Alternariosis
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Alternariosis
Alternariosis is an infection by ''Alternaria'', presenting cutaneously as focal, ulcerated papules and plaques. Treatment with itraconazole has been reported. See also * Skin lesion A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this s ... References External links Mycosis-related cutaneous conditions {{Cutaneous-infection-stub ...
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Alternaria
''Alternaria'' is a genus of Deuteromycetes fungi. All species are known as major plant pathogens. They are also common allergens in humans, growing indoors and causing hay fever or hypersensitivity reactions that sometimes lead to asthma. They are present in the human mycobiome and readily cause opportunistic infections in immunocompromised people such as AIDS patients. There are 299 species in the genus; they are ubiquitous in the environment and are a natural part of fungal flora almost everywhere. They are normal agents of decay and decomposition. The spores are airborne and found in the soil and water, as well as indoors and on objects. The club-shaped spores are single or form long chains. They can grow thick colonies which are usually green, black, or gray. At least 20% of agricultural spoilage is caused by ''Alternaria'' species, with the most severe losses reaching 80% of yield. Many human health disorders can be caused by these fungi, which grow on skin and mucous me ...
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Lichtheimia Corymbifera
''Lichtheimia corymbifera'' is a thermophilic fungus in the phylum Zygomycota. It normally lives as a saprotrophic mold, but can also be an opportunistic pathogen known to cause pulmonary, CNS, rhinocerebral, or cutaneous infections in animals and humans with impaired immunity. Appearance ''Lichtheimia corymbifera'' was originally described as ''Mucor corymbifer'' in 1884 by Lichtheim from clinical isolations in Wrocław, Poland. At the time of the description, the species epithet, "corymbifer" was attributed to Cohn. In 1903, the fungus was transferred to the mucoralean genus ''Lichtheimia'' (honoring Lichtheim) by Jules Vuillemin as ''L. corymbifera''. In 1912 the species was again transferred by Saccardo and Trotter to the genus ''Absidia'' as ''A. corymbifera'' where it remained for most of the 20th century. Alastruey-Izquierdo and colleagues in 1991 transferred the species to the genus ''Mycocladus'', described originally by Beauverie in 1900. The type of ''Mycocladus'' ha ...
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Papule
A papule is a small, well-defined bump in the skin. It may have a rounded, pointed or flat top, and may have a dip. It can appear with a stalk, be thread-like or look warty. It can be soft or firm and its surface may be rough or smooth. Some have crusts or scales. A papule can be flesh colored, yellow, white, brown, red, blue or purplish. There may be just one or many, and they may occur irregularly in different parts of the body or appear in clusters. It does not contain fluid but may progress to a pustule or vesicle. A papule is smaller than a nodule; it can be as tiny as a pinhead and is typically less than 1 cm in width, according to some sources, and 0.5 cm according to others. When merged together, it appears as a plaque. Its color might indicate its cause, such as white in milia, red in eczema, yellowish in xanthoma and black in melanoma. They may open when scratched and become infected and crusty. Definition A papule is a small, well-defined bump in the s ...
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Itraconazole
Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. It may be given by mouth or intravenously. Common side effects include nausea, diarrhea, abdominal pain, rash, and headache. Severe side effects may include liver problems, heart failure, Stevens–Johnson syndrome and allergic reactions including anaphylaxis. It is unclear if use during pregnancy or breastfeeding is safe. It is in the triazole family of medications. It stops fungal growth by affecting the cell membrane or affecting their metabolism. Itraconazole was patented in 1978 and approved for medical use in the United States in 1992. It is on the World Health Organization's List of Essential Medicines. Recent research works suggest itraconazole (ITZ) could also be used in the treatment of cancer by inhibiting the hedgehog pathway in a similar way to ...
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Skin Lesion
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment. Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses, as well as many nonpathologic states (like, in certain circumstances, melanonychia and racquet nails). While only a small number of skin diseases account for most visits to the physician, thousands of skin conditions have been described. Classification of these conditions often presents many nosological challenges, since underlying causes and pathogenetics are often not known. Therefore, most current textbooks present a classification based on location (for example, conditions of the mucous membrane), morphology ( chronic blistering conditions), cause (skin conditions resul ...
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