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Alpha-gal
Alpha-gal may refer to: * Alpha-galactosidase, an enzyme * Galactose-alpha-1,3-galactose, a carbohydrate also known as Galili antigen * Alpha-gal allergy Alpha-gal allergy — or mammalian meat allergy (MMA) — is a type of meat allergy characterized by a delayed onset of symptoms (3–8 hours) after ingesting mammalian meat and resulting from past exposure to tick bites. It was first reported in ... {{Short pages monitor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-galactosidase
α-Galactosidase ( EC 3.2.1.22, α-GAL, α-GAL A; systematic name α-D-galactoside galactohydrolase) is a glycoside hydrolase enzyme that catalyses the following reaction: : Hydrolysis of terminal, non-reducing α-D-galactose residues in α-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids It catalyzes many catabolic processes, including cleavage of glycoproteins, glycolipids, and polysaccharides. The enzyme is encoded by the ''GLA'' gene. Two recombinant forms of human α-galactosidase are called agalsidase α (INN) and agalsidase β (INN). A mold-derived form is the primary ingredient in gas relief supplements. Function This enzyme is a homodimeric glycoprotein that hydrolyses the terminal α-galactosyl moieties from glycolipids and glycoproteins. It predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. Reaction mechanism Disease relevance Fabry disease ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Galactose-alpha-1,3-galactose
Galactose-''alpha''-1,3-galactose, commonly known as alpha gal and the Galili antigen, is a carbohydrate found in most mammalian cell membranes. It is not found in catarrhines, including humans, who have lost the GGTA1 gene. Their immune systems recognize it as a foreign body and produce xenoreactive immunoglobulin M antibodies, leading to organ rejection after transplantation. Anti-alpha gal immunoglobulin G antibodies are some of the most common in humans. Regular stimulation from gut flora, typically initiated within the first six months of life, leads to an exceptionally high titre of around 1% of all circulating IgG. Alpha gal has also been suggested to play a role in an IgE-specific allergic response to some meats. While this allergic response is quite well documented, there is significant discrepancy between laboratory tests and clinical findings, indicating that much research must still be done on the alpha gal mechanism of action and related tests. Recent studies are sho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
