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Worcester Foundation For Experimental Biology
The Worcester Foundation for Biomedical Research (WFBR) was a non-profit biomedical research institute based in Shrewsbury, Massachusetts, United States. History The foundation was established as an independent research center under the name Worcester Foundation for Experimental Biology (WFEB) in 1944 by Hudson Hoagland and Gregory Pincus. It was best known for the development of the combined oral contraceptive pill by Pincus and Min Chueh Chang, an important development in modern birth control, and for pioneering research on in vitro fertilization, ''in vitro'' fertilization by Chang. In the 1970s, WFEB scientists undertook the first systematic study of anti-tumor effects of the anti-estrogen tamoxifen led by 2003 Kettering Prize recipient V. Craig Jordan and initial studies of aromatase inhibitors by 2005 Kettering prize recipient Angela Brodie, two important classes of drugs to treat breast cancer. In the 1950s and 1960s, the WFEB sponsored a Pre-Collegiate Science Summer Program ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non-profit
A nonprofit organization (NPO) or non-profit organisation, also known as a non-business entity, not-for-profit organization, or nonprofit institution, is a legal entity organized and operated for a collective, public or social benefit, in contrast with an entity that operates as a business aiming to generate a profit for its owners. A nonprofit is subject to the non-distribution constraint: any revenues that exceed expenses must be committed to the organization's purpose, not taken by private parties. An array of organizations are nonprofit, including some political organizations, schools, business associations, churches, social clubs, and consumer cooperatives. Nonprofit entities may seek approval from governments to be tax-exempt, and some may also qualify to receive tax-deductible contributions, but an entity may incorporate as a nonprofit entity without securing tax-exempt status. Key aspects of nonprofits are accountability, trustworthiness, honesty, and openness to eve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kettering Prize
The Charles F. Kettering Prize was a US$250,000 award given by the General Motors Cancer Research Foundation for the most outstanding recent contribution to the diagnosis or treatment of cancer. __TOC__ History The award was named in honor of Charles Kettering, Charles F. Kettering, inventor, former General Motors Corporation, General Motors Director, and pioneer of the General Motors Research Laboratories. It was awarded annually from 1979 to 2005. In 2006, due to budget constraints the Alfred P. Sloan Jr. Prize, the Charles F. Kettering prize and the Charles S. Mott Prize, originally each worth $250,000, were consolidated into a single General Motors Cancer Research Award with a combined value of $250,000. The first and only winner of the General Motors Cancer Research Award was Napoleone Ferrara. Since 2006 no more prizes have been awarded. Medalists *2005 Angela H. Brodie *2004 Robert S. Langer *2003 V. Craig Jordan *2002 Brian Druker, Brian J. Druker and Nicholas Lydon, Nic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jon Kabat-Zinn
Jon Kabat-Zinn (born Jon Kabat, June 5, 1944) is an American professor emeritus of medicine and the creator of the Stress Reduction Clinic and the Center for Mindfulness in Medicine, Health Care, and Society at the University of Massachusetts Medical School. Kabat-Zinn was a student of Zen Buddhist teachers such as Philip Kapleau, Thich Nhat Hanh, and Seung Sahn, and a founding member of Cambridge Zen Center. His practice of yoga and studies with Buddhist teachers led him to integrate their teachings with scientific findings. He teaches mindfulness, which he says can help people cope with stress, anxiety, pain, and illness. The stress reduction program created by Kabat-Zinn, mindfulness-based stress reduction (MBSR), is offered by medical centers, hospitals, and health maintenance organizations, and is described in his book ''Full Catastrophe Living''. Life and work Kabat-Zinn was born in New York City in 1944 as the oldest of three children to Elvin Kabat, a biomedical scientist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hoagland-Pincus Conference Center
The Hoagland-Pincus Conference Center is a conference facility of the University of Massachusetts Medical School. It is named for Hudson Hoagland and Gregory Goodwin Pincus, the co-founders of the Worcester Foundation for Experimental Biology. It is located in Shrewsbury, Massachusetts at the site of the former Worcester Foundation for Experimental Biology The Worcester Foundation for Biomedical Research (WFBR) was a non-profit biomedical research institute based in Shrewsbury, Massachusetts, United States. History The foundation was established as an independent research center under the name Worces ..., where the first birth control pill was developed. External links Official site Buildings and structures in Shrewsbury, Massachusetts UMass Chan Medical School {{Massachusetts-struct-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Massachusetts Medical School
The University of Massachusetts Chan Medical School is a public medical school in Worcester, Massachusetts. It is part of the University of Massachusetts system. It is home to three schools: the T.H. Chan School of Medicine, the Morningside Graduate School of Biomedical Sciences, and the Tan Chingfen Graduate School of Nursing, as well as a biomedical research enterprise and a range of public-service initiatives throughout the state. History UMMS was established by the 162nd Massachusetts General Court in 1962 to provide residents of the commonwealth an opportunity to study medicine at an affordable cost and to increase the number of primary-care physicians practicing in the commonwealth's under-served areas. The School of Medicine accepted its first class of 16 students in 1970. Six years later a 371-bed hospital opened on campus; the Graduate School of Biomedical Sciences opened in 1979, and the Graduate School of Nursing opened in 1986. In 1998 the UMMS system of hospitals a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Machine Perfusion
Machine perfusion (MP) is a technique used in organ transplantation as a means of preserving the organs which are to be transplanted. Machine perfusion has various forms and can be categorised according to the temperature of the perfusate: cold (4 °C) and warm (37 °C). Machine perfusion has been applied to renal transplantation, liver transplantation and lung transplantation. It is an alternative to static cold storage (SCS). Research and development A record-long of human transplant organ preservation with machine perfusion of a liver for 3 days rather than usually <12 hours was reported in 2022. It could possibly be extended to 10 days and prevent substantial cell damage by low temperature preservation methods. Alternative approaches include novel solvents. There is a novel organ perfusion system under development that can resto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
17-ketosteroid
150px, Androstenedione 150px, Androsterone 150px, Estrone A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C=O) group. A 17-ketosteroid is a ketosteroid in which the ketone is located specifically at the C17 position (in the upper right corner of most structure diagrams). Examples of 17-ketosteroids include: * Androstenedione * Androstanedione * Androsterone * Dehydroepiandrosterone * Epiandrosterone * Epietiocholanolone * Etiocholanolone 17-Ketosteroids are endogenous steroid hormones. See also * Hydroxysteroid * Hydroxysteroid dehydrogenase Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids. These enzymes also catalyze the reverse reaction, acting as ketosteroid reductases (KSRs). There are four types, cl ... External links * * Ketones Steroids {{steroid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jackson Laboratory
The Jackson Laboratory (often abbreviated as JAX) is an independent, non-profit biomedical research institution which was founded by a eugenicist. It employs more than 3,000 employees in Bar Harbor, Maine; Sacramento, California; Farmington, Connecticut; Shanghai, China; and Yokohama, Japan. The institution is a National Cancer Institute-designated Cancer Center and has NIH Centers of Excellence in aging and systems genetics. The mission of The Jackson Laboratory is "to discover the genetic basis for preventing, treating and curing human diseases, and to enable research and education for the global biomedical community." The laboratory is also the world's source for more than 8,000 strains of genetically defined mice, home of the Mouse Genome Informatics database, and is an international hub for scientific courses, conferences, training and education. Major research areas Jackson Laboratory's research, represented by the activities of more than 60 laboratories, performs resear ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breast Cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin. Risk factors for developing breast cancer include obesity, a lack of physical exercise, alcoholism, hormone replacement therapy during menopause, ionizing radiation, an early age at first menstruation, having children late in life or not at all, older age, having a prior history of breast cancer, and a family history of breast cancer. About 5–10% of cases are the result of a genetic predisposition inherited from a person's parents, including BRCA1 and BRCA2 among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply these ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angela Brodie
Angela Hartley Brodie (28 September 1934 – 7 June 2017) was a British biochemist who pioneered development of steroidal aromatase inhibitors in cancer research. Born in Lancashire (now Greater Manchester), Brodie studied chemical pathology to a doctoral level in Sheffield and was awarded a fellowship sponsored by National Institutes of Health. After 17 years of working in Shrewsbury, Massachusetts on oral contraceptives with Harry Brodie, whom she married, she switched focus to the effects of the oestrogen-producing enzyme, aromatase, on breast cancer. Brodie managed to get an aromatase inhibitor into a limited clinical trial in breast cancer patients in London, which had such a profound effect that it led to Novartis-sponsored trials, the development of formestane, the first aromatase inhibitor, eventually marketed in 1994. Brodie's work has been hailed "as among the most important contributions to cancer cure." Early life and education Brodie was born Angela Hartley on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aromatase Inhibitor
Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and in men, and gynecomastia in men. They may also be used off-label to reduce estrogen conversion when supplementing testosterone exogenously. They may also be used for chemoprevention in women at high risk for breast cancer. Aromatase is the enzyme that catalyzes a key aromatization step in the synthesis of estrogen. It converts the enone ring of androgen precursors such as testosterone, to a phenol, completing the synthesis of estrogen. As such, AIs are estrogen synthesis inhibitors. Because hormone-positive breast and ovarian cancers are dependent on estrogen for growth, AIs are taken to either block the production of estrogen or block the action of estrogen on receptors. Medical uses Cancer In contrast to premenopausal women, in whom most of the estrogen is produced in the ovaries, in postmenopausal women estrogen is mainly produced in peripheral tissues of the bo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tamoxifen
Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and treat breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome. Tamoxifen is typically taken daily by mouth for five years for breast cancer. Serious side effects include a small increased risk of uterine cancer, stroke, vision problems, and pulmonary embolism. Common side effects include irregular periods, weight loss, and hot flashes. It may cause harm to the baby if taken during pregnancy or breastfeeding. It is a selective estrogen-receptor modulator (SERM) and works by decreasing the growth of breast cancer cells. It is a member of the triphenylethylene group of compounds. Tamoxifen was initially made in 1962, by chemist Dora Richardson. It is on the World Health Organization's List of Essential Medicines. Tamoxifen is available as a generic medication. In 202 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
