes in the homobasidiomycete ''Tapinella panuoides''. Patrick Schneider, Sarah Bouhired and Dirk Hoffmeister, Fungal Genetics and Biology, Volume 45, Issue 11, November 2008, pages 1487-1496, Despite its pleasant taste, the species is poisonous. References External links Boletales Fungi described in 1931 {{Boletales-stub Poisonous fungi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clitocybe Subilludens
] ''Omphalotus subilludens'' is a fungus species in the genus ''Omphalotus''. The type collection was found by Murrill on July 26, 1944, in Gainesville, Florida. It has also been recorded from Texas. Atromentin and thelephoric acid are chemical compounds found in cultures of ''O. subilludens''. Atromentin is an effective anticoagulant, and similar in biological activity to the well-known anticoagulant heparin. Atromentin also possesses antibacterial activity, inhibiting the enzyme enoyl-acyl carrier protein reductase (essential for the biosynthesis of fatty acids) in the bacteria ''Streptococcus pneumoniae ''Streptococcus pneumoniae'', or pneumococcus, is a Gram-positive, spherical bacteria, alpha-hemolytic (under aerobic conditions) or beta-hemolytic (under anaerobic conditions), aerotolerant anaerobic member of the genus Streptococcus. They are ...''. It also produces illudoids.Illudoids from Omphalotus olivascens and Clitocybe subilludens. Nair M. S. R., Carey S. T. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isoxerocomic Acid
Isoxerocomic acid is a red-orange pigment found in ''Boletales''. It is the precursor to variegatic acid, and is preceded by atromentic acid and atromentin. As an example, it is isolated from ''Serpula lacrymans''. It is soluble in methanol. It is the isomer of xerocomic acid and precursor to xerocomorubin Xerocomorubin is a pigment from the fungus order Boletales. It is the oxidized form of isoxerocomic acid. Air oxidation is responsible its formation, and it oxidizes faster to a similar pulvinic acid type pigment oxidized variant, variegatorubin .... References {{Reflist, refs= Gill, M., and Steglich, W. (1987) Pigments of fungi (Macromycetes). Prog Chem Org Nat Prod 51: 1–317. Catechols Furanones 3-Hydroxypropenals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anticoagulant
Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms are used in hospitals. Some anticoagulants are used in medical equipment, such as sample tubes, blood transfusion bags, heart–lung machines, and dialysis equipment. One of the first anticoagulants, warfarin, was initially approved as a rodenticide. Anticoagulants are closely related to antiplatelet drugs and thrombolytic drugs by manipulating the various pathways of blood coagulation. Specifically, antiplatelet drugs inhibit platelet agg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U937 Cells
U-937 cells are a pro-monocytic model cell line used in biomedical research. They were isolated from the histiocytic lymphoma of a 37-year-old male patient in 1974. Due to the relative uniformity of expanded cultures and lower maintance requirements these cells have been since used as an important tool for studying phagocyte differentiation and different kinds of cell-to-cell interactions. U-937 cells mature and differentiate in response to a number of soluble stimuli, adopting the morphology and characteristics of monocytes, macrophages or dendritic cells. U-937 cells are of myeloid lineage and thus secrete a large number of cytokines and chemokines either constitutively (e.g. IL-1 and GM-CSF) or in response to soluble stimuli. TNFα and recombinant GM-CSF for example independently promote IL-10 production in U937 cells. This cell line is therefore widely used for cytokine level read-outs as a result of exposure to various chemical compounds. Namely, production of IL-1β, IL-6, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
