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Y Linkage
Y linkage, also known as holandric inheritance (from Ancient Greek ὅλος ''hólos'', "whole" + ἀνδρός ''andrós'', "male"), describes traits that are produced by genes located on the Y chromosome. It is a form of sex linkage. Y linkage can be difficult to detect. This is partly because the Y chromosome is small and contains fewer genes than the autosomal chromosomes or the X chromosome. It is estimated to contain about 200 genes. Earlier, the human Y chromosome was thought to have little importance;. Although the Y-chromosome is sex-determining in humans and some other species, not all genes that play a role in sex determination are Y-linked. The Y-chromosome, generally does not undergo genetic recombination and only small regions called pseudoautosomal regions exhibit recombination. The majority of the Y-chromosome genes that do not recombine are located in the "non-recombining region". For a trait to be considered Y linkage, it must exhibit these characte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Y-linked
Y linkage, also known as holandric inheritance (from Ancient Greek ὅλος ''hólos'', "whole" + ἀνδρός ''andrós'', "male"), describes traits that are produced by genes located on the Y chromosome. It is a form of sex linkage. Y linkage can be difficult to detect. This is partly because the Y chromosome is small and contains fewer genes than the autosomal chromosomes or the X chromosome. It is estimated to contain about 200 genes. Earlier, the human Y chromosome was thought to have little importance;. Although the Y-chromosome is sex-determining in humans and some other species, not all genes that play a role in sex determination are Y-linked. The Y-chromosome, generally does not undergo genetic recombination and only small regions called pseudoautosomal regions exhibit recombination. The majority of the Y-chromosome genes that do not recombine are located in the "non-recombining region". For a trait to be considered Y linkage, it must exhibit these charact ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Testis-determining Factor
Sex-determining region Y protein (SRY), or Testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the ''SRY'' gene that is responsible for the initiation of male sex determination in therian mammals (placental mammals and marsupials). SRY is an intronless sex-determining gene on the Y chromosome. Mutations in this gene lead to a range of disorders of sex development with varying effects on an individual's phenotype and genotype. TDF is a member of the SOX (SRY-like box) gene family of DNA-binding proteins. When complexed with the SF1 protein, TDF acts as a transcription factor that causes upregulation of other transcription factors, most importantly SOX9. Its expression causes the development of primary sex cords, which later develop into seminiferous tubules. These cords form in the central part of the yet-undifferentiated gonad, turning it into a testis. The now-induced Leydig cells of the testi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Linkage
Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction. Two genetic markers that are physically near to each other are unlikely to be separated onto different chromatids during chromosomal crossover, and are therefore said to be more ''linked'' than markers that are far apart. In other words, the nearer two genes are on a chromosome, the lower the chance of recombination between them, and the more likely they are to be inherited together. Markers on different chromosomes are perfectly ''unlinked'', although the penetrance of potentially deleterious alleles may be influenced by the presence of other alleles, and these other alleles may be located on other chromosomes than that on which a particular potentially deleterious allele is located. Genetic linkage is the most prominent exception to Gregor Mendel's Law of Independent Assortment. The first experiment to demonstrate li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AMELY
Amely was an American rock band from Orlando, Florida, United States, formed in 2008. The band comprised four members; Petie Pizarro (Vocals/Guitar), Brandon Walden (Guitar), Patrick Ridgen (Bass) and Nate Parsell (Drums). The sound of the band was a mix of rock with power pop elements. Having been a band for a short period of time, Amely managed to be signed to an independent record label, for this genre of music, Fearless Records. History Amely did not start out as a fully formed band. It started in 2008 with a studio project for the singer and rhythm guitarist Petie Pizarro (24 years old), who was moving forward as a soloist after the breakup of his previous band. He began writing songs that he would afterwards choose from, for the recording of an EP. Later on, he dubbed "On My Own," at Vision Sound Studios Vision Sound Studios in Jacksonville, Florida with producer Daryl Phennager (Red Jumpsuit Apparatus). Even though Pizarro played most of the instruments on the recordin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
USP9Y
Ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila), also known as USP9Y, is an enzyme which in humans is encoded by the ''USP9Y'' gene. It is required for sperm production. This enzyme is a member of the peptidase C19 family and is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Clinical significance Mutations in this gene have been associated with Sertoli cell-only syndrome Sertoli cell-only syndrome (a.k.a. Del Castillo syndrome and germ cell aplasia ) is a disorder characterized by male sterility without sexual abnormality. It describes a condition of the testes in which only Sertoli cells line is present in seminif ... (SCO) and male infertility. The USP9Y gene is found on the azoospermia factor (AZF) region on the Y chromosome. Men who have impaired or no sperm production often have a deletion in the AZF region, especially in the USP9Y gene, and it was thought tha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UTY (gene)
Histone demethylase UTY is an enzyme that in humans is encoded by the ''UTY'' gene. This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein–protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms. Interactions UTY has been shown to interact with TLE1 Transducin-like enhancer protein 1 is a protein that in humans is encoded by the ''TLE1'' gene. Interactions TLE1 has been shown to interact Advocates for Informed Choice, doing business as, dba interACT or interACT Advocates for Intersex ... and WDR90. References Further reading * * * * * * * * * {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RBM2
RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the ''RBMY1A1'' gene. This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. Alternative splicing Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RBM1
RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the ''RBMY1A1'' gene. This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. Alternative splicing Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DAZ Associated Protein 1
DAZ-associated protein 1 is a protein that in humans is encoded by the ''DAZAP1'' gene. Function In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ1 (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. Interactions DAZ associated protein 1 has been shown to interact with DAZ1 Deleted in azoospermia 1, also known as DAZ1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azoospermia Factor
Azoospermia factor (AZF) is one of several proteins or their genes, which are coded from the AZF region on the human male Y chromosome. Deletions in this region are associated with inability to produce sperm. Subregions within the AZF region are AZFa (sometimes AZF1), AZFb and AZFc (together referred to as AZF2). AZF microdeletions are one of the major causes of male infertility for azoospermia (complete absence of sperm in the ejaculate) and severe oligozoospermia (less than 5 million spermatozoa in the ejaculate) males. ''AZF'' is the term used by the HUGO Gene Nomenclature Committee. Of the 15% of couples who are affected by infertility, 50% of those cases are due to the male partner. 15-30% of male factor infertility cases can be correlated with genetic abnormalities. One of the most commonly identified genetic abnormalities in male factor infertility are microdeletions on the long arm of the Y chromosome (Yq), specifically at a region known as the azoospermic factor (AZF) reg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BPY2
Testis-specific basic protein Y 2 also known as basic charge, Y-linked 2 is a protein that in humans is encoded by the ''BPY2'' gene which resides on the Y chromosome. Function This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palindromic A palindrome is a word, number, phrase, or other sequence of symbols that reads the same backwards as forwards, such as the words ''madam'' or ''racecar'', the date and time ''11/11/11 11:11,'' and the sentence: "A man, a plan, a canal – Pana ... region. References External links * Further reading * * * * * * * {{gene-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AZF2
Azoospermia factor (AZF) is one of several proteins or their genes, which are coded from the AZF region on the human male Y chromosome. Deletions in this region are associated with inability to produce sperm. Subregions within the AZF region are AZFa (sometimes AZF1), AZFb and AZFc (together referred to as AZF2). AZF microdeletions are one of the major causes of male infertility for azoospermia (complete absence of sperm in the ejaculate) and severe oligozoospermia (less than 5 million spermatozoa in the ejaculate) males. ''AZF'' is the term used by the HUGO Gene Nomenclature Committee. Of the 15% of couples who are affected by infertility, 50% of those cases are due to the male partner. 15-30% of male factor infertility cases can be correlated with genetic abnormalities. One of the most commonly identified genetic abnormalities in male factor infertility are microdeletions on the long arm of the Y chromosome (Yq), specifically at a region known as the azoospermic factor (AZF) reg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
