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Tuberous Sclerosis Association
Ann Mercy Hunt MBE (25 October 1938 – 25 June 2014) was a British medical researcher and campaigner. She co-founded the Tuberous Sclerosis Association and became a researcher into the tuberous sclerosis complex. Her youngest son died from the condition aged 13. In 1997 the TSC2 gene was identified by a European consortium supported by her organisation. Life Hunt was born in Welshpool in 1938. Hunt went to City of London School for Girls before taking Chemistry at Cambridge University. She married John Hunt as they both worked in research in America and in the UK, where she learnt about research techniques. John became an academic in Oxford. She had a son who suffered from Tuberous Sclerosis and she was surprised to find that there was so little information or research into the condition. Her youngest son died from the condition aged 13. She founded the Tuberous Sclerosis Association in 1977. Ann got involved with the research required and worked on a database of the behaviour ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Welshpool
Welshpool ( cy, Y Trallwng) is a market town and community in Powys, Wales, historically in the county of Montgomeryshire. The town is from the Wales–England border and low-lying on the River Severn; its Welsh language name ''Y Trallwng'' means "the marshy or sinking land". The community includes Cloddiau and Pool Quay. In English it was initially known as Pool but its name was changed to Welshpool in 1835 to distinguish it from the English town of Poole. The community had a population of 6,664 (as of the 2011 United Kingdom census A census of the population of the United Kingdom is taken every ten years. The 2011 census was held in all countries of the UK on 27 March 2011. It was the first UK census which could be completed online via the Internet. The Office for Nationa ...), with the town having 5,948. It contains much Georgian architecture and is just north of Powis Castle. History St Cynfelin is reputed to be the founder of two churches in the town, St Mary's a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MBE (Order Of The British Empire)
MBE may refer to: Academic qualifications * Master of Bioethics * Master of Bioscience Enterprise * Master of Business Engineering * Master of Business Economics Science and technology * The Mid-Brunhes Event, a climatic change at around 430,000 years ago * Mode-based Execution Control, an x86 virtualization technology * Model-based enterprise, a manufacturing strategy where a 3D model of a product is used to guide its life cycle * Molecular-beam epitaxy, a thin-film crystal growth technique * ''Molecular Biology and Evolution'', a journal * Multi-band excitation, a series of speech coding standards * Multibeam echosounder, a device used to map ocean floors British honours * Member of the Most Excellent Order of the British Empire Other uses * Mail Boxes Etc., a global chain of retail business service centers * Management by exception, a style of business management * Minority business enterprise, a classification of business * ''Morning Becomes Eclectic'', a radio pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tuberous Sclerosis Association
Ann Mercy Hunt MBE (25 October 1938 – 25 June 2014) was a British medical researcher and campaigner. She co-founded the Tuberous Sclerosis Association and became a researcher into the tuberous sclerosis complex. Her youngest son died from the condition aged 13. In 1997 the TSC2 gene was identified by a European consortium supported by her organisation. Life Hunt was born in Welshpool in 1938. Hunt went to City of London School for Girls before taking Chemistry at Cambridge University. She married John Hunt as they both worked in research in America and in the UK, where she learnt about research techniques. John became an academic in Oxford. She had a son who suffered from Tuberous Sclerosis and she was surprised to find that there was so little information or research into the condition. Her youngest son died from the condition aged 13. She founded the Tuberous Sclerosis Association in 1977. Ann got involved with the research required and worked on a database of the behaviour ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tuberous Sclerosis Complex
Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin. A combination of symptoms may include seizures, intellectual disability, developmental delay, behavioral problems, skin abnormalities, lung disease, and kidney disease. TSC is caused by a mutation of either of two genes, ''TSC1'' and ''TSC2'', which code for the proteins hamartin and tuberin, respectively, with ''TSC2'' mutations accounting for the majority and tending to cause more severe symptoms. These proteins act as tumor growth suppressors, agents that regulate cell proliferation and differentiation. Prognosis is highly variable and depends on the symptoms, but life expectancy is normal for many. The prevalence of the disease is estimated to be 7 to 12 in 100,000. The disease is often abbreviated to tuberous sclerosis, which refers to the hard ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TSC2
Tuberous Sclerosis Complex 2 (TSC2), also known as Tuberin, is a protein that in humans is encoded by the ''TSC2'' gene. Function Mutations in this gene lead to tuberous sclerosis. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. Hamartin coded by the gene TSC1 functions as a facilitator of Hsp90 in chaperoning of Tuberin, therefore preventing its ubiquitination and degradation in the proteasome. Alternative splicing results in multiple transcript variants encoding different isoforms of the protein. Mutations in TSC2 can cause Lymphangioleiomyomatosis, a disease caused by the enlargement of tissue in the lungs, creating cysts and tumours and causing difficulty breathing. Because Tuberin regulates cell size, along with the protein Hamartin, mutations to TSC1 and TSC2 genes may prevent the control of cell growth in the lungs of individuals. Cell Pathology Cells from individuals with pathogenic mutations in the TSC2 gene display d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
City Of London School For Girls
(''O Lord Direct us'') , established = 1894 , closed = , type = Independent day school , religion = , president = , head_label = Headmistress , head = Jenny Brown , r_head_label = , r_head = , founder = William Ward , specialist = , county = BarbicanLondon, EC2 , country = United Kingdom , local_authority = City of London , dfeno = 201/6005 , urn = 100001 , ofsted = , staff = , enrolment = 707 , gender = Girls , lower_age = 7 , upper_age = 18 , houses = Fleet, Tudor, St. Bride & Ward , colours = Red , publication = , free_label_1 = Former pupils , free_1 = City of London Old Girls' Association , website = http://www.clsg.org.uk The City of London School for Girls (CLSG) is an independent school in the Barbican in the City of London. It is th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1938 Births
Events January * January 1 ** The Constitution of Estonia#Third Constitution (de facto 1938–1940, de jure 1938–1992), new constitution of Estonia enters into force, which many consider to be the ending of the Era of Silence and the authoritarian regime. ** state-owned enterprise, State-owned railway networks are created by merger, in France (SNCF) and the Netherlands (Nederlandse Spoorwegen – NS). * January 20 – King Farouk of Egypt marries Safinaz Zulficar, who becomes Farida of Egypt, Queen Farida, in Cairo. * January 27 – The Honeymoon Bridge (Niagara Falls), Honeymoon Bridge at Niagara Falls, New York, collapses as a result of an ice jam. February * February 4 ** Adolf Hitler abolishes the War Ministry and creates the Oberkommando der Wehrmacht (High Command of the Armed Forces), giving him direct control of the German military. In addition, he dismisses political and military leaders considered unsympathetic to his philosophy or policies. Gene ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2014 Deaths
This is a list of deaths of notable people, organised by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked here. 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 See also * Lists of deaths by day The following pages, corresponding to the Gregorian calendar, list the historical events, births, deaths, and holidays and observances of the specified day of the year: Footnotes See also * Leap year * List of calendars * List of non-standard ... * Deaths by year {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
People From Welshpool
A person ( : people) is a being that has certain capacities or attributes such as reason, morality, consciousness or self-consciousness, and being a part of a culturally established form of social relations such as kinship, ownership of property, or legal responsibility. The defining features of personhood and, consequently, what makes a person count as a person, differ widely among cultures and contexts. In addition to the question of personhood, of what makes a being count as a person to begin with, there are further questions about personal identity and self: both about what makes any particular person that particular person instead of another, and about what makes a person at one time the same person as they were or will be at another time despite any intervening changes. The plural form "people" is often used to refer to an entire nation or ethnic group (as in "a people"), and this was the original meaning of the word; it subsequently acquired its use as a plural form of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Researchers
Medical research (or biomedical research), also known as experimental medicine, encompasses a wide array of research, extending from "basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scientific principles that may apply to a ''preclinical'' understanding – to clinical research, which involves studies of people who may be subjects in clinical trials. Within this spectrum is applied research, or translational research, conducted to expand knowledge in the field of medicine. Both clinical and preclinical research phases exist in the pharmaceutical industry's drug development pipelines, where the clinical phase is denoted by the term ''clinical trial''. However, only part of the clinical or preclinical research is oriented towards a specific pharmaceutical purpose. The need for fundamental and mechanism-based understanding, diagnostics, medical devices, and non-pharmaceutical therapies means that pharmaceutical research is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Women Chemists
A woman is an adult female human. Prior to adulthood, a female human is referred to as a girl (a female child or adolescent). The plural ''women'' is sometimes used in certain phrases such as "women's rights" to denote female humans regardless of age. Typically, women inherit a pair of X chromosomes, one from each parent, and are capable of pregnancy and giving birth from puberty until menopause. More generally, sex differentiation of the female fetus is governed by the lack of a present, or functioning, SRY-gene on either one of the respective sex chromosomes. Female anatomy is distinguished from male anatomy by the female reproductive system, which includes the ovaries, fallopian tubes, uterus, vagina, and vulva. A fully developed woman generally has a wider pelvis, broader hips, and larger breasts than an adult man. Women have significantly less facial and other body hair, have a higher body fat composition, and are on average shorter and less muscular than men. Thro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Welsh Chemists
Welsh may refer to: Related to Wales * Welsh, referring or related to Wales * Welsh language, a Brittonic Celtic language spoken in Wales * Welsh people People * Welsh (surname) * Sometimes used as a synonym for the ancient Britons (Celtic people) Animals * Welsh (pig) Places * Welsh Basin, a basin during the Cambrian, Ordovician and Silurian geological periods * Welsh, Louisiana, a town in the United States * Welsh, Ohio, an unincorporated community in the United States See also * Welch (other) * * * Cambrian + Cymru Wales ( cy, Cymru ) is a country that is part of the United Kingdom. It is bordered by England to the east, the Irish Sea to the north and west, the Celtic Sea to the south west and the Bristol Channel to the south. It had a population in 202 ... {{Disambiguation Language and nationality disambiguation pages ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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