Uricosuria (other)
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Uricosuria (other)
Uricosuria refers to uric acid in the urine. Urine levels of uric acid can be described as: * Hyperuricosuria, an abnormally high level of uric acid in the urine * Hypouricosuria, an abnormally low level of uric acid in the urine Agents that increase uric acid in the urine are termed uricosurics. {{disambiguation ...
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Uric Acid
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. High blood concentrations of uric acid can lead to gout and are associated with other medical conditions, including diabetes and the formation of ammonium acid urate kidney stones. Chemistry Uric acid was first isolated from kidney stones in 1776 by Swedish chemist Carl Wilhelm Scheele. In 1882, the Ukrainian chemist Ivan Horbaczewski first synthesized uric acid by melting urea with glycine. Uric acid displays lactam–lactim tautomerism (also often described as keto–enol tautomerism). Although the lactim form is expected to possess some degree of aromaticity, uric acid crystallizes in the lactam form, with computational chemistry also indicating that tautomer to be the most s ...
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Hyperuricosuria
Hyperuricosuria is a medical term referring to the presence of excessive amounts of uric acid in the urine. For men this is at a rate greater than 800 mg/day, and for women, 750 mg/day. Notable direct causes of hyperuricosuria are dissolution of uric acid crystals in the kidneys or urinary bladder, and hyperuricemia. Notable indirect causes include uricosuric drugs, rapid breakdown of bodily tissues containing large quantities of DNA and RNA, and a diet high in purine. Medications that may contribute to the cure or amelioration of hyperuricosuria include allopurinol which acts by inhibiting xanthine oxidase and reducing uric acid production. Hyperuricosuria ''may'' be a medical sign of: *Gout (very common) *Kidney stones of uric acid (uric acid nephrolithiasis) *Acute uric acid nephropathy *Acute kidney failure *Tumor lysis syndrome *Fanconi syndrome *Dent's disease (very rare) Classification Acute hyperuricosuria is a common complication of tumor lysis syndrome. Thi ...
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