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Adverse Outcome Pathway
An adverse outcome pathway (AOP) is structured representation of biological events leading to adverse effects and is considered relevant to risk assessment. The AOP links in a linear way existing knowledge along one or more series of causally connected key events (KE) between two points — a molecular initiating event (MIE) and an adverse outcome (AO) that occur at a level of biological organization relevant to risk assessment. The linkage between the events is described by key event relationships (KER) that describe the causal relationships between the key events. AOPs are important for expanding the use of mechanistic toxicological data for risk assessment and regulatory applications with recent applications in further disciplines such as climate science. Background In 2012, the Organisation for Economic Co-operation and Development (OECD) launched a new programme on the development of adverse outcome pathways. A guidance document describes in detail how AOPs are to be d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adverse Effect
An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery. An adverse effect may be termed a "side effect", when judged to be secondary to a main or therapeutic effect. The term complication is similar to adverse effect, but the latter is typically used in pharmacological contexts, or when the negative effect is expected or common. If the negative effect results from an unsuitable or incorrect dosage or procedure, this is called a medical error and not an adverse effect. Adverse effects are sometimes referred to as "iatrogenic" because they are generated by a physician/treatment. Some adverse effects occur only when starting, increasing or discontinuing a treatment. Adverse effects can also be caused by placebo treatments (in which case the adverse effects are referred to as nocebo effects). Using a drug or other medical intervention which is contraindicated may increase the risk of adverse effects. Adverse effects may c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schematic Representation Of AOP With Hypothetical Events
A schematic, or schematic diagram, is a designed representation of the elements of a system using abstract, graphic symbols rather than realistic pictures. A schematic usually omits all details that are not relevant to the key information the schematic is intended to convey, and may include oversimplified elements in order to make this essential meaning easier to grasp, as well as additional organization of the information. For example, a subway map intended for passengers may represent a subway station with a dot. The dot is not intended to resemble the actual station at all but aims to give the viewer information without unnecessary visual clutter. A schematic diagram of a chemical process uses symbols in place of detailed representations of the vessels, piping, valves, pumps, and other equipment that compose the system, thus emphasizing the functions of the individual elements and the interconnections among them and suppresses their physical details. In an electronic circuit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organisation For Economic Co-operation And Development
The Organisation for Economic Co-operation and Development (OECD; french: Organisation de coopération et de développement économiques, ''OCDE'') is an intergovernmental organization, intergovernmental organisation with 38 member countries, founded in 1961 to stimulate economic progress and world trade. It is a Forum (legal), forum whose member countries describe themselves as committed to democracy and the market economy, providing a platform to compare policy experiences, seek answers to common problems, identify good practices, and coordinate domestic and international policies of its members. The majority of OECD members are High income economy, high-income economies with a very high Human Development Index, Human Development Index (HDI), and are regarded as Developed country, developed countries. Their collective population is 1.38 billion. , the OECD member countries collectively comprised 62.2% of List of countries by GDP (nominal), global nominal GDP (US$49.6 trill ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joint Research Centre
The Joint Research Centre (JRC) is the European Commission's science and knowledge service which employs scientists to carry out research in order to provide independent scientific advice and support to European Union (EU) policy. The JRC is a directorate-general of the European Commission under the responsibility of Mariya Gabriel, European Commissioner for Innovation, Research, Culture, Education and Youth. The current director-general of the JRC is Stephen Quest, who took office in 2020, succeeding Vladimír Šucha. Its Board of Governors assists and advises the director-general on matters relating to the role and the scientific, technical and financial management of the JRC. Composed of strategy and coordination, knowledge production, knowledge management and support directorates, the JRC is spread across six sites in five EU countries: in Belgium (Brussels and Geel), Germany (Karlsruhe), Italy (Ispra), the Netherlands (Petten), and Spain (Seville). Their responsibilities ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Commission
The European Commission (EC) is the executive of the European Union (EU). It operates as a cabinet government, with 27 members of the Commission (informally known as "Commissioners") headed by a President. It includes an administrative body of about 32,000 European civil servants. The Commission is divided into departments known as Directorates-General (DGs) that can be likened to departments or ministries each headed by a Director-General who is responsible to a Commissioner. There is one member per member state, but members are bound by their oath of office to represent the general interest of the EU as a whole rather than their home state. The Commission President (currently Ursula von der Leyen) is proposed by the European Council (the 27 heads of state/governments) and elected by the European Parliament. The Council of the European Union then nominates the other members of the Commission in agreement with the nominated President, and the 27 members as a team are then ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Environmental Protection Agency
The Environmental Protection Agency (EPA) is an independent executive agency of the United States federal government tasked with environmental protection matters. President Richard Nixon proposed the establishment of EPA on July 9, 1970; it began operation on December 2, 1970, after Nixon signed an executive order. The order establishing the EPA was ratified by committee hearings in the House and Senate. The agency is led by its administrator, who is appointed by the president and approved by the Senate. The current administrator is Michael S. Regan. The EPA is not a Cabinet department, but the administrator is normally given cabinet rank. The EPA has its headquarters in Washington, D.C., regional offices for each of the agency's ten regions and 27 laboratories. The agency conducts environmental assessment, research, and education. It has the responsibility of maintaining and enforcing national standards under a variety of environmental laws, in consultation with state, tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Engineer Research And Development Center
The Engineer Research and Development Center (ERDC) is a US Army Corps of Engineers (USACE) research and laboratory organization. The headquarters is located in Vicksburg, Mississippi, on the site of an antecedent organization, the Waterways Experiment Station. History In October 1999, the Corps of Engineers established a system of laboratories, called the Engineer Research and Development Center (ERDC). The ERDC was a consolidation of seven, pre-existing laboratories: the ''Coastal and Hydraulics, Environmental, Geotechnical and Structures, and Information Technology Laboratories'' in Vicksburg, Mississippi; the ''Construction Engineering Research Laboratory'' in Champaign, Illinois; the Cold Regions Research and Engineering Laboratory in Hanover, New Hampshire; and the ''Topographic Engineering Center'' in Alexandria, Virginia, which became the Army Geospatial Center (AGC) and started reporting directly to the Corps of Engineers as of 2009. As of 2014, ERDC still maintained a ''G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Army Corps Of Engineers
, colors = , anniversaries = 16 June (Organization Day) , battles = , battles_label = Wars , website = , commander1 = LTG Scott A. Spellmon , commander1_label = Chief of Engineers and Commanding General of the U.S. Army Corps of Engineers , commander2 = MGbr>Richard J. Heitkamp, commander2_label = Deputy Chief of Engineers and Deputy Commanding General , commander3 = MGKimberly M. Colloton, commander3_label = Deputy Commanding General for Military and International Operations , commander4 = MGbr>William H. Graham, commander4_label = Deputy Commanding General for Civil and Emergency Operations , commander5 = COLbr>James J. Handura, commander5_label = Chief of Staff for the U.S. Army Corps of Engi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxicology
Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology. Factors that influence chemical toxicity include the dosage, duration of exposure (whether it is acute or chronic), route of exposure, species, age, sex, and environment. Toxicologists are experts on poisons and poisoning. There is a movement for evidence-based toxicology as part of the larger movement towards evidence-based practices. Toxicology is currently contributing to the field of cancer research, since some toxins can be used as drugs for killing tumor cells. One prime example of this is ribosome-inactivating proteins, tested in the treatment of leukemia. The word ''toxicology'' () is a neocla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Safety
Chemicals as elements, compounds, mixtures, solutions and emulsions are very widely used and transported in the modern industrial society. Of necessity, they are also used in schools, universities and other training facilities to educate pupils in their safe use and handling and also are commonly used in domestic situations for cleaning, gardening and DIY. However, there are chemicals that should not mix or get in contact with others, as they can produce byproducts that may be toxic, carcinogenic, explosive etc, or can be dangerous themselves. To avoid disasters and mishaps, maintaining safety is considered paramount, especially by chemists. Chemical safety includes all those policies, procedures and practices designed to minimise the risk of exposure to potentially hazardous chemicals. This includes the risks of exposure to persons handling the chemicals, to the surrounding environment, and to the communities and ecosystems within that environment. The hazardous nature of many ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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