Tropomodulin
Tropomodulin (TMOD) is a protein which binds and caps the minus end of actin (the "pointed" end), regulating the length of actin filaments in muscle and non-muscle cells. The protein functions by physically blocking the spontaneous dissociation of ADP-bound actin monomers from the minus end of the actin fibre. This, along with plus end capping proteins, such as capZ CapZ, also known as CAPZ, CAZ1 and CAPPA1, is a capping protein that caps the barbed end of actin filaments in muscle cells. Structure CapZ is a heterodimeric molecule, made up of an α and β subunit. The α and β subunits are similar in struct ... stabilise the structure of the actin filament. End capping is particularly important when long-lived actin filaments are necessary, for example: in myofibrils. Inhibition of tropomodulin capping activity leads to dramatic increase in thin filament length from its pointed end. Genes *'' TMOD1'' *'' TMOD2'' *'' TMOD3'' *'' TMOD4'' References External links * ...
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TMOD4
Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the ''TMOD4'' gene. Function This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. References Further reading

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