Utah-Paradigm Of Bone Physiology
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Utah-Paradigm Of Bone Physiology
The Mechanostat is a term describing the way in which mechanical loading influences bone structure by changing the mass (amount of bone) and architecture (its arrangement) to provide a structure that resists habitual loads with an economical amount of material. As changes in the skeleton are accomplished by the processes of formation ( bone growth) and resorption (bone loss), the mechanostat models the effect of influences on the skeleton by those processes, through their effector cells, osteocytes, osteoblasts, and osteoclasts. The term was invented by Harold Frost: an orthopaedic surgeon and researcher described extensively in articles referring to Frost and Webster Jee's ''Utah Paradigm of Skeletal Physiology''Frost H.M.: ''The Utah Paradigm of Skeletal Physiology Vol. 1'', ISMNI, 1960Frost H.M.: ''The Utah Paradigm of Skeletal Physiology Vol. 2'', ISMNI, 1960 in the 1960s. The Mechanostat is often defined as a practical description of Wolff's law described by Julius Wolff (1836 ...
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Bone Growth
Ossification (also called osteogenesis or bone mineralization) in bone remodeling is the process of laying down new bone material by cells named osteoblasts. It is synonymous with bone tissue formation. There are two processes resulting in the formation of normal, healthy bone tissue: Intramembranous ossification is the direct laying down of bone into the primitive connective tissue (mesenchyme), while endochondral ossification involves cartilage as a precursor. In fracture healing, endochondral osteogenesis is the most commonly occurring process, for example in fractures of long bones treated by plaster of Paris, whereas fractures treated by open reduction and internal fixation with metal plates, screws, pins, rods and nails may heal by intramembranous osteogenesis. Heterotopic ossification is a process resulting in the formation of bone tissue that is often atypical, at an extraskeletal location. Calcification is often confused with ossification. Calcification is synony ...
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Vibration Training
Whole body vibration is a generic term used when vibrations (mechanical oscillations) of any frequency are transferred to the human body. Humans are exposed to vibration through a contact surface that is in a mechanical vibrating state. Humans are generally exposed to many different forms of vibration in their daily lives. This could be a driver's seat, a moving train platform, through a power tool, a training platform, or one of countless other devices. It is a potential form of occupational hazard, particularly after years of exposure. When high frequency vibrations (above 50 Hz) enter through the hands, occupational safety concerns may arise. For example, working with a jackhammer has been known to develop vibration white finger. Exposures and limits have been estimated in the ISO 5349-1 for hand-transmitted vibration. Whole body vibration training as a form of physical exercise can offer some fitness and health benefits, but it is not clear if it is as beneficial as regul ...
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Paraplegia
Paraplegia, or paraparesis, is an impairment in motor or sensory function of the lower extremities. The word comes from Ionic Greek () "half-stricken". It is usually caused by spinal cord injury or a congenital condition that affects the neural (brain) elements of the spinal canal. The area of the spinal canal that is affected in paraplegia is either the thoracic, lumbar, or sacral regions. If four limbs are affected by paralysis, tetraplegia or quadriplegia is the correct term. If only one limb is affected, the correct term is monoplegia. Spastic paraplegia is a form of paraplegia defined by spasticity of the affected muscles, rather than flaccid paralysis. The American Spinal Injury Association classifies spinal cord injury severity in the following manner. ASIA A is the complete loss of sensory function and motor skills below the injury. ASIA B is having some sensory function below the injury, but no motor function. In ASIA C, there is some motor function below the level of ...
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Cosmonauts
An astronaut (from the Ancient Greek (), meaning 'star', and (), meaning 'sailor') is a person trained, equipped, and deployed by a human spaceflight program to serve as a commander or crew member aboard a spacecraft. Although generally reserved for professional space travelers, the term is sometimes applied to anyone who travels into space, including scientists, politicians, journalists, and tourists. "Astronaut" technically applies to all human space travelers regardless of nationality. However, astronauts fielded by Russia or the Soviet Union are typically known instead as cosmonauts (from the Russian "kosmos" (космос), meaning "space", also borrowed from Greek). Comparatively recent developments in crewed spaceflight made by China have led to the rise of the term taikonaut (from the Mandarin "tàikōng" (), meaning "space"), although its use is somewhat informal and its origin is unclear. In China, the People's Liberation Army Astronaut Corps astronauts and their ...
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Astronauts
An astronaut (from the Ancient Greek (), meaning 'star', and (), meaning 'sailor') is a person trained, equipped, and deployed by a human spaceflight program to serve as a commander or crew member aboard a spacecraft. Although generally reserved for professional space travelers, the term is sometimes applied to anyone who travels into space, including scientists, politicians, journalists, and tourists. "Astronaut" technically applies to all human space travelers regardless of nationality. However, astronauts fielded by Russia or the Soviet Union are typically known instead as cosmonauts (from the Russian "kosmos" (космос), meaning "space", also borrowed from Greek). Comparatively recent developments in crewed spaceflight made by China have led to the rise of the term taikonaut (from the Mandarin "tàikōng" (), meaning "space"), although its use is somewhat informal and its origin is unclear. In China, the People's Liberation Army Astronaut Corps astronauts and their ...
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Tibia
The tibia (; ), also known as the shinbone or shankbone, is the larger, stronger, and anterior (frontal) of the two bones in the leg below the knee in vertebrates (the other being the fibula, behind and to the outside of the tibia); it connects the knee with the ankle. The tibia is found on the medial side of the leg next to the fibula and closer to the median plane. The tibia is connected to the fibula by the interosseous membrane of leg, forming a type of fibrous joint called a syndesmosis with very little movement. The tibia is named for the flute ''tibia''. It is the second largest bone in the human body, after the femur. The leg bones are the strongest long bones as they support the rest of the body. Structure In human anatomy, the tibia is the second largest bone next to the femur. As in other vertebrates the tibia is one of two bones in the lower leg, the other being the fibula, and is a component of the knee and ankle joints. The ossification or formation of the bone ...
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Whole Body Vibration
Whole body vibration is a generic term used when vibrations (mechanical oscillations) of any frequency are transferred to the human body. Humans are exposed to vibration through a contact surface that is in a mechanical vibrating state. Humans are generally exposed to many different forms of vibration in their daily lives. This could be a driver's seat, a moving train platform, through a power tool, a training platform, or one of countless other devices. It is a potential form of occupational hazard, particularly after years of exposure. When high frequency vibrations (above 50 Hz) enter through the hands, occupational safety concerns may arise. For example, working with a jackhammer has been known to develop vibration white finger. Exposures and limits have been estimated in the ISO 5349-1 for hand-transmitted vibration. Whole body vibration training as a form of physical exercise can offer some fitness and health benefits, but it is not clear if it is as beneficial as reg ...
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Osteoporosis
Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to bone fragility, and consequent increase in fracture risk. It is the most common reason for a broken bone among the elderly. Bones that commonly break include the vertebrae in the spine, the bones of the forearm, and the hip. Until a broken bone occurs there are typically no symptoms. Bones may weaken to such a degree that a break may occur with minor stress or spontaneously. After the broken bone heals, the person may have chronic pain and a decreased ability to carry out normal activities. Osteoporosis may be due to lower-than-normal maximum bone mass and greater-than-normal bone loss. Bone loss increases after the menopause due to lower levels of estrogen, and after ' andropause' due to lower levels of testosterone. Osteoporosis may also occur due to a number of diseases or treatments, including alcoholism, anorexia, hyperthyroidism, ...
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Harold Frost
Harold M. Frost (1921 – 19 June 2004) was an American orthopedist and surgeon considered to be one of the most important researchers and theorists in the field of bone biology and bone medicine of his time.Turner C, Burr D, Jee WS, Smith S, Recker RR, Axelrod DW, Takahashi HE, Villanueva AR, High WB, Martin RB, Parfitt AM: ''Tribute to Harold M. Frost M.D.'', ''J Musculoskel Neuron Interact'' 2004; 4(4):348-356, Jee WS: ''Harold M. Frost, M.D., D.Sc. (hon) - one man's association'', ''J Musculoskelet Neuronal Interact.'' 2006 Apr-Jun;6(2):113-21, He published nearly 500 peer-reviewed scientific and clinical articles and 16 books. According to the Science Citation Index, he is one of the most cited investigators in skeletal research. Life He received his medical degree from Geisel School of Medicine and Feinberg School of Medicine in 1945. He then did his surgical internship in Worcester, Massachusetts . During this time he was Officer in the Naval Medical Corps from 1946 ...
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Strength Of Materials
The field of strength of materials, also called mechanics of materials, typically refers to various methods of calculating the stresses and strains in structural members, such as beams, columns, and shafts. The methods employed to predict the response of a structure under loading and its susceptibility to various failure modes takes into account the properties of the materials such as its yield strength, ultimate strength, Young's modulus, and Poisson's ratio. In addition, the mechanical element's macroscopic properties (geometric properties) such as its length, width, thickness, boundary constraints and abrupt changes in geometry such as holes are considered. The theory began with the consideration of the behavior of one and two dimensional members of structures, whose states of stress can be approximated as two dimensional, and was then generalized to three dimensions to develop a more complete theory of the elastic and plastic behavior of materials. An important founding pion ...
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