Alpha-Santalol
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Alpha-Santalol
α-Santalol, also referred to as alpha-santalol, is an organic compound that is classified as a sesquiterpene. It comprises about 55% of the oil of sandalwood, another less abundant component being β-Santalol, β-santalol. As of 2002, about 60 tons of sandalwood oil are produced annually by steam distillation of the heartwood of ''Santalum album''. It is a valued component for perfumes. Because of concerns about the sustainability of sandalwood tree cultivation, scientists have developed routes to α-santalol and β-Santalol, β-santalol via fermentation, including using ''Rhodobacter sphaeroides''. BASF launched its version, Isiobionic Santalol, in July 2020. The oil content varies greatly within the different sandalwood species. This level is typically highest in ''S. album'', ''Santalum, S. paniculatum'' and ''Santalum, S. yasi''. The scent profile also changes considerably between the different species' oils. References

Perfume ingredients Primary alcohols Sesqu ...
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Terpenes
Terpenes () are a class of natural products consisting of compounds with the formula (C5H8)n for n > 1. Comprising more than 30,000 compounds, these unsaturated hydrocarbons are produced predominantly by plants, particularly conifers. Terpenes are further classified by the number of carbons: monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), as examples. The terpene alpha-pinene, is a major component of the common solvent, turpentine. History and terminology The term ''terpene'' was coined in 1866 by the German chemist August Kekulé to denote all hydrocarbons having the empirical formula C10H16, of which camphene was one. Previously, many hydrocarbons having the empirical formula C10H16 had been called "camphene", but many other hydrocarbons of the same composition had had different names. Kekulé coined the term "terpene" in order to reduce the confusion. The name "terpene" is a shortened form of "terpentine", an obsolete spelling of "turpentine". Although sometimes u ...
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β-Santalol
β-Santalol is an organic compound that is classified as a sesquiterpene. It comprises about 20% of the oil of sandalwood, the major component being α-santalol. In 2002, about 60 tons of sandalwood oil were produced by steam distillation of the heartwood of ''Santalum album''.Karl-Georg Fahlbusch, Franz-Josef Hammerschmidt, Johannes Panten, Wilhelm Pickenhagen, Dietmar Schatkowski, Kurt Bauer, Dorothea Garbe, Horst Surburg "Flavors and Fragrances" in ''Ullmann's Encyclopedia of Industrial Chemistry'', Wiley-VCH, Weinheim: 2002. Published online: 15 January 2003; . Because of concerns about the sustainability of sandalwood tree cultivation, scientists have developed routes to α-santalol and β-santalol via fermentation, including using ''Rhodobacter sphaeroides ''Rhodobacter sphaeroides'' is a kind of purple bacterium; a group of bacteria that can obtain energy through photosynthesis. Its best growth conditions are anaerobic phototrophy ( photoheterotrophic and photoautotro ...
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Organic Compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The study of the properties, reactions, and syntheses of organic compounds comprise the discipline known as organic chemistry. For historical reasons, a few classes of carbon-containing compounds (e.g., carbonate salts and cyanide salts), along with a few other exceptions (e.g., carbon dioxide, hydrogen cyanide), are not classified as organic compounds and are considered inorganic. Other than those just named, little consensus exists among chemists on precisely which carbon-containing compounds are excluded, making any rigorous definition of an organic compound elusive. Although organic compounds make up only a small percentage of Earth's crust, they are of central importance because all known life is based on organic compounds. Living t ...
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Sesquiterpene
Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be cyclic or contain rings, including many unique combinations. Biochemical modifications such as oxidation or rearrangement produce the related sesquiterpenoids. Sesquiterpenes are found naturally in plants and insects, as semiochemicals, e.g. defensive agents or pheromones. Biosynthesis and examples The reaction of geranyl pyrophosphate with isopentenyl pyrophosphate results in the 15-carbon farnesyl pyrophosphate (FPP), which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. Cyclic sesquiterpenes are more common than cyclic monoterpenes because of the increased chain length and additional double bond in the sesquiterpene precursors. In addition to common six-membered ring systems such as the ones found in zingiberene and bisacurone, cyclization of one end of the chain to the other end can l ...
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Sandalwood
Sandalwood is a class of woods from trees in the genus ''Santalum''. The woods are heavy, yellow, and fine-grained, and, unlike many other aromatic woods, they retain their fragrance for decades. Sandalwood oil is extracted from the woods for use. Sandalwood is often cited as one of the most expensive woods in the world. Both the wood and the oil produce a distinctive fragrance that has been highly valued for centuries. Consequently, some species of these slow-growing trees have suffered over-harvesting in the past. Nomenclature The nomenclature and the taxonomy of the genus are derived from this species' historical and widespread use. Etymologically it is ultimately derived from Sanskrit चन्दनं ''Chandana'' (''čandana''), meaning "wood for burning incense" and related to ''candrah'', "shining, glowing" and the Latin ''candere'', to shine or glow. It arrived in English via Late Greek, Medieval Latin and Old French in the 14th or 15th century. The sandalwood is indige ...
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Sandalwood Oil
Sandalwood oil is an essential oil obtained from the steam distillation of chips and billets cut from the heartwood of various species of sandalwood trees, mainly ''Santalum album'' (Indian sandalwood) and ''Santalum spicatum'' (Australian sandalwood). Sandalwood oil is used in perfumes, cosmetics, sacred unguents, and as a mild food flavouring. Main constituents Sandalwood oil contains more than 90% sesquiterpenic alcohols of which 50–60% is the tricyclic α-santalol. β-Santalol comprises 20–25%. The composition of the oil will depend on the species, region grown, age of tree, and possibly the season of harvest and details of the extraction process used. Current International Organization for Standardization (ISO) standards for ''S. album'' oil are 41–55% α-santalol and 16–24% β–santalol (ISO 3518: 2002E). Traditional uses Due to its highly coveted fragrance, the essential oil produced from sandalwood is often used in aromatherapy, and is also added to soaps a ...
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Steam Distillation
Steam distillation is a separation process that consists in distilling water together with other volatile and non-volatile components. The steam from the boiling water carries the vapor of the volatiles to a condenser; both are cooled and return to the liquid or solid state, while the non-volatile residues remain behind in the boiling container. If, as is usually the case, the volatiles are not miscible with water, they will spontaneously form a distinct phase after condensation, allowing them to be separated by decantation or with a separatory funnel. Steam distillation can be used when the boiling point of the substance to be extracted is higher than that of water, and the starting material cannot be heated to that temperature because of decomposition or other unwanted reactions. It may also be useful when the amount of the desired substance is small compared to that of the non-volatile residues. It is often used to separate volatile essential oils from plant materi ...
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Santalum Album
''Santalum album'', or Indian sandalwood, is a small tropical tree, and the traditional source of sandalwood oil. It is native to southern India and Southeast Asia. It is considered sacred in some religions like Hinduism, and some cultures place great significance on its fragrant qualities. However, the high value of the species has caused over-exploitation, to the point where the wild population is vulnerable to extinction. Indian sandalwood still commands high prices for its essential oil owing to its high alpha santalol content, but due to lack of sizable trees it is no longer used for fine woodworking as before. The plant is long-lived, but harvest is only viable after many years. Description The height of the evergreen tree is between 4 and 9 metres. They may live to one hundred years of age. The tree is variable in habit, usually upright to sprawling, and may intertwine with other species. The plant parasitises the roots of other tree species, with a haustorium adaptatio ...
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Rhodobacter Sphaeroides
''Rhodobacter sphaeroides'' is a kind of purple bacterium; a group of bacteria that can obtain energy through photosynthesis. Its best growth conditions are anaerobic phototrophy (photoheterotrophic and photoautotrophic) and aerobic chemoheterotrophy in the absence of light. ''R. sphaeroides'' is also able to fix nitrogen.De Universiteit van Texas over ''Rhodobacter sphaeroides''
It is remarkably metabolically diverse, as it is able to grow ically via fermentation and

Santalum
''Santalum'' is a genus of woody flowering plants in the Santalaceae family, the best known and commercially valuable of which is the Indian sandalwood tree, '' S. album''. Members of the genus are trees or shrubs. Most are root parasites which photosynthesize their own food, but tap the roots of other species for water and inorganic nutrients. Several species, most notably ''S. album'', produce highly aromatic wood, used for scents and perfumes and for herbal medicine. About 25 known species range across the Indomalayan, Australasian, and Oceanian realms, from India through Malesia to the Pacific Islands, as far as Hawaii and the Juan Fernández Islands off the coast of South America. Indian sandalwood (''S. album'') is found in the tropical dry deciduous forests of India, the Lesser Sunda Islands of Indonesia, and Arnhem Land of northern Australia. It is the only species of the genus found on the Asian mainland, and may have been introduced to India from the Less ...
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Perfume Ingredients
Perfume (, ; french: parfum) is a mixture of fragrant essential oils or aroma compounds (fragrances), fixatives and solvents, usually in liquid form, used to give the human body, animals, food, objects, and living-spaces an agreeable scent. The 1939 Nobel Laureate for Chemistry, Leopold Ružička stated in 1945 that "right from the earliest days of scientific chemistry up to the present time, perfumes have substantially contributed to the development of organic chemistry as regards methods, systematic classification, and theory." Ancient texts and archaeological excavations show the use of perfumes in some of the earliest human civilizations. Modern perfumery began in the late 19th century with the commercial synthesis of aroma compounds such as vanillin or coumarin, which allowed for the composition of perfumes with smells previously unattainable solely from natural aromatics. History The word ''perfume'' derives from the Latin ''perfumare'', meaning "to smoke through" ...
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Primary Alcohols
A primary alcohol is an alcohol in which the hydroxy group In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula and composed of one oxygen atom covalently bonded to one hydrogen atom. In organic chemistry, alcohols and carboxylic acids contain one or more hydroxy ... is bonded to a primary carbon atom. It can also be defined as a molecule containing a “–CH2OH” group. In contrast, a secondary alcohol has a formula “–CHROH” and a tertiary alcohol has a formula “–CR2OH”, where “R” indicates a carbon-containing group. Examples of primary alcohols include ethanol and n-Butanol, 1-butanol. Methanol is also generally regarded as a primary alcohol, including the 1911 edition of the Encyclopædia Britannica,. See also * Alcohol (chemistry), Alcohol (especially Nomenclature section for discussion on Secondary and Tertiary alcohols.) * Oxidation of primary alcohols to carboxylic acids References

Primary alcohols, ...
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