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UCLA's Jonsson Comprehensive Cancer Center
The Jonsson Comprehensive Cancer Center (JCCC) is a cancer research center at University of California, Los Angeles. History The center was originated by UCLA scientists and volunteers who began working together in the late 1960s.Jonsson Comprehensive Cancer Center: University of California at Los Angeles, Los Angeles, California National Cancer Institute (accessed August 22, 2016). The center was formally established in 1974 and was designated as a by the |
UCLA JCCCLogo
The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California State Normal School (now San José State University). This school was absorbed with the official founding of UCLA as the Southern Branch of the University of California in 1919, making it the second-oldest of the 10-campus University of California system (after UC Berkeley). UCLA offers 337 undergraduate and graduate degree programs in a wide range of disciplines, enrolling about 31,600 undergraduate and 14,300 graduate and professional students. UCLA received 174,914 undergraduate applications for Fall 2022, including transfers, making the school the most applied-to university in the United States. The university is organized into the College of Letters and Science and 12 professional schools. Six of the schools offer undergraduate d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alhambra, California
Alhambra (, , ; from " Alhambra") is a city located in the western San Gabriel Valley region of Los Angeles County, California, United States, approximately eight miles from the Downtown Los Angeles Downtown Los Angeles (DTLA) contains the central business district of Los Angeles. In addition, it contains a diverse residential area of some 85,000 people, and covers . A 2013 study found that the district is home to over 500,000 jobs. It is ... civic center. It was incorporated on July 11, 1903. As of the 2020 census, the population was 82,868. The city's ZIP Codes are 91801 and 91803 (plus 91802 for P.O. boxes). History The original inhabitants of the land where Alhambra now sits are the Tongva. The Mission San Gabriel Arcángel, San Gabriel Mission was founded nearby on September 8, 1771, as part of the Spanish conquest and occupation of Alta California. The land that would later become Alhambra was part of a 300,000 acre land grant given to Manuel Nieto (soldier), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Organizations Based In The United States
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of a cell. Ty ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insulin-like Growth Factor 1
Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. IGF-1 is a protein that in humans is encoded by the ''IGF1'' gene. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7,649 Daltons. In dogs, an ancient mutation in IGF1 is the primary cause of the toy phenotype. IGF-1 is produced primarily by the liver. Production is stimulated by growth hormone (GH). Most of IGF-1 is bound to one of 6 binding proteins (IGF-BP). IGFBP-1 is regulated by insulin. IGF-1 is produced throughout life; the highest rates of IGF-1 production occur during the pubertal growth spurt. The lowest levels occur in infancy and old age. A synthetic analog of IGF-1, mecasermin, is used in children for the treatment of growth failure. Cyclic glycine-proline (cGP) is metabolite o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phases Of Clinical Research
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases start with testing for safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective. Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays. Summary Clinical trials testing potential medical products are commonly classified into four phases. The drug development process will normally proceed through all four phases over many years. If the drug successfully passes through Phases I, II, and III, it will usually be approved by the national regulatory authority for use in the general population. Phase IV trials are 'post-marketing' or 'surveillance' studies conducted to monitor safety over sever ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Palbociclib
Palbociclib, sold under the brand name Ibrance among others, is a medication developed by Pfizer for the treatment of HR-positive and HER2-negative breast cancer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Palbociclib was the first CDK4/6 inhibitor to be approved as a cancer therapy. Mechanism of action It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. In the G1 phase of the cell cycle, mammalian cells must pass a checkpoint, known as the restriction point "R", in order to complete the cell cycle and divide. CDK4 and CDK6 complex with cyclin D drive the phosphorylation of the retinoblastoma protein, Rb, which allows the cell to pass R and commit to division. Regulation of one or more proteins involved in this checkpoint is lost in many cancers. However, by inhibiting CDK4/6, palbociclib ensures that the cyclin D-CDK4/6 complex cannot aid in phosphorylating Rb. This prevents the cell from passing R and exiting G1, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ovarian Cancer
Ovarian cancer is a cancerous tumor of an ovary. It may originate from the ovary itself or more commonly from communicating nearby structures such as fallopian tubes or the inner lining of the abdomen. The ovary is made up of three different cell types including epithelial cells, germ cells, and stromal cells. When these cells become abnormal, they have the ability to divide and form tumors. These cells can also invade or spread to other parts of the body. When this process begins, there may be no or only vague symptoms. Symptoms become more noticeable as the cancer progresses. These symptoms may include bloating, vaginal bleeding, pelvic pain, abdominal swelling, constipation, and loss of appetite, among others. Common areas to which the cancer may spread include the lining of the abdomen, lymph nodes, lungs, and liver. The risk of ovarian cancer increases with age. Most cases of ovarian cancer develop after menopause. It is also more common in women who have ovulated m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breast Cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin. Risk factors for developing breast cancer include obesity, a lack of physical exercise, alcoholism, hormone replacement therapy during menopause, ionizing radiation, an early age at first menstruation, having children late in life or not at all, older age, having a prior history of breast cancer, and a family history of breast cancer. About 5–10% of cases are the result of a genetic predisposition inherited from a person's parents, including BRCA1 and BRCA2 among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply these ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Simi Valley, California
Simi Valley (; Chumash: ''Shimiyi'') is a city in the valley of the same name in the southeast region of Ventura County, California, United States. Simi Valley is from Downtown Los Angeles, making it part of the Greater Los Angeles Area. The city sits next to Thousand Oaks, Moorpark, and Chatsworth. As of the 2020 U.S. Census the population was 126,356, up from 124,243 in 2010. The city of Simi Valley is surrounded by the Santa Susana Mountains and the Simi Hills, west of the San Fernando Valley, and northeast of the Conejo Valley. It grew as a commuter bedroom community for the cities in the Los Angeles area, and the San Fernando Valley when a freeway was built over the Santa Susana Pass. The Ronald Reagan Presidential Library, where the former president was buried in 2004, is in Simi Valley. The Reagan Library has hosted Republican primary debates in 2012 and 2016. History Chumash/pre-colonial period Simi Valley was once inhabited by the Chumash people, who also s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Santa Clarita, California
Santa Clarita (; Spanish for "Little St. Clare") is a city in northwestern Los Angeles County in the U.S. state of California. With a 2020 census population of 228,673, it is the third-largest city by population in Los Angeles County, the 17th-largest in California, and the 99th-largest city in the United States. It is located about northwest of downtown Los Angeles, and occupies of land in the Santa Clarita Valley, along the Santa Clara River. It is a notable example of a U.S. edge city, satellite city, or boomburb. Human settlement of the Santa Clarita Valley dates back to the arrival of the Chumash people, who were displaced by the Tataviam circa 450 AD. After Spanish colonists arrived in Alta California, the Rancho San Francisco was established, covering much of the Santa Clarita Valley. Henry Mayo Newhall purchased the Rancho San Francisco in 1875 and established the towns of Saugus and Newhall. The Newhall Land and Farming Company played a major role in the city's de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Porter Ranch, California
Porter Ranch is a suburban neighborhood in the northwest San Fernando Valley region of the City of Los Angeles, California. History New home construction that was completed in the Porter Ranch area in the 1990s–2000s, including the Renaissance Summit development, was mired in controversy and Los Angeles politics in the late 1980s and early 1990s. Existing residents of the Porter Ranch area feared the increased traffic that would be brought by the planned building of an area commercial complex to service the new homes being built. Developments were also criticized for destroying the natural beauty of the brush and wild areas that inhabited the space before the houses were built. However, Shapell Homes, a company founded by Nathan Shapell, a major Los Angeles builder, brought together powerful Los Angeles political figures to support the new home building. Aliso Canyon Bridge In the late 80s, there was an attempt to connect Sesnon Boulevard, the road that flanks the north side ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pasadena, California
Pasadena ( ) is a city in Los Angeles County, California, northeast of downtown Los Angeles. It is the most populous city and the primary cultural center of the San Gabriel Valley. Old Pasadena is the city's original commercial district. Its population was 138,699 at the 2020 census, making it the 44th largest city in California and the ninth-largest city in Los Angeles County. Pasadena was incorporated on June 19, 1886, becoming one of the first cities to be incorporated in what is now Los Angeles County, following the city of Los Angeles (April 4, 1850). Pasadena is known for hosting the annual Rose Bowl football game and Tournament of Roses Parade. It is also home to many scientific, educational, and cultural institutions, including Caltech, Pasadena City College, Kaiser Permanente Bernard J. Tyson School of Medicine, Fuller Theological Seminary, ArtCenter College of Design, the Pasadena Playhouse, the Ambassador Auditorium, the Norton Simon Museum, and the USC Pacif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
