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Antibody Fragment
An antibody fragment can be: *a fragment antigen-binding The fragment antigen-binding region (Fab region) is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the a ... (Fab) *a fragment crystallizable (Fc) {{Short pages monitor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2fab Fc
Fab or FAB may refer to: Commerce * Fab (brand), a frozen confectionery * Fab (website), an e-commerce design web site * The FAB Awards, a food and beverage award * FAB Link, a European electricity link * Flavoured alcoholic beverage or alcopop, alcoholic drinks with circa 3–7% alcohol * First Abu Dhabi Bank, an Emirati bank * Semiconductor fabrication plant, a factory that manufactures integrated circuits, etc. Culture * ''fab'' (magazine), a Canadian gay magazine * "FAB" (song), a song by JoJo featuring Remy Ma from the 2016 album ''Mad Love'' * Fernsehen aus Berlin, a German television station * Film Advisory Board, an American ratings board * Fullmetal Alchemist Brotherhood, a Japanese anime Health and medicine * Fragment antigen-binding * French–American–British classification systems for hematological disease * Frontal Assessment Battery for the evaluation of executive function Military * Benin Armed Forces (French: ') * Brazilian Air Force (Portuguese: ' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs in a few vari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fragment Antigen-binding
The fragment antigen-binding region (Fab region) is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the antigen-binding site), comprising a set of complementarity-determining regions, at the amino terminal end of the monomer. Each arm of the Y thus binds an epitope on the antigen. Preparation In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. Conversely, the enzyme pepsin cleaves below the hinge region, so the result instead is a F(ab')2 fragment and a pFc' fragment. Recently another enzyme for generation of F(ab')2 has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from ''Streptococcus pyogenes'', trade name FabRICATOR) cleaves IgG in a sequence specific manner at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
