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Vas-occlusive Contraception
Vas-occlusive contraception is a form of male contraception that blocks sperm transport in the vas deferens, the tubes that carry sperm from the epididymis to the ejaculatory ducts. Various vas-occlusive contraceptive methods have been researched for human-use, with interest in both reversible and irreversible methods, with the purpose of finding a suitable alternative to vasectomy and possible hormonal contraceptive treatments that are currently being researched.Handelsman DJ. Male Contraception. pdated 2015 Dec 18 In: De Groot LJ, Chrousos G, Dungan K, et al., editors. Endotext nternet South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279094/ Potential methods include clips, plugs, valves, polymers, hydrogels, and other devices. Types There are numerous vas-occlusive contraceptive methods and devices that have been researched. Outlined here are a few main categories and descriptions. Intravasal control valve (ICV) An intra ...
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Vasalgel Diagram
Reversible inhibition of sperm under guidance (RISUG), formerly referred to as the synthetic polymer styrene maleic anhydride (SMA), is the development name of a male contraceptive injection developed at IIT Kharagpur in India by the team of Dr. Sujoy K. Guha. RISUG has been patented in India, China, Bangladesh, and the United States. Phase III clinical trials were underway in India, and were slowed by insufficient volunteers. , a contraceptive product based on RISUG, Vasalgel, was under development in the US by Parsemus Foundation, but funding was uncertain. , RSUG and Vasalgel were still in development and testing. Development Sujoy K. Guha developed RISUG after years of developing other inventions. He originally wanted to create an artificial heart that could pump blood using a strong electrical pulse. Using the 13-chamber model of a cockroach heart, he designed a softer pumping mechanism that would theoretically be safe to use in humans. As India's population grew through ...
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Valve
A valve is a device or natural object that regulates, directs or controls the flow of a fluid (gases, liquids, fluidized solids, or slurries) by opening, closing, or partially obstructing various passageways. Valves are technically fittings, but are usually discussed as a separate category. In an open valve, fluid flows in a direction from higher pressure to lower pressure. The word is derived from the Latin ''valva'', the moving part of a door, in turn from ''volvere'', to turn, roll. The simplest, and very ancient, valve is simply a freely hinged flap which swings down to obstruct fluid (gas or liquid) flow in one direction, but is pushed up by the flow itself when the flow is moving in the opposite direction. This is called a check valve, as it prevents or "checks" the flow in one direction. Modern control valves may regulate pressure or flow downstream and operate on sophisticated automation systems. Valves have many uses, including controlling water for irrigation, ...
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Experimental Methods Of Birth Control
An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experimental studies. A child may carry out basic experiments to understand how things fall to the ground, while teams of scientists may take years of systematic investigation to advance their understanding of a phenomenon. Experiments and other types of hands-on activities are very important to student learning in the science classroom. Experiments can raise test scores and help a student become more engaged and interested in the material they are learning, especially when used over time. Experiments can vary from personal and informal natural comparisons (e. ...
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Male Contraceptive
Male contraceptives, also known as male birth control, are methods of preventing pregnancy that solely involve the male physiology. The most common kinds of male contraception include condoms, outercourse, and vasectomy. In domestic animals, castration is commonly used for contraception. Other forms of male contraception are in various stages of research and development. These include methods like RISUG/VasalGel (which has completed a small phase II clinical trial in humans in India) and ultrasound (with results so far obtained in experimental animals). Methods Surgery Vasectomy is a surgical procedure for male sterilization or permanent birth control. During the procedure, the vasa deferentia of a man are severed, and then tied or sealed to prevent sperm from entering into the seminal stream (ejaculate). Vasectomies are usually performed in a physician's office or medical clinic. CDC research has estimated there is a probability of 11 failures per 1,000 procedures over 2 years ...
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Parsemus Foundation
The Parsemus Foundation is an American non-governmental organization whose objective is to advance low-cost evidence-based medicines not pursued by the pharmaceutical industry. The foundation's focus is on supporting small proof-of-concept studies and then pursuing press coverage of the results, so that the advances change treatment practice rather than disappearing into the scientific literature. Many of the studies supported involve low-cost approaches that are not under patent. Background Founded in 2005, Parsemus is an advocate of research into the plausibility of RISUG (and a method based on RISUG, called Vasalgel), a reversible male contraceptive. The foundation began procuring RISUG's United States intellectual property rights in November 2010, completed the acquisition process in February 2012, and is for the past 8 years conducting toxicology tests as an initial step towards Food and Drug Administration approval. Vasgel production has continually been delayed. Human tri ...
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Dimethyl Sulfoxide
Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula ( CH3)2. This colorless liquid is the sulfoxide most widely used commercially. It is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. It has a relatively high boiling point. DMSO has the unusual property that many individuals perceive a garlic-like taste in the mouth after DMSO makes contact with their skin. In terms of chemical structure, the molecule has idealized Cs symmetry. It has a trigonal pyramidal molecular geometry consistent with other three-coordinate S(IV) compounds, with a nonbonded electron pair on the approximately tetrahedral sulfur atom. Synthesis and production Dimethyl sulfoxide was first synthesized in 1866 by the Russian scientist Alexander Zaytsev, who reported his findings in 1867. Dimethyl sulfoxide is produced industrially from dimethyl sulfide, a by-product of the Kraf ...
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Maleic Anhydride
Maleic anhydride is an organic compound with the formula C2H2(CO)2O. It is the acid anhydride of maleic acid. It is a colorless or white solid with an acrid odor. It is produced industrially on a large scale for applications in coatings and polymers. Production Maleic anhydride is produced by vapor-phase oxidation of ''n''-butane. The overall process converts the methyl groups to carboxylate and dehydrogenates the backbone. The selectivity of the process reflects the robustness of maleic anhydride, with its conjugated double-bond system. Traditionally maleic anhydride was produced by the oxidation of benzene or other aromatic compounds. As of 2006, only a few smaller plants continue to use benzene. In both cases, benzene and butane are fed into a stream of hot air, and the mixture is passed through a catalyst bed at high temperature. The ratio of air to hydrocarbon is controlled to prevent the mixture from igniting. Vanadium pentoxide and molybdenum trioxide are the catalysts ...
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Plug
Plug, PLUG, plugs, or plugged may refer to: * Plug (accounting), an unsupported adjustment to an accounting record * Plug (fishing), a family of fishing lures * Plug (horticulture), a planting technique * Plug (jewellery), a type of jewellery worn in stretched piercings * Plug (sanitation), a stopper for a drainage outlet * Butt plug, a sex toy that is inserted into the rectum * Core plug, used to fill the casting holes on engines * Earplug for ear protection * Fusible plug, a safety device in steam boilers * Hair plug, hair that has undergone hair transplantation * Mating plug, secretion used in the mating of some animal species * Plug, a step in the manufacturing process for parts made of carbon-fiber-reinforced polymer * Plug, a type of chewing tobacco made by pressing tobacco with syrup * Plug, the central element of a Plug and feathers, a tool for splitting stone * Plug computer, a type of small-form-factor computer * Portland Linux/Unix Group (PLUG), a group of Linux enthus ...
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Contraception
Birth control, also known as contraception, anticonception, and fertility control, is the use of methods or devices to prevent unwanted pregnancy. Birth control has been used since ancient times, but effective and safe methods of birth control only became available in the 20th century. Planning, making available, and using birth control is called family planning. Some cultures limit or discourage access to birth control because they consider it to be morally, religiously, or politically undesirable. The World Health Organization and United States Centers for Disease Control and Prevention provide guidance on the safety of birth control methods among women with specific medical conditions. The most effective methods of birth control are sterilization by means of vasectomy in males and tubal ligation in females, intrauterine devices (IUDs), and implantable birth control. This is followed by a number of hormone-based methods including oral pills, patches, vaginal rings, a ...
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Clip
Clip or CLIP may refer to: Fasteners * Hair clip, a device used to hold hair together or attaching materials such as caps to the hair * Binder clip, a device used for holding thicker materials (such as large volumes of paper) together ** Bulldog clip, a common binder clip * Paper clip, a device for holding several sheets of paper together * Crocodile clip, or "alligator clip", a temporary electrical connector * Circlip, a semi-flexible metal ring fastener used to hold a pin in place * Roach clip, a holder used for smoking a cannabis cigarette * Bread clip, a device for closing bags * Rail clip, a rail fastener * Money clip, a device for storing cash and credit cards in a very compact fashion Arts and entertainment * Clip art, pre-made images used in graphic arts * Media clip, a short segment of electronic media, either an audio clip or a video clip ** Video clip * ''Clip'' (film), a 2012 film * ''Clips'' (game show), a game show that aired on YTV from 1993 to 1996 Science and ...
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Vasectomy
Vasectomy, or vasoligation, is an elective surgical procedure for male sterilization or permanent contraception. During the procedure, the male vasa deferentia are cut and tied or sealed so as to prevent sperm from entering into the urethra and thereby prevent fertilization of a female through sexual intercourse. Vasectomies are usually performed in a physician's office, medical clinic, or, when performed on an animal, in a veterinary clinic. Hospitalization is not normally required as the procedure is not complicated, the incisions are small, and the necessary equipment routine. The leading potential complication is post-vasectomy pain syndrome. There are several methods by which a surgeon might complete a vasectomy procedure, all of which occlude (i.e., "seal") at least one side of each vas deferens. To help reduce anxiety and increase patient comfort, those who have an aversion to needles may consider a "''no-needle''" application of anesthesia while the ' no-scalpel' or 'op ...
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